| UniProt ID | KNOP1_HUMAN | |
|---|---|---|
| UniProt AC | Q1ED39 | |
| Protein Name | Lysine-rich nucleolar protein 1 | |
| Gene Name | KNOP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 458 | |
| Subcellular Localization | Nucleus, nucleolus. | |
| Protein Description | ||
| Protein Sequence | MITKTHKVDLGLPEKKKKKKVVKEPETRYSVLNNDDYFADVSPLRATSPSKSVAHGQAPEMPLVKKKKKKKKGVSTLCEEHVEPETTLPARRTEKSPSLRKQVFGHLEFLSGEKKNKKSPLAMSHASGVKTSPDPRQGEEETRVGKKLKKHKKEKKGAQDPTAFSVQDPWFCEAREARDVGDTCSVGKKDEEQAALGQKRKRKSPREHNGKVKKKKKIHQEGDALPGHSKPSRSMESSPRKGSKKKPVKVEAPEYIPISDDPKASAKKKMKSKKKVEQPVIEEPALKRKKKKKRKESGVAGDPWKEETDTDLEVVLEKKGNMDEAHIDQVRRKALQEEIDRESGKTEASETRKWTGTQFGQWDTAGFENEDQKLKFLRLMGGFKNLSPSFSRPASTIARPNMALGKKAADSLQQNLQRDYDRAMSWKYSRGAGLGFSTAPNKIFYIDRNASKSVKLED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MITKTHKVDLGL ---CCCCCCCCCCCC | 28348404 | ||
| 7 | Sumoylation | -MITKTHKVDLGLPE -CCCCCCCCCCCCCC | 28112733 | ||
| 15 | Acetylation | VDLGLPEKKKKKKVV CCCCCCCHHHCCCCC | 26051181 | ||
| 27 | Phosphorylation | KVVKEPETRYSVLNN CCCCCCCHHHHHHCC | 22210691 | ||
| 29 | Phosphorylation | VKEPETRYSVLNNDD CCCCCHHHHHHCCCC | 23403867 | ||
| 30 | Phosphorylation | KEPETRYSVLNNDDY CCCCHHHHHHCCCCC | 23403867 | ||
| 37 | Phosphorylation | SVLNNDDYFADVSPL HHHCCCCCCCCCCCC | 23927012 | ||
| 42 | Phosphorylation | DDYFADVSPLRATSP CCCCCCCCCCCCCCC | 25159151 | ||
| 47 | Phosphorylation | DVSPLRATSPSKSVA CCCCCCCCCCCCCHH | 25159151 | ||
| 48 | Phosphorylation | VSPLRATSPSKSVAH CCCCCCCCCCCCHHC | 25159151 | ||
| 50 | Phosphorylation | PLRATSPSKSVAHGQ CCCCCCCCCCHHCCC | 23927012 | ||
| 52 | Phosphorylation | RATSPSKSVAHGQAP CCCCCCCCHHCCCCC | 25159151 | ||
| 93 | Phosphorylation | TTLPARRTEKSPSLR CCCCCCCCCCCHHHH | 27794612 | ||
| 96 | Phosphorylation | PARRTEKSPSLRKQV CCCCCCCCHHHHHHH | 29496963 | ||
| 98 | Phosphorylation | RRTEKSPSLRKQVFG CCCCCCHHHHHHHHH | 27732954 | ||
| 101 | Sumoylation | EKSPSLRKQVFGHLE CCCHHHHHHHHHHHH | 28112733 | ||
| 101 | Methylation | EKSPSLRKQVFGHLE CCCHHHHHHHHHHHH | - | ||
| 102 | Phosphorylation | KSPSLRKQVFGHLEF CCHHHHHHHHHHHHH | 32142685 | ||
| 108 | Phosphorylation | KQVFGHLEFLSGEKK HHHHHHHHHHCCCCC | 32645325 | ||
| 111 | Phosphorylation | FGHLEFLSGEKKNKK HHHHHHHCCCCCCCC | 25159151 | ||
| 119 | Phosphorylation | GEKKNKKSPLAMSHA CCCCCCCCCCHHHCC | 23927012 | ||
| 124 | Phosphorylation | KKSPLAMSHASGVKT CCCCCHHHCCCCCCC | 23927012 | ||
| 127 | Phosphorylation | PLAMSHASGVKTSPD CCHHHCCCCCCCCCC | 23927012 | ||
