dbPTM

SRCAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRCAP_HUMAN
UniProt AC	Q6ZRS2
Protein Name	Helicase SRCAP
Gene Name	SRCAP
Organism	Homo sapiens (Human).
Sequence Length	3230
Subcellular Localization	Nucleus .
Protein Description	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription..
Protein Sequence	MQSSPSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGPPGPPDGATVPLEGFSLSQAADLANKGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETIEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSDTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQADEEEEDDDFGVEYLLARDEEQSEADAGSGPPTPGPTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSSSVPSAPEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEAEASGEEEEGDGTPRRRPGPRRLVGTTNQGDQRILRSSAPPSLAGPAVSHRGRKAKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Acetylation	AEIAEQAKHEAEIET HHHHHHHHHHHHHHH	41.49	26051181
120	Phosphorylation	LRKEGFWSLKRLPKV HHHCCCCCCCCCCCC	23.04	21815630
196	O-linked_Glycosylation	AKLRRIASTMAKDVR HHHHHHHHHHHHHHH	19.15	30379171
216	Ubiquitination	VEKVVQFKQQSRLEE HHHHHHHHHHHHHHH	30.27	29967540
243	Phosphorylation	IVGQTEKYSDLLSQS HHCCHHHHHHHHHHH	10.94	29396449
244	Phosphorylation	VGQTEKYSDLLSQSL HCCHHHHHHHHHHHC	32.61	29396449
248	Phosphorylation	EKYSDLLSQSLNQPL HHHHHHHHHHCCCCC	25.64	17525332
250	Phosphorylation	YSDLLSQSLNQPLTS HHHHHHHHCCCCCCC	26.38	25159151
256	Phosphorylation	QSLNQPLTSSKAGSS HHCCCCCCCCCCCCC	37.32	25159151
257	Phosphorylation	SLNQPLTSSKAGSSP HCCCCCCCCCCCCCC	37.21	25159151
258	Phosphorylation	LNQPLTSSKAGSSPC CCCCCCCCCCCCCCC	22.68	25159151
262	Phosphorylation	LTSSKAGSSPCLGSS CCCCCCCCCCCCCCC	35.65	21712546
263	Phosphorylation	TSSKAGSSPCLGSSS CCCCCCCCCCCCCCC	20.79	21712546
268	Phosphorylation	GSSPCLGSSSAASSP CCCCCCCCCCCCCCC	14.26	23663014
269	Phosphorylation	SSPCLGSSSAASSPP CCCCCCCCCCCCCCC	23.38	23663014
270	Phosphorylation	SPCLGSSSAASSPPP CCCCCCCCCCCCCCC	29.56	30278072
273	Phosphorylation	LGSSSAASSPPPPAS CCCCCCCCCCCCCHH	42.99	30266825
274	Phosphorylation	GSSSAASSPPPPASR CCCCCCCCCCCCHHH	36.38	30266825
280	Phosphorylation	SSPPPPASRLDDEDG CCCCCCHHHCCCCCC	38.87	30108239
338	Phosphorylation	PLEELLRSLPPQLLE CHHHHHHCCCHHHHC	45.24	23663014
348	Phosphorylation	PQLLEGPSSPSQTPS HHHHCCCCCCCCCCC	66.78	23401153
349	Phosphorylation	QLLEGPSSPSQTPSS HHHCCCCCCCCCCCC	31.53	23663014
351	Phosphorylation	LEGPSSPSQTPSSHD HCCCCCCCCCCCCCC	48.94	23663014
353	Phosphorylation	GPSSPSQTPSSHDSD CCCCCCCCCCCCCCC	29.49	23663014
355	Phosphorylation	SSPSQTPSSHDSDTR CCCCCCCCCCCCCCC	43.63	30108239
