IFT88_HUMAN - dbPTM
IFT88_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IFT88_HUMAN
UniProt AC Q13099
Protein Name Intraflagellar transport protein 88 homolog
Gene Name IFT88
Organism Homo sapiens (Human).
Sequence Length 833
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body .
Protein Description Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment..
Protein Sequence MKFTNTKVQMMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationPPITAKISSTAVTRP
CCCEEEECCCCCCCC		22.4127251275
71O-linked_GlycosylationKISSTAVTRPIATGY
EECCCCCCCCCCCCC		28.41-
80PhosphorylationPIATGYGSKTSLASS
CCCCCCCCHHHHHHH		25.0327251275
114UbiquitinationVRAAGFTKAALRGSA
HHHCCCCHHHHCCCC		29.42-
120PhosphorylationTKAALRGSAFDPLSQ
CHHHHCCCCCCCCHH		21.2328857561
126PhosphorylationGSAFDPLSQSRGPAS
CCCCCCCHHCCCCCC		31.3428555341
128PhosphorylationAFDPLSQSRGPASPL
CCCCCHHCCCCCCCC		35.5128555341
133PhosphorylationSQSRGPASPLEAKKK
HHCCCCCCCCHHHCC		32.9029255136
161PhosphorylationVNELVEESCIANSCG
HHHHHHHHHHHCCCC		9.4127251275
166PhosphorylationEESCIANSCGDLKLA
HHHHHHCCCCHHHHH		15.5127251275
236UbiquitinationYQVIVKNKMFSNAGI
HHHHHCCCCCCCCCE		35.29-
252PhosphorylationKMNMGNIYLKQRNYS
EHHHCCEEEEECCHH		16.3125884760
254UbiquitinationNMGNIYLKQRNYSKA
HHCCEEEEECCHHHH		30.18-
258PhosphorylationIYLKQRNYSKAIKFY
EEEEECCHHHHHHHH		17.46-
259PhosphorylationYLKQRNYSKAIKFYR
EEEECCHHHHHHHHH		21.11-
263UbiquitinationRNYSKAIKFYRMALD
CCHHHHHHHHHHHHH		41.00-
277UbiquitinationDQVPSVNKQMRIKIM
HCCCCCCHHHHHHHH		43.23-
351UbiquitinationPLEIDEDKYISPSDD
CEECCCCCCCCCCCC		42.30-
352PhosphorylationLEIDEDKYISPSDDP
EECCCCCCCCCCCCC		20.9627642862
369UbiquitinationNLVTEAIKNDHLRQM
CHHHHHHHHHHHHHH		64.47-
386UbiquitinationERKAMAEKYIMTSAK
HHHHHHHHHHHHHHH		30.45-
417PhosphorylationCVEVVKASQYVELAN
HHHHHHHHHHHHHHH		19.1427050516
430UbiquitinationANDLEINKAVTYLRQ
HHHHCHHHHHHHHHH		50.31-
438UbiquitinationAVTYLRQKDYNQAVE
HHHHHHHCCHHHHHH		56.60-
448AcetylationNQAVEILKVLEKKDS
HHHHHHHHHHHHCCH		50.8910565823
448UbiquitinationNQAVEILKVLEKKDS
HHHHHHHHHHHHCCH		50.89-
452AcetylationEILKVLEKKDSRVKS
HHHHHHHHCCHHHHH		58.6910565819
453AcetylationILKVLEKKDSRVKSA
HHHHHHHCCHHHHHH		52.1110565827
458UbiquitinationEKKDSRVKSAAATNL
HHCCHHHHHHHHHCH		33.01-
490 (in isoform 2)Ubiquitination-32.7121906983
499 (in isoform 1)Ubiquitination-48.5821906983
499UbiquitinationNPAALTNKGNTVFAN
CCHHHCCCCCEEECC		48.5821906983
502 (in isoform 2)Ubiquitination-26.1821906983
508 (in isoform 2)Ubiquitination-48.5021906983
509PhosphorylationTVFANGDYEKAAEFY
EEECCCCHHHHHHHH		22.2627642862
511UbiquitinationFANGDYEKAAEFYKE
ECCCCHHHHHHHHHH		46.8221906983
511 (in isoform 1)Ubiquitination-46.8221906983
517UbiquitinationEKAAEFYKEALRNDS
HHHHHHHHHHHHCCC		41.662190698
517 (in isoform 1)Ubiquitination-41.6621906983
619PhosphorylationSQAFQYYYESYRYFP
HHHHHHHHHHHCCCC		8.08-
622PhosphorylationFQYYYESYRYFPCNI
HHHHHHHHCCCCCCH		9.44-
681UbiquitinationRRSGNYQKALDTYKD
HHCCCHHHHHHHHHH		40.32-
687UbiquitinationQKALDTYKDTHRKFP
HHHHHHHHHHHHHCC		59.24-
713UbiquitinationLCTDLGLKDAQEYAR
HHHHCCCHHHHHHHH		49.58-
743PhosphorylationIKSGRDGSGGSRGKR
HHCCCCCCCCCCCCC		44.24-
746PhosphorylationGRDGSGGSRGKREGS
CCCCCCCCCCCCCCC		41.19-
753PhosphorylationSRGKREGSASGDSGQ
CCCCCCCCCCCCCCC		17.9525106551
755PhosphorylationGKREGSASGDSGQNY
CCCCCCCCCCCCCCC		44.8423090842
758PhosphorylationEGSASGDSGQNYSAS
CCCCCCCCCCCCCCC		45.8923090842
762PhosphorylationSGDSGQNYSASSKGE
CCCCCCCCCCCCCCH		9.5723090842
763PhosphorylationGDSGQNYSASSKGER
CCCCCCCCCCCCCHH		29.2623090842
765PhosphorylationSGQNYSASSKGERLS
CCCCCCCCCCCHHHH		27.0023090842
766PhosphorylationGQNYSASSKGERLSA
CCCCCCCCCCHHHHH		44.3823090842
796PhosphorylationSNKEIDASYVDPLGP
CCCCCCHHHCCCCCC		23.1828796482
797PhosphorylationNKEIDASYVDPLGPQ
CCCCCHHHCCCCCCC		15.5928796482
814AcetylationRPKTAAKKRIDEDDF
CCCCHHHHCCCCCCC		50.2766725591
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IFT88_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IFT88_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IFT88_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRC2A_HUMANPRRC2Aphysical
14667819
IFT80_HUMANIFT80physical
26344197
UBX10_HUMANUBXN10physical
26389662
TERA_HUMANVCPphysical
26389662
IF172_HUMANIFT172physical
27173435
IFT20_HUMANIFT20physical
27173435
IFT74_HUMANIFT74physical
27173435
IFT46_HUMANIFT46physical
27173435
TT30A_HUMANTTC30Aphysical
27173435
IFT27_HUMANIFT27physical
27173435
IFT57_HUMANIFT57physical
27173435
MIPT3_HUMANTRAF3IP1physical
27173435
CLUA1_HUMANCLUAP1physical
27173435
TT30B_HUMANTTC30Bphysical
27173435
IFT25_HUMANHSPB11physical
27173435
IFT56_HUMANTTC26physical
27173435
IFT22_HUMANIFT22physical
27173435
IFT52_HUMANIFT52physical
27173435
ICK_HUMANICKphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IFT88_HUMAN

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Related Literatures of Post-Translational Modification

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