dbPTM

PRC2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRC2A_HUMAN
UniProt AC	P48634
Protein Name	Protein PRRC2A
Gene Name	PRRC2A
Organism	Homo sapiens (Human).
Sequence Length	2157
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	May play a role in the regulation of pre-mRNA splicing..
Protein Sequence	MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAEEPGSRGDKEPGLPPPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	KGKDGKKYSSLNLFD CCCCCCEECCCCCEE	13.64	28796482
18	Phosphorylation	GKDGKKYSSLNLFDT CCCCCEECCCCCEEC	36.91	25159151
19	Phosphorylation	KDGKKYSSLNLFDTY CCCCEECCCCCEECC	20.42	25159151
25	Phosphorylation	SSLNLFDTYKGKSLE CCCCCEECCCCCEEE	21.57	29978859
26	Phosphorylation	SLNLFDTYKGKSLEI CCCCEECCCCCEEEE	21.42	29978859
27	Acetylation	LNLFDTYKGKSLEIQ CCCEECCCCCEEEEC	63.05	19608861
29	Acetylation	LFDTYKGKSLEIQKP CEECCCCCEEEECCC	47.95	26051181
30	Phosphorylation	FDTYKGKSLEIQKPA EECCCCCEEEECCCC	39.64	23312004
35	Acetylation	GKSLEIQKPAVAPRH CCEEEECCCCCCCCC	40.37	23954790
41	Methylation	QKPAVAPRHGLQSLG CCCCCCCCCCHHHHH	27.11	-
46	Phosphorylation	APRHGLQSLGKVAIA CCCCCHHHHHHHHHH	44.10	25159151
49	Acetylation	HGLQSLGKVAIARRM CCHHHHHHHHHHHCC	33.51	25953088
55	Methylation	GKVAIARRMPPPANL HHHHHHHCCCCCCCC	32.70	-
56	Sulfoxidation	KVAIARRMPPPANLP HHHHHHCCCCCCCCC	4.94	21406390
64	Phosphorylation	PPPANLPSLKAENKG CCCCCCCCHHCCCCC	45.74	24719451
77	Phosphorylation	KGNDPNVSLVPKDGT CCCCCCCEEECCCCC	30.23	28555341
108	Phosphorylation	STAQPPESQPLPASQ CCCCCCCCCCCCCCC	42.76	28555341
114	Phosphorylation	ESQPLPASQTPASNQ CCCCCCCCCCCCCCC	32.42	25159151
116	Phosphorylation	QPLPASQTPASNQPK CCCCCCCCCCCCCCC	20.51	21815630
119	Phosphorylation	PASQTPASNQPKRPP CCCCCCCCCCCCCCC	36.88	25159151
132	Phosphorylation	PPAAPENTPLVPSGV CCCCCCCCCCCCCCH	19.15	25159151
137	Phosphorylation	ENTPLVPSGVKSWAQ CCCCCCCCCHHHHHC	49.06	25159151
141	Phosphorylation	LVPSGVKSWAQASVT CCCCCHHHHHCCCCC	25.82	26434776
146	Phosphorylation	VKSWAQASVTHGAHG HHHHHCCCCCCCCCC	18.57	23401153
148	Phosphorylation	SWAQASVTHGAHGDG HHHCCCCCCCCCCCC	16.46	28857561
159	Phosphorylation	HGDGGRASSLLSRFS CCCCHHHHHHHHHHC	21.84	30266825
160	Phosphorylation	GDGGRASSLLSRFSR CCCHHHHHHHHHHCH	32.14	30266825
163	Phosphorylation	GRASSLLSRFSREEF HHHHHHHHHHCHHHC	36.25	30266825
166	Phosphorylation	SSLLSRFSREEFPTL HHHHHHHCHHHCCCH	37.36	23401153