356	Phosphorylation	SPSQTPSSHDSDTRD CCCCCCCCCCCCCCC	32.30	30108239
359	Phosphorylation	QTPSSHDSDTRDGPE CCCCCCCCCCCCCCC	35.14	27251275
361	Phosphorylation	PSSHDSDTRDGPEEG CCCCCCCCCCCCCCC	34.31	27251275
384	Phosphorylation	LEIKPPPSAVTQRNK EEECCCCCHHCCCCC	40.94	28555341
404	Phosphorylation	DEDDEEFTANEEEAE CCCCCCCCCCHHHHC	31.67	-
562	Phosphorylation	LARDEEQSEADAGSG EECCHHHCHHHCCCC	37.72	29255136
568	Phosphorylation	QSEADAGSGPPTPGP HCHHHCCCCCCCCCC	50.26	29255136
572	Phosphorylation	DAGSGPPTPGPTTLG HCCCCCCCCCCCCCC	43.97	29255136
576	Phosphorylation	GPPTPGPTTLGPKKE CCCCCCCCCCCCCHH	40.34	29255136
577	Phosphorylation	PPTPGPTTLGPKKEI CCCCCCCCCCCCHHH	32.62	29255136
581	Ubiquitination	GPTTLGPKKEITDIA CCCCCCCCHHHHHHH	62.33	-
597	Ubiquitination	AAESLQPKGYTLATT HHHHHCCCCEEEEEC	52.14	29967540
607	Ubiquitination	TLATTQVKTPIPLLL EEEECCCCCCHHHHH	38.47	-
636	Ubiquitination	LVTMYEKKLNGILAD HHHHHHHHHHCCCHH	34.93	29967540
703	Ubiquitination	LTYYGAQKERKLKRQ HHHCCHHHHHHHHHC	59.98	29967540
752	Ubiquitination	LDEAQNIKNFKSQRW EECHHHHCCHHHHHH	64.97	21890473
752 (in isoform 1)	Ubiquitination	-	64.97	21890473
752 (in isoform 2)	Ubiquitination	-	64.97	21890473
752 (in isoform 3)	Ubiquitination	-	64.97	21890473
827	Ubiquitination	EYNEGLVKRLHKVLR HHHHHHHHHHHHHHH	55.04	29967540
847	Acetylation	RVKVDVEKQMPKKYE HCCCCHHHHCCCCCH	52.31	20167786
869	Phosphorylation	SKRQRCLYDDFMAQT CCCCCHHHHHHHCCC	19.66	22210691
884	Phosphorylation	TTKETLATGHFMSVI CCHHHHHHHHHHHHH	34.01	22210691
889	Phosphorylation	LATGHFMSVINILMQ HHHHHHHHHHHHHHH	20.92	22210691
956	Phosphorylation	IGLEGRVSRYEADTF ECCCCCCCHHHCCCC	27.99	23403867
979	Phosphorylation	RVLLEVATAPDPPPR HHHEEEECCCCCCCC	43.85	-
1126	Phosphorylation	APPPGSSSLLKPLTV CCCCCCCCCCCCCCC	39.14	24719451
1132	Phosphorylation	SSLLKPLTVPPGYTF CCCCCCCCCCCCCCC	39.22	24043423
1137	Phosphorylation	PLTVPPGYTFPPAAA CCCCCCCCCCCCCCE	15.81	24043423
1138	Phosphorylation	LTVPPGYTFPPAAAT CCCCCCCCCCCCCEE	35.26	24043423
1145	Phosphorylation	TFPPAAATTTSTTTA CCCCCCEECCCCCEE	26.36	24043423
1146	Phosphorylation	FPPAAATTTSTTTAT CCCCCEECCCCCEEE	17.64	24043423
1147	Phosphorylation	PPAAATTTSTTTATA CCCCEECCCCCEEEE	21.52	24043423
1148	Phosphorylation	PAAATTTSTTTATAT CCCEECCCCCEEEEE	22.97	24043423
1149	Phosphorylation	AAATTTSTTTATATT CCEECCCCCEEEEEE	26.52	24043423
1150	Phosphorylation	AATTTSTTTATATTT CEECCCCCEEEEEEC	17.75	24043423
1151	Phosphorylation	ATTTSTTTATATTTA EECCCCCEEEEEECC	23.31	24043423
1153	Phosphorylation	TTSTTTATATTTAVP CCCCCEEEEEECCCC	23.57	24043423