| 130 | Sumoylation | MSHASGVKTSPDPRQ HHCCCCCCCCCCCCC | 28112733 | ||
| 131 | Phosphorylation | SHASGVKTSPDPRQG HCCCCCCCCCCCCCC | 23927012 | ||
| 132 | Phosphorylation | HASGVKTSPDPRQGE CCCCCCCCCCCCCCH | 23401153 | ||
| 142 | Phosphorylation | PRQGEEETRVGKKLK CCCCHHHHHHHHHHH | 26074081 | ||
| 165 | Phosphorylation | AQDPTAFSVQDPWFC CCCCCCCCCCCCCHH | - | ||
| 183 | Phosphorylation | EARDVGDTCSVGKKD HHCCCCCCCCCCCHH | 25849741 | ||
| 185 | Phosphorylation | RDVGDTCSVGKKDEE CCCCCCCCCCCHHHH | 23401153 | ||
| 188 | Acetylation | GDTCSVGKKDEEQAA CCCCCCCCHHHHHHH | 26051181 | ||
| 188 | 2-Hydroxyisobutyrylation | GDTCSVGKKDEEQAA CCCCCCCCHHHHHHH | - | ||
| 189 | Acetylation | DTCSVGKKDEEQAAL CCCCCCCHHHHHHHH | 26051181 | ||
| 199 | 2-Hydroxyisobutyrylation | EQAALGQKRKRKSPR HHHHHHHHCCCCCCC | - | ||
| 203 | Acetylation | LGQKRKRKSPREHNG HHHHCCCCCCCCCCC | 7670977 | ||
| 211 | Acetylation | SPREHNGKVKKKKKI CCCCCCCCCCCCCCC | 7670985 | ||
| 229 | Phosphorylation | GDALPGHSKPSRSME CCCCCCCCCCCCCCC | 26074081 | ||
| 232 | Phosphorylation | LPGHSKPSRSMESSP CCCCCCCCCCCCCCC | 24719451 | ||
| 234 | Phosphorylation | GHSKPSRSMESSPRK CCCCCCCCCCCCCCC | 29396449 | ||
| 237 | Phosphorylation | KPSRSMESSPRKGSK CCCCCCCCCCCCCCC | 33259812 | ||
| 238 | Phosphorylation | PSRSMESSPRKGSKK CCCCCCCCCCCCCCC | 30576142 | ||
| 246 | Sumoylation | PRKGSKKKPVKVEAP CCCCCCCCCCEEECC | - | ||
| 249 | Sumoylation | GSKKKPVKVEAPEYI CCCCCCCEEECCCCC | 25114211 | ||
| 255 | Phosphorylation | VKVEAPEYIPISDDP CEEECCCCCCCCCCC | 28796482 | ||
| 259 | Phosphorylation | APEYIPISDDPKASA CCCCCCCCCCCCHHH | 28796482 | ||
| 265 | Phosphorylation | ISDDPKASAKKKMKS CCCCCCHHHHHHHHC | 29255136 | ||
| 275 | Sumoylation | KKMKSKKKVEQPVIE HHHHCCCCCCCCCCC | - | ||
| 275 | Sumoylation | KKMKSKKKVEQPVIE HHHHCCCCCCCCCCC | 28112733 | ||
| 287 | Sumoylation | VIEEPALKRKKKKKR CCCCHHHHHHHHHHH | 28112733 | ||
| 297 | Phosphorylation | KKKKRKESGVAGDPW HHHHHHHCCCCCCCC | 23927012 | ||
| 305 | Sumoylation | GVAGDPWKEETDTDL CCCCCCCCCCCCCCH | 28112733 | ||
| 308 | Phosphorylation | GDPWKEETDTDLEVV CCCCCCCCCCCHHHH | 30266825 | ||
| 310 | Phosphorylation | PWKEETDTDLEVVLE CCCCCCCCCHHHHHH | 30266825 | ||
| 319 | Sumoylation | LEVVLEKKGNMDEAH HHHHHHCCCCCCHHH | 28112733 | ||
| 319 | Sumoylation | LEVVLEKKGNMDEAH HHHHHHCCCCCCHHH | - | ||
| 341 | Methylation | ALQEEIDRESGKTEA HHHHHHHHHHCCCCC | 115481355 | ||
