SHQ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHQ1_HUMAN
• UniProt AC: Q6PI26
• Protein Name: Protein SHQ1 homolog
• Gene Name: SHQ1
• Organism: Homo sapiens (Human).
• Sequence Length: 577
• Subcellular Localization: Cytoplasm, cytosol . Nucleus, nucleoplasm . May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription
• Protein Description: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA..
• Protein Sequence: MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIHKIFQENDPAYILNDLYISDYCVWIQKVKSKKLAALAEALKEVSLTKAQLGLELEELEAAALLVQEEETALKAAHSVSGQQTLCSSSEASDSEDSDSSVSSGNEDSGSDSEQDELKDSPSETVSSLQGPFLEESSAFLIVDGGVRRNTAIQESDASQGKPLASSWPLGVSGPLIEELGEQLKTTVQVSEPKGTTAVNRSNIQERDGCQTPNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLTPAFDLSQ -----CCCCCCCCCC	15.98	24043423
9	Phosphorylation	LTPAFDLSQDPDFLT CCCCCCCCCCCCCEE	34.09	24043423
16	Phosphorylation	SQDPDFLTIAIRVPY CCCCCCEEEEEECCC	14.35	24043423
23	Phosphorylation	TIAIRVPYARVSEFD EEEEECCCCEECEEE	12.27	24043423
27	Phosphorylation	RVPYARVSEFDVYFE ECCCCEECEEEEEEE	27.30	24043423
32	Phosphorylation	RVSEFDVYFEGSDFK EECEEEEEEECCCCE	9.58	24043423
36	Phosphorylation	FDVYFEGSDFKFYAK EEEEEECCCCEEEEE	32.45	24043423
39	Ubiquitination	YFEGSDFKFYAKPYF EEECCCCEEEEEEEE	42.32	22817900
41	Ubiquitination	EGSDFKFYAKPYFLR ECCCCEEEEEEEEEE	17.82	-
43	Ubiquitination	SDFKFYAKPYFLRLT CCCEEEEEEEEEEEE	28.95	21906983
69	Ubiquitination	QGSYDADKGIFTIRL CCCEECCCCEEEEEC	56.48	21906983
73	Phosphorylation	DADKGIFTIRLPKET ECCCCEEEEECCCCC	11.85	24719451
144	Ubiquitination	VSESALNPQCHYGFG CCHHHCCCCCCCCCC	38.74	-
172	Ubiquitination	LSDVIDIKDPDFTPA HCCCCCCCCCCCCHH	60.50	29967540
194	Ubiquitination	LAAELAKFDPDHYLA HHHHHHCCCCCCHHH	15.96	21890473
222	Ubiquitination	YNPWWTDKYSKMMAF HCCHHHHHHHHHHHH	44.01	21890473
225	Ubiquitination	WWTDKYSKMMAFLEK HHHHHHHHHHHHHHH	29.61	29967540
231	Ubiquitination	SKMMAFLEKSQEQEN HHHHHHHHHHHHHHH	44.18	-
237	Ubiquitination	LEKSQEQENHATLVS HHHHHHHHHCCEEEE	50.67	-
250	Ubiquitination	VSFSEEEKYQLRKFV EECCHHHHHHHHHHH	41.39	29967540
251	Phosphorylation	SFSEEEKYQLRKFVN ECCHHHHHHHHHHHC	18.96	-
259	Ubiquitination	QLRKFVNKSYLLDKR HHHHHHCHHHHCCHH	34.87	29967540
261	Phosphorylation	RKFVNKSYLLDKRAC HHHHCHHHHCCHHHH	16.94	-
265	Ubiquitination	NKSYLLDKRACRQVC CHHHHCCHHHHHHHH	41.69	-
265	Ubiquitination	NKSYLLDKRACRQVC CHHHHCCHHHHHHHH	41.69	-
293	Ubiquitination	TRVTEGEKNVESAWN CCCCCCCCCHHHHHH	76.72	-
313	Phosphorylation	PTLCWFETWTNVHDI CCEEEEECCCCHHHH	28.28	22210691
315	Phosphorylation	LCWFETWTNVHDIMV EEEEECCCCHHHHHH	34.48	22210691
323	Phosphorylation	NVHDIMVSFGRRVLC CHHHHHHHCCCHHHH	12.47	22210691
355	Ubiquitination	IKILQLGKSAVLKCL HHHHHHCHHHHHHHH	43.78	27667366
378	Ubiquitination	ENDPAYILNDLYISD HCCCHHHHCCEEHHC	2.38	-
397	Malonylation	IQKVKSKKLAALAEA HHHHCHHHHHHHHHH	50.91	26320211
397	Acetylation	IQKVKSKKLAALAEA HHHHCHHHHHHHHHH	50.91	25953088
406	Ubiquitination	AALAEALKEVSLTKA HHHHHHHHHHCCCHH	64.22	-
473	Phosphorylation	SGNEDSGSDSEQDEL CCCCCCCCHHHCHHH	41.75	-
475	Phosphorylation	NEDSGSDSEQDELKD CCCCCCHHHCHHHCC	38.56	-
528	Phosphorylation	SQGKPLASSWPLGVS CCCCCCHHCCCCCCC	40.39	-
529	Phosphorylation	QGKPLASSWPLGVSG CCCCCHHCCCCCCCC	27.40	30576142
549	Phosphorylation	LGEQLKTTVQVSEPK HHHHHCCEEEECCCC	13.83	28851738
553	Phosphorylation	LKTTVQVSEPKGTTA HCCEEEECCCCCCCC	30.96	28851738
558	Phosphorylation	QVSEPKGTTAVNRSN EECCCCCCCCCCHHC	20.08	28851738
559	Phosphorylation	VSEPKGTTAVNRSNI ECCCCCCCCCCHHCC	36.96	28851738
564	Phosphorylation	GTTAVNRSNIQERDG CCCCCCHHCCCCCCC	32.83	25159151
574	Phosphorylation	QERDGCQTPNN---- CCCCCCCCCCC----	31.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHQ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHQ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHQ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAF1_HUMAN	NAF1	physical	21931644
SHQ1_HUMAN	SHQ1	physical	21931644
GMCL1_HUMAN	GMCL1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.