1155	Phosphorylation	STTTATATTTAVPAP CCCEEEEEECCCCCC	21.96	24043423
1156	Phosphorylation	TTTATATTTAVPAPT CCEEEEEECCCCCCC	15.42	24043423
1157	Phosphorylation	TTATATTTAVPAPTP CEEEEEECCCCCCCC	22.69	24043423
1163	Phosphorylation	TTAVPAPTPAPQRLI ECCCCCCCCCCCEEE	33.90	24043423
1172	Phosphorylation	APQRLILSPDMQARL CCCEEEECCCHHCCC	16.32	25159151
1186	Phosphorylation	LPSGEVVSIGQLASL CCCCCEEEHHHHHHH	26.61	-
1192	Phosphorylation	VSIGQLASLAQRPVA EEHHHHHHHHCCCCC	32.60	-
1204	Phosphorylation	PVANAGGSKPLTFQI CCCCCCCCCCEEEEE	30.13	24719451
1205	Acetylation	VANAGGSKPLTFQIQ CCCCCCCCCEEEEEE	47.52	26051181
1219	Phosphorylation	QGNKLTLTGAQVRQL ECCEEEECHHHHHHH	25.82	23532336
1224	Dimethylation	TLTGAQVRQLAVGQP EECHHHHHHHHCCCC	17.45	-
1224	Methylation	TLTGAQVRQLAVGQP EECHHHHHHHHCCCC	17.45	30989435
1232	Dimethylation	QLAVGQPRPLQRNVV HHHCCCCCCCCCCEE	36.35	-
1232	Methylation	QLAVGQPRPLQRNVV HHHCCCCCCCCCCEE	36.35	30763229
1314	Methylation	GVVKIVVRQAPRDGL CEEEEEEEECCCCCC	18.95	115917717
1318	Methylation	IVVRQAPRDGLTPVP EEEEECCCCCCCCCC	54.36	115917721
1322	Phosphorylation	QAPRDGLTPVPPLAP ECCCCCCCCCCCCCC	27.98	24719451
1382	Phosphorylation	LKLVHSPSPEVSASA HHHHCCCCCCCCCCC	36.39	25332170
1388	Phosphorylation	PSPEVSASAPGAAPL CCCCCCCCCCCCCCE	27.73	25332170
1464	Phosphorylation	IPISAPLTVSASGPA EEECCCEEECCCCCE	16.03	26074081
1466	Phosphorylation	ISAPLTVSASGPALL ECCCEEECCCCCEEE	16.10	26074081
1468	Phosphorylation	APLTVSASGPALLTS CCEEECCCCCEEECC	37.49	26074081
1474	Phosphorylation	ASGPALLTSVTPPLA CCCCEEECCCCCCCC	23.23	26074081
1475	Phosphorylation	SGPALLTSVTPPLAP CCCEEECCCCCCCCC	24.78	26074081
1477	Phosphorylation	PALLTSVTPPLAPVV CEEECCCCCCCCCCC	20.96	26074081
1695	Phosphorylation	APTLGGSSPSQTLSL CCCCCCCCCCCEEEC	31.67	26074081
1697	Phosphorylation	TLGGSSPSQTLSLGT CCCCCCCCCEEECCC	37.43	26074081
1699	Phosphorylation	GGSSPSQTLSLGTGN CCCCCCCEEECCCCC	23.74	26074081
1758	Phosphorylation	APPLAPASPVGPAPA CCCCCCCCCCCCCCC	21.04	26074081
1789	Phosphorylation	PASVQTLTLSPAPVP CCCCEEEEECCCCCC	28.69	26074081
1791	Phosphorylation	SVQTLTLSPAPVPTL CCEEEEECCCCCCCC	17.49	26074081
1826	Phosphorylation	QASSLVVSASGAAPL HHHCEEEECCCCCCC	14.83	-
1828	Phosphorylation	SSLVVSASGAAPLPV HCEEEECCCCCCCCE	22.81	-
1845	Acetylation	VSRLPVSKDEPDTLT EECCCCCCCCCCCEE	67.36	26051181
1845	Ubiquitination	VSRLPVSKDEPDTLT EECCCCCCCCCCCEE	67.36	-
1855	Phosphorylation	PDTLTLRSGPPSPPS CCCEEEECCCCCCCC	59.78	30266825
1859	Phosphorylation	TLRSGPPSPPSTATS EEECCCCCCCCCCCC	53.21	25159151