172	Phosphorylation	FSREEFPTLQAAGDQ HCHHHCCCHHHHCCH	36.50	30266825
188	Phosphorylation	KAAKERESAEQSSGP HHHHHHHHHHHHCCC	43.24	23312004
192	Phosphorylation	ERESAEQSSGPGPSL HHHHHHHHCCCCCCC	28.86	23312004
193	Phosphorylation	RESAEQSSGPGPSLR HHHHHHHCCCCCCCC	49.02	27251275
198	Phosphorylation	QSSGPGPSLRPQNST HHCCCCCCCCCCCCC	42.81	30624053
204	Phosphorylation	PSLRPQNSTTWRDGG CCCCCCCCCCCCCCC	23.20	17287340
205	Phosphorylation	SLRPQNSTTWRDGGG CCCCCCCCCCCCCCC	37.62	23401153
206	Phosphorylation	LRPQNSTTWRDGGGR CCCCCCCCCCCCCCC	20.51	28857561
232	Methylation	LHHGHDPRGGLQPSG CCCCCCCCCCCCCCC	58.85	-
247	Methylation	PPQFPPYRGMMPPFM CCCCCCCCCCCCCCC	32.10	-
272	Asymmetric dimethylarginine	YGPQGPYRYPTPDGP CCCCCCCCCCCCCCC	33.80	-
272	Methylation	YGPQGPYRYPTPDGP CCCCCCCCCCCCCCC	33.80	24129315
281	Dimethylation	PTPDGPSRFPRVAGP CCCCCCCCCCCCCCC	49.04	-
281	Methylation	PTPDGPSRFPRVAGP CCCCCCCCCCCCCCC	49.04	-
284	Dimethylation	DGPSRFPRVAGPRGS CCCCCCCCCCCCCCC	28.36	-
284	Methylation	DGPSRFPRVAGPRGS CCCCCCCCCCCCCCC	28.36	-
289	Dimethylation	FPRVAGPRGSGPPMR CCCCCCCCCCCCCCC	51.49	-
289	Methylation	FPRVAGPRGSGPPMR CCCCCCCCCCCCCCC	51.49	-
296	Dimethylation	RGSGPPMRLVEPVGR CCCCCCCCCEECCCC	41.16	-
296	Methylation	RGSGPPMRLVEPVGR CCCCCCCCCEECCCC	41.16	24129315
305	Phosphorylation	VEPVGRPSILKEDNL EECCCCCHHCCCCCH	38.91	23186163
335	Phosphorylation	GAHEEVDYTEKLKFS CCCCCCCCHHHCCCC	23.21	-
342	Phosphorylation	YTEKLKFSDEEDGRD CHHHCCCCCCCCCCC	42.39	29255136
342 (in isoform 2)	Phosphorylation	-	42.39	18669648
350	Phosphorylation	DEEDGRDSDEEGAEG CCCCCCCCCCCCCCC	45.63	29255136
350 (in isoform 2)	Phosphorylation	-	45.63	18669648
361	Phosphorylation	GAEGHRDSQSASGEE CCCCCCCCCCCCCCC	26.45	22167270
363	Phosphorylation	EGHRDSQSASGEERP CCCCCCCCCCCCCCC	28.49	23401153
365	Phosphorylation	HRDSQSASGEERPPE CCCCCCCCCCCCCCC	52.57	22167270
380	Phosphorylation	ADGKKGNSPNSEPPT CCCCCCCCCCCCCCC	33.84	29255136
380 (in isoform 2)	Phosphorylation	-	33.84	18669648
383	Phosphorylation	KKGNSPNSEPPTPKT CCCCCCCCCCCCCCC	55.66	23927012
383 (in isoform 2)	Phosphorylation	-	55.66	18669648
387	Phosphorylation	SPNSEPPTPKTAWAE CCCCCCCCCCCCCCC	48.40	23927012
390	Phosphorylation	SEPPTPKTAWAETSR CCCCCCCCCCCCCCC	28.74	26552605
395	Phosphorylation	PKTAWAETSRPPETE CCCCCCCCCCCCCCC	23.45	28555341
