MA7D2_HUMAN - dbPTM
MA7D2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MA7D2_HUMAN
UniProt AC Q96T17
Protein Name MAP7 domain-containing protein 2
Gene Name MAP7D2
Organism Homo sapiens (Human).
Sequence Length 732
Subcellular Localization
Protein Description
Protein Sequence MERGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFNSPGQETPLNTFC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1 (in isoform 5)Acetylation-7.7522814378
3Methylation-----MERGGGGSGT
-----CCCCCCCCCC		48.00115482567
8PhosphorylationMERGGGGSGTGSRPE
CCCCCCCCCCCCCCC		36.1329449344
10PhosphorylationRGGGGSGTGSRPEGT
CCCCCCCCCCCCCCC		33.4129449344
12PhosphorylationGGGSGTGSRPEGTAR
CCCCCCCCCCCCCCC		44.4929449344
17PhosphorylationTGSRPEGTARGTSLP
CCCCCCCCCCCCCCC		16.12-
19MethylationSRPEGTARGTSLPGK
CCCCCCCCCCCCCCC		49.0897770671
134PhosphorylationLEAMMRRSLERTQQL
HHHHHHHHHHHHHHH		24.9826437602
142 (in isoform 5)Phosphorylation-54.9623663014
143 (in isoform 5)Phosphorylation-15.5723663014
144 (in isoform 5)Phosphorylation-37.5323663014
145 (in isoform 5)Phosphorylation-70.3523663014
147PhosphorylationQLELKKKYSWGAPLA
HHHHHHHHCCCCCEE		20.6627251275
148PhosphorylationLELKKKYSWGAPLAI
HHHHHHHCCCCCEEE		28.1028857561
148 (in isoform 2)Phosphorylation-28.1027251275
149 (in isoform 5)Phosphorylation-12.1323663014
150 (in isoform 5)Phosphorylation-16.0423663014
151 (in isoform 5)Phosphorylation-6.9523663014
163 (in isoform 5)Phosphorylation-6.2123663014
164 (in isoform 5)Phosphorylation-57.5623663014
167PhosphorylationHDACDKLSTSTMSLP
HHHHHHCCCCCCCCC		26.5029396449
168PhosphorylationDACDKLSTSTMSLPK
HHHHHCCCCCCCCCC		38.3629396449
169PhosphorylationACDKLSTSTMSLPKP
HHHHCCCCCCCCCCC		20.8027251275
170PhosphorylationCDKLSTSTMSLPKPT
HHHCCCCCCCCCCCC		15.7429396449
172PhosphorylationKLSTSTMSLPKPTEP
HCCCCCCCCCCCCCC		41.4227251275
172 (in isoform 2)Phosphorylation-41.4227251275
175UbiquitinationTSTMSLPKPTEPPMN
CCCCCCCCCCCCCCC		70.6221890473
175UbiquitinationTSTMSLPKPTEPPMN
CCCCCCCCCCCCCCC		70.6221890473
177PhosphorylationTMSLPKPTEPPMNKR
CCCCCCCCCCCCCCC		68.2229396449
186PhosphorylationPPMNKRLSSSTVAIS
CCCCCCCCCCEEEEE		26.6925850435
186 (in isoform 2)Phosphorylation-26.6927251275
187PhosphorylationPMNKRLSSSTVAISY
CCCCCCCCCEEEEEE		34.3222496350
187 (in isoform 2)Phosphorylation-34.3224719451
188PhosphorylationMNKRLSSSTVAISYS
CCCCCCCCEEEEEEC		24.4326657352
189PhosphorylationNKRLSSSTVAISYSP
CCCCCCCEEEEEECC		18.8626657352
193PhosphorylationSSSTVAISYSPDRVF
CCCEEEEEECCCHHE		15.1527732954
194PhosphorylationSSTVAISYSPDRVFH
CCEEEEEECCCHHEE		20.3627732954
195PhosphorylationSTVAISYSPDRVFHV
CEEEEEECCCHHEEE		17.3421955146
195 (in isoform 2)Phosphorylation-17.3427251275
215PhosphorylationPLGPLNPSYKSSPTR
CCCCCCCCCCCCCCC		44.0828857561
216PhosphorylationLGPLNPSYKSSPTRN
CCCCCCCCCCCCCCC		19.0223663014
217UbiquitinationGPLNPSYKSSPTRNI
CCCCCCCCCCCCCCC		49.1221890473
217UbiquitinationGPLNPSYKSSPTRNI
CCCCCCCCCCCCCCC		49.122189047
217 (in isoform 1)Ubiquitination-49.1221890473
217 (in isoform 2)Phosphorylation-49.1228674419
218PhosphorylationPLNPSYKSSPTRNIE
CCCCCCCCCCCCCCC		33.0622617229
219PhosphorylationLNPSYKSSPTRNIEK
CCCCCCCCCCCCCCC		26.5823312004
221PhosphorylationPSYKSSPTRNIEKKK
CCCCCCCCCCCCCCC		37.9923312004
230PhosphorylationNIEKKKATSTSTSGA
CCCCCCCCCCCCCCC		41.2228857561
231PhosphorylationIEKKKATSTSTSGAG
CCCCCCCCCCCCCCC		25.8121955146
232PhosphorylationEKKKATSTSTSGAGD
CCCCCCCCCCCCCCH		31.5021955146
233PhosphorylationKKKATSTSTSGAGDV
CCCCCCCCCCCCCHH		21.9721955146
234PhosphorylationKKATSTSTSGAGDVG
CCCCCCCCCCCCHHH		31.1323312004
235PhosphorylationKATSTSTSGAGDVGK
CCCCCCCCCCCHHHH		26.8123312004
246PhosphorylationDVGKEALSGGEASLV
HHHHHHHCCCCHHHH		52.3725850435
251PhosphorylationALSGGEASLVEKVKR