1862	Phosphorylation	SGPPSPPSTATSFGG CCCCCCCCCCCCCCC	33.77	30183078
1863	Phosphorylation	GPPSPPSTATSFGGP CCCCCCCCCCCCCCC	39.46	30183078
1865	Phosphorylation	PSPPSTATSFGGPRP CCCCCCCCCCCCCCC	25.36	30183078
1866	Phosphorylation	SPPSTATSFGGPRPR CCCCCCCCCCCCCCC	21.30	30183078
1882	Phosphorylation	QPPPPPRSPFYLDSL CCCCCCCCCCCHHHH	25.74	30266825
1885	Phosphorylation	PPPRSPFYLDSLEEK CCCCCCCCHHHHHHH	17.00	30266825
1888	Phosphorylation	RSPFYLDSLEEKRKR CCCCCHHHHHHHHHH	34.78	27251275
1892	Ubiquitination	YLDSLEEKRKRQRSE CHHHHHHHHHHHHHH	54.57	-
1940	Phosphorylation	ASPIGPRSPGPSHPT CCCCCCCCCCCCCCC	37.02	22617229
1944	Phosphorylation	GPRSPGPSHPTFWTY CCCCCCCCCCCCCCH	48.27	28450419
1947	Phosphorylation	SPGPSHPTFWTYTEA CCCCCCCCCCCHHHH	26.78	28450419
1950	Phosphorylation	PSHPTFWTYTEAAHR CCCCCCCCHHHHHHH	19.17	28450419
1951	Phosphorylation	SHPTFWTYTEAAHRA CCCCCCCHHHHHHHH	7.99	24117733
1952	Phosphorylation	HPTFWTYTEAAHRAV CCCCCCHHHHHHHHH	16.27	24117733
2117	Phosphorylation	RIFCFILSTRSGGVG CEEEEEEECCCCCCC	19.56	22210691
2118	Phosphorylation	IFCFILSTRSGGVGV EEEEEEECCCCCCCC	25.96	22210691
2120	Phosphorylation	CFILSTRSGGVGVNL EEEEECCCCCCCCCC	39.73	22210691
2168	Phosphorylation	VHIYRLISERTVEEN HHHHHHHCCCCHHHH	26.14	23403867
2171	Phosphorylation	YRLISERTVEENILK HHHHCCCCHHHHHHH	28.37	23403867
2224	Phosphorylation	PSSSSVPSAPEEEEE CCCCCCCCCCHHHHH	55.06	-
2258	Phosphorylation	EEDIRAATQAKAEQV HHHHHHHHHHHHHHH	28.24	17525332
2310	Phosphorylation	AALVEQLTPIERYAM HHHHHHCCHHHHHHH	23.16	25022875
2323	Phosphorylation	AMKFLEASLEEVSRE HHHHHHHHHHHHCHH	27.26	21815630
2350	Ubiquitination	RKDLDQAKEEVFRLP HHHHHHHHHHHHCCC	49.10	29967540
2370	Phosphorylation	GPGAGDESSCGTGGG CCCCCCCCCCCCCCC	35.35	28165663
2371	Phosphorylation	PGAGDESSCGTGGGT CCCCCCCCCCCCCCC	17.96	27135362
2374	Phosphorylation	GDESSCGTGGGTHRR CCCCCCCCCCCCCCC	36.66	25159151
2378	Phosphorylation	SCGTGGGTHRRSKKA CCCCCCCCCCCCCCC	18.58	30576142
2384	Methylation	GTHRRSKKAKAPERP CCCCCCCCCCCCCCC	57.26	116253001
2393	Phosphorylation	KAPERPGTRVSERLR CCCCCCCCHHHHHHH	30.49	28555341
2396	Phosphorylation	ERPGTRVSERLRGAR CCCCCHHHHHHHHHH	17.44	23532336
2406	Phosphorylation	LRGARAETQGANHTP HHHHHHHCCCCCCCC	31.17	24732914
2412	Phosphorylation	ETQGANHTPVISAHQ HCCCCCCCCCEEEEC	21.04	24732914
2416	O-linked_Glycosylation	ANHTPVISAHQTRST CCCCCCEEEECCCCC	21.67	31492838
2416	O-linked_Glycosylation	ANHTPVISAHQTRST CCCCCCEEEECCCCC	21.67	20068230
2416	Phosphorylation	ANHTPVISAHQTRST CCCCCCEEEECCCCC	21.67	-
2422	Phosphorylation	ISAHQTRSTTTPPRC EEEECCCCCCCCCCC	33.23	24732914
