IFT80_HUMAN - dbPTM
IFT80_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IFT80_HUMAN
UniProt AC Q9P2H3
Protein Name Intraflagellar transport protein 80 homolog
Gene Name IFT80
Organism Homo sapiens (Human).
Sequence Length 777
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Basal body and ciliary axoneme..
Protein Description Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia..
Protein Sequence MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVEQHWEWKNFQVTLTKRRAMQVRNVLNDAVDLLEFRDRVIKASLNYAHLVVSTSLQCYVFSTKNWNTPIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDILNAQTVSLSNDTIAIRDKADEKIIFLFEASTGKPLGDGKFLSHKNEILEIALDQKGLTNDRKIAFIDKNRDLCITSVKRFGKEEQIIKLGTMVHTLAWNDTCNILCGLQDTRFIVWYYPNTVYVDRDILPKTLYERDASEFSKNPHIVSFVGNQVTIRRADGSLVHISITPYPAILHEYVSSSKWEDAVRLCRFVKEQTMWACLAAMAVANRDMTTAEIAYAAIGEIDKVQYINSIKNLPSKESKMAHILLFSGNIQEAEIVLLQAGLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQKFLETFGKQETNKRYLHYAEGLQIDWEKIKAKIEMEITKEREQSSSSQSSKSIGLKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MRLKISLLKEPKH
--CCCEEEECCCCCH		26.5124719451
9UbiquitinationRLKISLLKEPKHQEL
CCEEEECCCCCHHHH		76.8029967540
79PhosphorylationKKQTQAESFVLTSSD
CCCCCCCEEEEECCC		24.54-
141PhosphorylationSKTGMLRSTLAQQGT
ECCCCCHHHHHHCCC		24.6629900121
142PhosphorylationKTGMLRSTLAQQGTP
CCCCCHHHHHHCCCC		21.4829900121
148PhosphorylationSTLAQQGTPVYSVAW
HHHHHCCCCEEEEEE		12.7829900121
152PhosphorylationQQGTPVYSVAWGPDS
HCCCCEEEEEECCCH		12.9529900121
198PhosphorylationILKVDWNSVNDLILS
EEEECHHHHHHHHHH		20.3123612710
205PhosphorylationSVNDLILSAGEDCKY
HHHHHHHHCCCCCCE		27.5123612710
212PhosphorylationSAGEDCKYKVWDSYG
HCCCCCCEEEECCCC		19.67-
217PhosphorylationCKYKVWDSYGRPLYN
CCEEEECCCCCCCCC		17.49-
341PhosphorylationRDRVIKASLNYAHLV
HHHHHHHHCCCCEEE		16.4929083192
344PhosphorylationVIKASLNYAHLVVST
HHHHHCCCCEEEEEE		10.7429083192
347UbiquitinationASLNYAHLVVSTSLQ
HHCCCCEEEEEECEE		2.8729967540
350PhosphorylationNYAHLVVSTSLQCYV
CCCEEEEEECEEEEE		12.5629083192
351PhosphorylationYAHLVVSTSLQCYVF
CCEEEEEECEEEEEE		23.1129083192
352PhosphorylationAHLVVSTSLQCYVFS
CEEEEEECEEEEEEE		14.6729083192
414PhosphorylationPKFPGMRTDILNAQT
CCCCCCCCCCCCCEE		20.6424719451
423PhosphorylationILNAQTVSLSNDTIA
CCCCEEEECCCCEEE		29.4824719451
428PhosphorylationTVSLSNDTIAIRDKA
EEECCCCEEEEECCC		19.2924719451
484UbiquitinationRKIAFIDKNRDLCIT
CEEEEEECCCCEEEE		49.4129967540
588PhosphorylationVHISITPYPAILHEY
EEEEEECCCHHHHHH		9.17-
637PhosphorylationMTTAEIAYAAIGEID
CCHHHHHHHHHCCCC		11.3922210691
648PhosphorylationGEIDKVQYINSIKNL
CCCCEEEEHHHHCCC		12.6920049867
651PhosphorylationDKVQYINSIKNLPSK
CEEEEHHHHCCCCCC		25.9422210691
657PhosphorylationNSIKNLPSKESKMAH
HHHCCCCCCHHHCHH		52.8222210691
660PhosphorylationKNLPSKESKMAHILL
CCCCCCHHHCHHEEE		31.3120049867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IFT80_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IFT80_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IFT80_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IFT52_HUMANIFT52physical
26344197
UBX10_HUMANUBXN10physical
26389662
IF172_HUMANIFT172physical
27173435
IFT88_HUMANIFT88physical
27173435
IFT57_HUMANIFT57physical
27173435
IFT20_HUMANIFT20physical
27173435
MIPT3_HUMANTRAF3IP1physical
27173435
CLUA1_HUMANCLUAP1physical
27173435
IFT74_HUMANIFT74physical
27173435
IFT27_HUMANIFT27physical
27173435
TT30A_HUMANTTC30Aphysical
27173435
IFT22_HUMANIFT22physical
27173435
IFT46_HUMANIFT46physical
27173435
NUDC_HUMANNUDCphysical
27173435
IFT81_HUMANIFT81physical
27173435
TT30B_HUMANTTC30Bphysical
27173435
IFT56_HUMANTTC26physical
27173435
IFT52_HUMANIFT52physical
27173435
IFT25_HUMANHSPB11physical
27173435
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IFT80_HUMAN

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Related Literatures of Post-Translational Modification

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