HHCCCCHHHHHHHHC		28.7527732954
258 (in isoform 2)Ubiquitination-49.8421890473
262PhosphorylationKVKRGQRTATSLPVV
HHHCCCCCCCCCCEE		26.8027174698
264PhosphorylationKRGQRTATSLPVVNF
HCCCCCCCCCCEECC		30.1327174698
265PhosphorylationRGQRTATSLPVVNFG
CCCCCCCCCCEECCC		28.3627174698
273PhosphorylationLPVVNFGSPLRRCEF
CCEECCCCCCCCCEE		19.3427987026
281PhosphorylationPLRRCEFSGGIPKRP
CCCCCEECCCCCCCC		17.5127174698
289PhosphorylationGGIPKRPSSPVISKT
CCCCCCCCCCCCCCC		51.8426657352
290PhosphorylationGIPKRPSSPVISKTA
CCCCCCCCCCCCCCC		26.3521955146
294PhosphorylationRPSSPVISKTATKAY
CCCCCCCCCCCCCCC		24.9624117733
304PhosphorylationATKAYPQSPKTTKPP
CCCCCCCCCCCCCCC		24.7024719451
307PhosphorylationAYPQSPKTTKPPYPG
CCCCCCCCCCCCCCC		43.3628857561
308PhosphorylationYPQSPKTTKPPYPGS
CCCCCCCCCCCCCCC		47.9128857561
312PhosphorylationPKTTKPPYPGSPVKY
CCCCCCCCCCCCCCC		28.8426657352
314 (in isoform 2)Phosphorylation-38.4424719451
315PhosphorylationTKPPYPGSPVKYRLP
CCCCCCCCCCCCCCC		23.2426657352
319PhosphorylationYPGSPVKYRLPALSG
CCCCCCCCCCCCCCC		20.0223312004
331 (in isoform 2)Phosphorylation-60.9524719451
341AcetylationAEKEKSNKEREGTLA
HHHHHHHHHHHCCHH		66.3019822353
345 (in isoform 2)Phosphorylation-32.0524719451
350AcetylationREGTLAQQAAGPQGE
HHCCHHHHHHCHHHH		27.8019608861
356 (in isoform 2)Phosphorylation-37.5327251275
357AcetylationQAAGPQGEEALEKHV
HHHCHHHHHHHHHHC		34.5419608861
402AcetylationTDAGEAAKILAEKRR
CCHHHHHHHHHHHHH		45.3523954790
443AcetylationLKRKAEEERLRLEEE
HHHHHHHHHHHHHHH		48.8219608861
543MethylationERLERKKRIDEIMKR
HHHHHHHHHHHHHHH		44.63115482571
549AcetylationKRIDEIMKRTRKSDV
HHHHHHHHHHHHCCC		57.1730590289
554PhosphorylationIMKRTRKSDVSPQVK
HHHHHHHCCCCCCCC		39.7028509920
557PhosphorylationRTRKSDVSPQVKKED
HHHHCCCCCCCCCCC		18.0125599653
634PhosphorylationLDALDGKSNSLDDST
HHHCCCCCCCCCCCC		36.8627251275
636PhosphorylationALDGKSNSLDDSTEE
HCCCCCCCCCCCCHH		40.0229978859
640PhosphorylationKSNSLDDSTEEVQSM
CCCCCCCCCHHHHHC		37.0726657352
641PhosphorylationSNSLDDSTEEVQSMD
CCCCCCCCHHHHHCC		43.0626657352
646PhosphorylationDSTEEVQSMDVSPVS
CCCHHHHHCCCCCCC		23.3327251275
650PhosphorylationEVQSMDVSPVSKEEL
HHHHCCCCCCCHHHH		18.4729978859
653PhosphorylationSMDVSPVSKEELISI
HCCCCCCCHHHHCCC		37.4229978859
667PhosphorylationIPEFSPVSEMIPGVS
CCCCCCHHHCCCCCC		25.4926657352
677 (in isoform 2)Phosphorylation-56.3927251275
681 (in isoform 2)Phosphorylation-27.4827251275
691 (in isoform 2)Phosphorylation-46.4927251275
702PhosphorylationPPTFPKRSSENLSLD
CCCCCCCCCCCCCHH		48.4027251275
703PhosphorylationPTFPKRSSENLSLDD
CCCCCCCCCCCCHHH		34.2421955146
707PhosphorylationKRSSENLSLDDCNKN
CCCCCCCCHHHHCCC		41.1429449344
721PhosphorylationNLIEGFNSPGQETPL
CHHHCCCCCCCCCCC		28.3129632367
726PhosphorylationFNSPGQETPLNTFC-
CCCCCCCCCCCCCC-		25.7827251275
730PhosphorylationGQETPLNTFC-----
CCCCCCCCCC-----		33.7827251275
744 (in isoform 2)Phosphorylation-27251275
767 (in isoform 2)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MA7D2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MA7D2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MA7D2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KI20A_HUMANKIF20Aphysical
28514442
BEND3_HUMANBEND3physical
28514442
NEUL4_HUMANNEURL4physical
28514442
HERC2_HUMANHERC2physical
28514442
UBP20_HUMANUSP20physical
28514442
UBE3A_HUMANUBE3Aphysical
28514442
EPN4_HUMANCLINT1physical
28514442
LONP2_HUMANLONP2physical
28514442
ECI2_HUMANECI2physical
28514442
STX8_HUMANSTX8physical
28514442
TRI27_HUMANTRIM27physical
28514442
KINH_HUMANKIF5Bphysical
28514442
CENPF_HUMANCENPFphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MA7D2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650; SER-653 ANDSER-721, AND MASS SPECTROMETRY.

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