2423	Phosphorylation	SAHQTRSTTTPPRCS EEECCCCCCCCCCCC	31.25	24732914
2424	Phosphorylation	AHQTRSTTTPPRCSP EECCCCCCCCCCCCC	38.25	21712546
2425	Phosphorylation	HQTRSTTTPPRCSPA ECCCCCCCCCCCCCH	31.24	21955146
2430	Phosphorylation	TTTPPRCSPARERVP CCCCCCCCCHHHCCC	23.91	21955146
2601	Phosphorylation	PVSEKNLSLTPSAPS ECCCCCCCCCCCCCC	39.32	26074081
2603	Phosphorylation	SEKNLSLTPSAPSLT CCCCCCCCCCCCCEE	16.30	26074081
2605	Phosphorylation	KNLSLTPSAPSLTLE CCCCCCCCCCCEEEE	47.80	26074081
2608	Phosphorylation	SLTPSAPSLTLEAGS CCCCCCCCEEEEECC	33.43	26074081
2631	Phosphorylation	APDSAEGTTLTVLPE CCCCCCCCEEEECCC	15.33	22468782
2632	Phosphorylation	PDSAEGTTLTVLPEG CCCCCCCEEEECCCC	31.15	22468782
2634	Phosphorylation	SAEGTTLTVLPEGEE CCCCCEEEECCCCCC	20.22	22468782
2673	Phosphorylation	EPLEADRTSEELTEA CCHHCCCCHHHHHHC	40.83	21815630
2674	Phosphorylation	PLEADRTSEELTEAK CHHCCCCHHHHHHCC	29.93	21815630
2682	Phosphorylation	EELTEAKTPTSSPEK HHHHHCCCCCCCCCC	38.56	26074081
2684	Phosphorylation	LTEAKTPTSSPEKPQ HHHCCCCCCCCCCCH	47.25	26074081
2685	Phosphorylation	TEAKTPTSSPEKPQE HHCCCCCCCCCCCHH	45.13	26074081
2686	Phosphorylation	EAKTPTSSPEKPQEL HCCCCCCCCCCCHHC	39.29	26074081
2702	Phosphorylation	TAEVAAPSTSSSATS EEEEECCCCCCCCCC	35.87	30576142
2704	Phosphorylation	EVAAPSTSSSATSSP EEECCCCCCCCCCCC	27.00	30576142
2709	Phosphorylation	STSSSATSSPEGPSP CCCCCCCCCCCCCCC	43.54	30576142
2724	Phosphorylation	ARPPRRRTSADVEIR CCCCCCCCCCCEEEC	26.84	29255136
2725	Phosphorylation	RPPRRRTSADVEIRG CCCCCCCCCCEEECC	22.21	23401153
2771	Methylation	VRRRRQQRGAASTLV HHHHHHHCCCHHHCC	28.51	115917725
2775	Phosphorylation	RQQRGAASTLVPGVS HHHCCCHHHCCCCCC	23.03	23403867
2776	Phosphorylation	QQRGAASTLVPGVSE HHCCCHHHCCCCCCC	27.35	23403867
2782	Phosphorylation	STLVPGVSETSASPG HHCCCCCCCCCCCCC	40.86	30266825
2784	Phosphorylation	LVPGVSETSASPGSP CCCCCCCCCCCCCCC	23.30	30266825
2785	Phosphorylation	VPGVSETSASPGSPS CCCCCCCCCCCCCCC	23.77	30266825
2787	Phosphorylation	GVSETSASPGSPSVR CCCCCCCCCCCCCCC	29.57	29255136
2790	Phosphorylation	ETSASPGSPSVRSMS CCCCCCCCCCCCCCC	19.86	29255136
2792	Phosphorylation	SASPGSPSVRSMSGP CCCCCCCCCCCCCCC	31.68	30266825
2795	Phosphorylation	PGSPSVRSMSGPESS CCCCCCCCCCCCCCC	18.36	30108239
2797	Phosphorylation	SPSVRSMSGPESSPP CCCCCCCCCCCCCCC	53.06	30108239
2801	Phosphorylation	RSMSGPESSPPIGGP CCCCCCCCCCCCCCC	51.80	30108239
2802	Phosphorylation	SMSGPESSPPIGGPC CCCCCCCCCCCCCCC	32.79	30108239
2814	Phosphorylation	GPCEAAPSSSLPTPP CCCCCCCCCCCCCCC	28.03	26074081
2815	Phosphorylation	PCEAAPSSSLPTPPQ CCCCCCCCCCCCCCC	34.53	26074081