| 343 | Phosphorylation | QEEIDRESGKTEASE HHHHHHHHCCCCCHH | 25849741 | ||
| 346 | Phosphorylation | IDRESGKTEASETRK HHHHHCCCCCHHHHC | 28555341 | ||
| 353 | Ubiquitination | TEASETRKWTGTQFG CCCHHHHCCCCCCCC | 29967540 | ||
| 353 | Sumoylation | TEASETRKWTGTQFG CCCHHHHCCCCCCCC | 28112733 | ||
| 355 | Phosphorylation | ASETRKWTGTQFGQW CHHHHCCCCCCCCCC | 24114839 | ||
| 357 | Phosphorylation | ETRKWTGTQFGQWDT HHHCCCCCCCCCCCC | 24114839 | ||
| 373 | Ubiquitination | GFENEDQKLKFLRLM CCCCHHHHHHHHHHC | 29967540 | ||
| 373 | Sumoylation | GFENEDQKLKFLRLM CCCCHHHHHHHHHHC | - | ||
| 373 | Sumoylation | GFENEDQKLKFLRLM CCCCHHHHHHHHHHC | 28112733 | ||
| 375 | Sumoylation | ENEDQKLKFLRLMGG CCHHHHHHHHHHCCC | 28112733 | ||
| 387 | Phosphorylation | MGGFKNLSPSFSRPA CCCCCCCCCCCCCCH | 30266825 | ||
| 389 | Phosphorylation | GFKNLSPSFSRPAST CCCCCCCCCCCCHHH | 30266825 | ||
| 391 | Phosphorylation | KNLSPSFSRPASTIA CCCCCCCCCCHHHCC | 30266825 | ||
| 406 | Acetylation | RPNMALGKKAADSLQ CCHHHHCHHHHHHHH | 25953088 | ||
| 407 | Sumoylation | PNMALGKKAADSLQQ CHHHHCHHHHHHHHH | 28112733 | ||
| 407 | Ubiquitination | PNMALGKKAADSLQQ CHHHHCHHHHHHHHH | 29967540 | ||
| 407 | Sumoylation | PNMALGKKAADSLQQ CHHHHCHHHHHHHHH | - | ||
| 411 | Phosphorylation | LGKKAADSLQQNLQR HCHHHHHHHHHHHHH | 20068231 | ||
| 420 | Phosphorylation | QQNLQRDYDRAMSWK HHHHHHHHHHHHHHH | - | ||
| 425 | Phosphorylation | RDYDRAMSWKYSRGA HHHHHHHHHHHHCCC | 20860994 | ||
| 427 | Sumoylation | YDRAMSWKYSRGAGL HHHHHHHHHHCCCCC | - | ||
| 427 | Sumoylation | YDRAMSWKYSRGAGL HHHHHHHHHHCCCCC | - | ||
| 428 | Phosphorylation | DRAMSWKYSRGAGLG HHHHHHHHHCCCCCC | 29759185 | ||
| 429 | Phosphorylation | RAMSWKYSRGAGLGF HHHHHHHHCCCCCCC | - | ||
| 430 | Methylation | AMSWKYSRGAGLGFS HHHHHHHCCCCCCCC | 24129315 | ||
| 442 | Acetylation | GFSTAPNKIFYIDRN CCCCCCCEEEEECCC | 26051181 | ||
| 442 | Sumoylation | GFSTAPNKIFYIDRN CCCCCCCEEEEECCC | 28112733 | ||
| 442 | Sumoylation | GFSTAPNKIFYIDRN CCCCCCCEEEEECCC | - | ||
| 448 | Methylation | NKIFYIDRNASKSVK CEEEEECCCCCCCCC | 115481363 | ||
| 455 | Sumoylation | RNASKSVKLED---- CCCCCCCCCCC---- | - | ||
| 455 | Sumoylation | RNASKSVKLED---- CCCCCCCCCCC---- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KNOP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KNOP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KNOP1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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