396	Phosphorylation	KTAWAETSRPPETEP CCCCCCCCCCCCCCC	34.00	26552605
456	Phosphorylation	WRQRRKQSSSEISLA HHHHHHHCHHHHHHH	38.58	29255136
457	Phosphorylation	RQRRKQSSSEISLAV HHHHHHCHHHHHHHH	29.51	30266825
458	Phosphorylation	QRRKQSSSEISLAVE HHHHHCHHHHHHHHH	44.17	30266825
461	Phosphorylation	KQSSSEISLAVERAR HHCHHHHHHHHHHHH	13.26	23927012
486	S-palmitoylation	QEERRAACAEKLKRL HHHHHHHHHHHHHHH	4.98	29575903
489	2-Hydroxyisobutyrylation	RRAACAEKLKRLDEK HHHHHHHHHHHHHHH	40.56	-
489	Acetylation	RRAACAEKLKRLDEK HHHHHHHHHHHHHHH	40.56	25953088
502	Acetylation	EKFGAPDKRLKAEPA HHHCCCCHHCCCCCC	59.58	23749302
516	Phosphorylation	AAPPAAPSTPAPPPA CCCCCCCCCCCCCCC	42.15	29255136
517	Phosphorylation	APPAAPSTPAPPPAV CCCCCCCCCCCCCCC	23.55	29255136
595	Phosphorylation	PVEPQLPSKEGPEPP CCCCCCCCCCCCCCC	52.51	24719451
609	Phosphorylation	PEEVPPPTTPPVPKV CCCCCCCCCCCCCCC	58.68	29255136
610	Phosphorylation	EEVPPPTTPPVPKVE CCCCCCCCCCCCCCC	31.22	29255136
631	Phosphorylation	GPTRQPPSQGLGYPK CCCCCCCCCCCCCCH	43.49	28152594
636	Phosphorylation	PPSQGLGYPKYQKSL CCCCCCCCCHHHHCC	11.12	28152594
639	Phosphorylation	QGLGYPKYQKSLPPR CCCCCCHHHHCCCHH	19.37	20201521
642	Phosphorylation	GYPKYQKSLPPRFQR CCCHHHHCCCHHHHH	30.50	20201521
671	Phosphorylation	WQQHQQGSAPPTPVP HHHHHCCCCCCCCCC	33.01	25002506
675	Phosphorylation	QQGSAPPTPVPPSPP HCCCCCCCCCCCCCC	35.54	26074081
680	Phosphorylation	PPTPVPPSPPQPVTL CCCCCCCCCCCCCEE	43.04	26074081
686	Phosphorylation	PSPPQPVTLGAVPAP CCCCCCCEECCCCCC	26.59	26074081
722	Methylation	PPMNFDPRWMMIPPY CCCCCCCCCCCCCCC	35.45	-
729	Phosphorylation	RWMMIPPYVDPRLLQ CCCCCCCCCCHHHHC	16.48	27259358
738	Methylation	DPRLLQGRPPLDFYP CHHHHCCCCCCCCCC	19.39	-
759	Phosphorylation	GLVPRERSDSGGSSS CCCCCCCCCCCCCCC	31.23	23927012
761	Phosphorylation	VPRERSDSGGSSSEP CCCCCCCCCCCCCCC	46.42	19664994
764	Phosphorylation	ERSDSGGSSSEPFDR CCCCCCCCCCCCCHH	33.93	29255136
765	Phosphorylation	RSDSGGSSSEPFDRH CCCCCCCCCCCCHHH	41.83	29255136
766	Phosphorylation	SDSGGSSSEPFDRHA CCCCCCCCCCCHHHH	51.49	23927012
771	Methylation	SSSEPFDRHAPAMLR CCCCCCHHHHHHHHH	28.39	-
782	Phosphorylation	AMLRERGTPPVDPKL HHHHHCCCCCCCCCC	30.55	23401153
797	Phosphorylation	AWVGDVFTATPAEPR EECCCEEECCCCCCC	29.48	28176443
799	Phosphorylation	VGDVFTATPAEPRPL CCCEEECCCCCCCCC	21.70	26055452
807	Phosphorylation	PAEPRPLTSPLRQAA CCCCCCCCCHHHHHC	30.86	29255136