2816	Phosphorylation	CEAAPSSSLPTPPQQ CCCCCCCCCCCCCCC	42.58	24719451
2836	Phosphorylation	RHIELGVTGGGSPEN EEEEEECCCCCCCCC	28.45	30266825
2840	Phosphorylation	LGVTGGGSPENGDGA EECCCCCCCCCCCCC	32.11	30266825
2852	Phosphorylation	DGALLAITPPAVKRR CCCEEEECCHHHHCC	20.01	30266825
2869	Phosphorylation	RPPKKNRSPADAGRG CCCCCCCCHHHCCCC	33.56	28355574
2882	Phosphorylation	RGVDEAPSSTLKGKT CCCCCCCCCCCCCCC	42.90	24732914
2883	Phosphorylation	GVDEAPSSTLKGKTN CCCCCCCCCCCCCCC	36.38	21815630
2884	Phosphorylation	VDEAPSSTLKGKTNG CCCCCCCCCCCCCCC	36.51	21815630
2932	Phosphorylation	HRPNPLLSPVEKRRR CCCCCCCCHHHHHHC	34.28	25850435
2953	Phosphorylation	RDLPIPGTISSAGDG CCCCCCCCCCCCCCC	16.60	20639409
2955	Phosphorylation	LPIPGTISSAGDGNS CCCCCCCCCCCCCCC	17.61	20639409
2956	Phosphorylation	PIPGTISSAGDGNSE CCCCCCCCCCCCCCC	32.21	20639409
2962	Phosphorylation	SSAGDGNSESRTQPP CCCCCCCCCCCCCCC	42.34	25159151
2964	Phosphorylation	AGDGNSESRTQPPPH CCCCCCCCCCCCCCC	40.21	25159151
2986	Phosphorylation	PPLLVCPTATVANTV CCEEECCCCEEECEE	29.81	28348404
2988	Phosphorylation	LLVCPTATVANTVTT EEECCCCEEECEEEE	23.72	28348404
2992	Phosphorylation	PTATVANTVTTVTIS CCCEEECEEEEEEEC	14.97	28348404
2994	Phosphorylation	ATVANTVTTVTISTS CEEECEEEEEEECCC	17.32	28348404
2995	Phosphorylation	TVANTVTTVTISTSP EEECEEEEEEECCCC	16.00	28348404
2997	Phosphorylation	ANTVTTVTISTSPPK ECEEEEEEECCCCCC	13.71	28348404
2999	Phosphorylation	TVTTVTISTSPPKRK EEEEEEECCCCCCCC	17.29	28348404
3000	Phosphorylation	VTTVTISTSPPKRKR EEEEEECCCCCCCCC	41.21	28348404
3001	Phosphorylation	TTVTISTSPPKRKRG EEEEECCCCCCCCCC	32.20	25159151
3016	Phosphorylation	RPPKNPPSPRPSQLP CCCCCCCCCCHHHCC	34.49	29255136
3020	Phosphorylation	NPPSPRPSQLPVLDR CCCCCCHHHCCCCCC	45.70	29255136
3029	Phosphorylation	LPVLDRDSTSVLESC CCCCCCCCCHHHHHC	24.39	26552605
3030	Phosphorylation	PVLDRDSTSVLESCG CCCCCCCCHHHHHCC	27.43	26552605
3031	Phosphorylation	VLDRDSTSVLESCGL CCCCCCCHHHHHCCC	28.76	26552605
3035	Phosphorylation	DSTSVLESCGLGRRR CCCHHHHHCCCCCCC	14.88	21815630
3050	Phosphorylation	QPQGQGESEGSSSDE CCCCCCCCCCCCCCC	54.83	21406692
3053	Phosphorylation	GQGESEGSSSDEDGS CCCCCCCCCCCCCCC	23.71	24275569
3054	Phosphorylation	QGESEGSSSDEDGSR CCCCCCCCCCCCCCC	53.30	24275569
3055	Phosphorylation	GESEGSSSDEDGSRP CCCCCCCCCCCCCCC	46.87	24275569
3060	Phosphorylation	SSSDEDGSRPLTRLA CCCCCCCCCCHHHHH	42.94	21406692
3064	Phosphorylation	EDGSRPLTRLARLRL CCCCCCHHHHHHHHH	26.73	21406692
3077	Methylation	RLEAEGMRGRKSGGS HHHHCCCCCCCCCCC	53.25	115917729
