ZNHI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNHI1_HUMAN
• UniProt AC: O43257
• Protein Name: Zinc finger HIT domain-containing protein 1
• Gene Name: ZNHIT1
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Subcellular Localization: Nucleus .
• Protein Description: Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity..
• Protein Sequence: MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	AGLPQLGKRLPQFDD CCHHHHHHHCCCCCC	60.39	22817900
53	Acetylation	AGLPQLGKRLPQFDD CCHHHHHHHCCCCCC	60.39	25953088
66	Acetylation	DDDADTGKKKKKTRG CCCCCCCCCCCCCCC	64.61	23954790
66	Ubiquitination	DDDADTGKKKKKTRG CCCCCCCCCCCCCCC	64.61	29967540
67	Ubiquitination	DDADTGKKKKKTRGD CCCCCCCCCCCCCCC	71.78	24816145
67	Acetylation	DDADTGKKKKKTRGD CCCCCCCCCCCCCCC	71.78	25953088
68	Ubiquitination	DADTGKKKKKTRGDH CCCCCCCCCCCCCCH	64.09	22817900
82	Ubiquitination	HFKLRFRKNFQALLE HHHHHHHHHHHHHHH	60.44	24816145
103	Phosphorylation	AEGPNYLTACAGPPS HCCCCCEEECCCCCC	14.88	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
103	T	Phosphorylation	Kinase	MAPK11	Q15759	Uniprot
103	T	Phosphorylation	Kinase	P38A	Q16539	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNHI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNHI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2AZ_HUMAN	H2AFZ	physical	20473270
ARP6_HUMAN	ACTR6	physical	20473270
KR107_HUMAN	KRTAP10-7	physical	25416956
ACL6A_HUMAN	ACTL6A	physical	28561026
ARP6_HUMAN	ACTR6	physical	28561026
DMAP1_HUMAN	DMAP1	physical	28561026
RUVB1_HUMAN	RUVBL1	physical	28561026
RUVB2_HUMAN	RUVBL2	physical	28561026
SRCAP_HUMAN	SRCAP	physical	28561026
VPS72_HUMAN	VPS72	physical	28561026
YETS4_HUMAN	YEATS4	physical	28561026
ZNHI1_HUMAN	ZNHIT1	physical	28561026

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A new p38 MAP kinase-regulated transcriptional coactivator thatstimulates p53-dependent apoptosis.";
Cuadrado A., Lafarga V., Cheung P.C., Dolado I., Llanos S., Cohen P.,Nebreda A.R.;
EMBO J. 26:2115-2126(2007).
Cited for: INTERACTION WITH MAPK11 AND MAPK14, PHOSPHORYLATION AT THR-103 BYMAPK11 AND MAPK14, INDUCTION BY DNA DAMAGE, FUNCTION, AND MUTAGENESISOF THR-103.
PubMed: 17380123