808	Phosphorylation	AEPRPLTSPLRQAAD CCCCCCCCHHHHHCC	29.62	29255136
823	Phosphorylation	EDDKGMRSETPPVPP CCCCCCCCCCCCCCC	36.61	29255136
825	Phosphorylation	DKGMRSETPPVPPPP CCCCCCCCCCCCCCC	33.85	29255136
834	Phosphorylation	PVPPPPPYLASYPGF CCCCCCCCCCCCCCC	22.22	23663014
837	Phosphorylation	PPPPYLASYPGFPEN CCCCCCCCCCCCCCC	29.30	23663014
838	Phosphorylation	PPPYLASYPGFPENG CCCCCCCCCCCCCCC	11.19	23663014
852	Phosphorylation	GAPGPPISRFPLEEP CCCCCCCCCCCCCCC	33.37	26074081
876 (in isoform 4)	Ubiquitination	-	3.88	21906983
878	Phosphorylation	DEVAKIQTPPPKKEP CCCCCCCCCCCCCCC	41.03	27794612
890	Phosphorylation	KEPPKEETAQLTGPE CCCCHHHHHHHCCCC	22.31	30576142
894	Phosphorylation	KEETAQLTGPEAGRK HHHHHHHCCCCCCCC	38.31	21815630
904	Methylation	EAGRKPARGVGSGGQ CCCCCCCCCCCCCCC	49.18	-
908	Phosphorylation	KPARGVGSGGQGPPP CCCCCCCCCCCCCCC	37.03	21815630
920	Phosphorylation	PPPPRRESRTETRWG CCCCCCCCCCCCCCC	42.57	23898821
922	Phosphorylation	PPRRESRTETRWGPR CCCCCCCCCCCCCCC	51.49	-
932	Phosphorylation	RWGPRPGSSRRGIPP CCCCCCCCCCCCCCC	24.29	26434776
933	Phosphorylation	WGPRPGSSRRGIPPE CCCCCCCCCCCCCCC	31.73	23403867
953	Acetylation	PRRAGPIKKPPPPTK CCCCCCCCCCCCCCC	63.46	26051181
975	Phosphorylation	PLEQGDETPKPPKPD CCCCCCCCCCCCCCC	41.16	25159151
990	Acetylation	PLKITKGKLGGPKET CCCCCCCCCCCCCCC	45.58	25953088
997	Phosphorylation	KLGGPKETPPNGNLS CCCCCCCCCCCCCCC	50.61	26055452
1004	Phosphorylation	TPPNGNLSPAPRLRR CCCCCCCCCCCCCCC	24.02	29255136
1013	Phosphorylation	APRLRRDYSYERVGP CCCCCCCCCCCCCCC	16.02	23403867
1014	Phosphorylation	PRLRRDYSYERVGPT CCCCCCCCCCCCCCC	25.47	23401153
1015	Phosphorylation	RLRRDYSYERVGPTS CCCCCCCCCCCCCCC	11.09	23403867
1022	Phosphorylation	YERVGPTSCRGRGRG CCCCCCCCCCCCCCC	12.63	23828894
1024	Methylation	RVGPTSCRGRGRGEY CCCCCCCCCCCCCCC	37.30	-
1026	Methylation	GPTSCRGRGRGEYFA CCCCCCCCCCCCCCC	16.57	-
1028	Methylation	TSCRGRGRGEYFARG CCCCCCCCCCCCCCC	33.15	-
1031	Phosphorylation	RGRGRGEYFARGRGF CCCCCCCCCCCCCCC	12.83	18083107
1034	Methylation	GRGEYFARGRGFRGT CCCCCCCCCCCCCCC	25.99	-
1036	Methylation	GEYFARGRGFRGTYG CCCCCCCCCCCCCCC	35.21	-
1039	Methylation	FARGRGFRGTYGGRG CCCCCCCCCCCCCCC	39.09	-
1056	Phosphorylation	ARSREFRSYREFRGD CCCHHCCCHHHHCCC	33.59	23186163
1057	Phosphorylation	RSREFRSYREFRGDD CCHHCCCHHHHCCCC	15.20	23186163