3099	Phosphorylation	DDLDLADSGPGGLEL CCCCCCCCCCCCCCC	41.08	28674151
3107	Phosphorylation	GPGGLELTPPVVSLT CCCCCCCCCCEEECC	19.03	28674151
3112	Phosphorylation	ELTPPVVSLTPKLRS CCCCCEEECCCCCCC	27.10	28674151
3114	Phosphorylation	TPPVVSLTPKLRSTR CCCEEECCCCCCCCC	15.75	28674151
3126	Phosphorylation	STRLRPGSLVPPLET CCCCCCCCCCCCCCC	28.95	28555341
3140	Methylation	TEKLPRKRAGAPVGG CCCCCCCCCCCCCCC	39.26	115917733
3148	Phosphorylation	AGAPVGGSPGLAKRG CCCCCCCCCCHHHCC	15.18	29255136
3153	Acetylation	GGSPGLAKRGRLQPP CCCCCHHHCCCCCCC	61.50	25953088
3161	Phosphorylation	RGRLQPPSPLGPEGS CCCCCCCCCCCCCCC	39.17	30278072
3168	Phosphorylation	SPLGPEGSVEESEAE CCCCCCCCCCHHHHH	25.37	30278072
3172	Phosphorylation	PEGSVEESEAEASGE CCCCCCHHHHHHHCC	28.71	30278072
3177	Phosphorylation	EESEAEASGEEEEGD CHHHHHHHCCCCCCC	37.94	30278072
3186	Phosphorylation	EEEEGDGTPRRRPGP CCCCCCCCCCCCCCC	20.54	20873877
3199	Phosphorylation	GPRRLVGTTNQGDQR CCCCEEEECCCCCHH	18.33	20068231
3200	Phosphorylation	PRRLVGTTNQGDQRI CCCEEEECCCCCHHH	21.44	20068231
3210	Phosphorylation	GDQRILRSSAPPSLA CCHHHHHCCCCHHHC	27.66	27690223
3211	Phosphorylation	DQRILRSSAPPSLAG CHHHHHCCCCHHHCC	38.06	27251275
3215	Phosphorylation	LRSSAPPSLAGPAVS HHCCCCHHHCCCCCC	29.77	27251275
3222	Phosphorylation	SLAGPAVSHRGRKAK HHCCCCCCCCCCCCC	15.01	27251275
3224	Methylation	AGPAVSHRGRKAKT- CCCCCCCCCCCCCC-	38.82	115917737
3226	Methylation	PAVSHRGRKAKT--- CCCCCCCCCCCC---	35.40	115917741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRCAP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRCAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRCAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CARM1_HUMAN	CARM1	physical	14500758
EP300_HUMAN	EP300	physical	11581372
CBP_HUMAN	CREBBP	physical	11581372
CBP_HUMAN	CREBBP	physical	10347196
EP300_HUMAN	EP300	physical	10347196
ANDR_HUMAN	AR	physical	20432434
VPS72_HUMAN	VPS72	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
136140	Floating-Harbor syndrome (FLHS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRCAP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-562; SER-568;THR-572; SER-2787; SER-2790; SER-3148; SER-3161; SER-3172 ANDSER-3177, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-2787; SER-2790;SER-3148; SER-3168 AND SER-3177, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2425 AND SER-2430, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248 AND THR-2258, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2869 AND SER-3148, ANDMASS SPECTROMETRY.	17081983 [Abstract]