1066	Methylation	EFRGDDGRGGGTGGP HHCCCCCCCCCCCCC	47.80	-
1070	Phosphorylation	DDGRGGGTGGPNHPP CCCCCCCCCCCCCCC	42.09	28555341
1080	Methylation	PNHPPAPRGRTASET CCCCCCCCCCCCHHC	49.70	-
1080 (in isoform 2)	Phosphorylation	-	49.70	20068231
1082	Methylation	HPPAPRGRTASETRS CCCCCCCCCCHHCCC	28.53	-
1083	Phosphorylation	PPAPRGRTASETRSE CCCCCCCCCHHCCCC	37.04	23927012
1084 (in isoform 2)	Phosphorylation	-	12.19	20068231
1085	Phosphorylation	APRGRTASETRSEGS CCCCCCCHHCCCCCC	38.60	20201521
1086 (in isoform 2)	Phosphorylation	-	45.86	20068231
1087	Phosphorylation	RGRTASETRSEGSEY CCCCCHHCCCCCCCC	36.68	25159151
1089	Phosphorylation	RTASETRSEGSEYEE CCCHHCCCCCCCCCC	54.45	19664994
1090 (in isoform 2)	Phosphorylation	-	64.55	20068231
1092	Phosphorylation	SETRSEGSEYEEIPK HHCCCCCCCCCCCCH	32.71	19664994
1092 (in isoform 3)	Phosphorylation	-	32.71	20068231
1094	Phosphorylation	TRSEGSEYEEIPKRR CCCCCCCCCCCCHHH	22.13	22167270
1096 (in isoform 3)	Phosphorylation	-	64.78	20068231
1098 (in isoform 3)	Phosphorylation	-	27.64	20068231
1102 (in isoform 3)	Phosphorylation	-	34.28	20068231
1106	Phosphorylation	KRRRQRGSETGSETH HHHHHCCCCCCCCCC	33.89	29255136
1108	Phosphorylation	RRQRGSETGSETHES HHHCCCCCCCCCCHH	47.94	29255136
1108 (in isoform 2)	Phosphorylation	-	47.94	29083192
1110	Phosphorylation	QRGSETGSETHESDL HCCCCCCCCCCHHHC	46.90	29255136
1112	Phosphorylation	GSETGSETHESDLAP CCCCCCCCCHHHCCC	32.42	29255136
1115	Phosphorylation	TGSETHESDLAPSDK CCCCCCHHHCCCCCC	30.25	29255136
1120	Phosphorylation	HESDLAPSDKEAPTP CHHHCCCCCCCCCCC	56.56	23401153
1120 (in isoform 3)	Phosphorylation	-	56.56	29083192
1126	Phosphorylation	PSDKEAPTPKEGTLT CCCCCCCCCCCCCEE	54.78	30266825
1131	Phosphorylation	APTPKEGTLTQVPLA CCCCCCCCEEEECCC	27.94	23403867
1133	Phosphorylation	TPKEGTLTQVPLAPP CCCCCCEEEECCCCC	27.62	23403867
1147	Phosphorylation	PPPGAPPSPAPARFT CCCCCCCCCCCCCEE	32.41	29255136
1152	Methylation	PPSPAPARFTARGGR CCCCCCCCEEECCCE	28.52	-
1156	Methylation	APARFTARGGRVFTP CCCCEEECCCEEECC	45.07	-
1159	Methylation	RFTARGGRVFTPRGV CEEECCCEEECCCCC	24.17	-
1162	Phosphorylation	ARGGRVFTPRGVPSR ECCCEEECCCCCCCC	14.82	24719451
1164	Methylation	GGRVFTPRGVPSRRG CCEEECCCCCCCCCC	56.54	-
1168	Phosphorylation	FTPRGVPSRRGRGGG ECCCCCCCCCCCCCC	32.00	28258704
1169	Methylation	TPRGVPSRRGRGGGR CCCCCCCCCCCCCCC	38.72	-
1186	Phosphorylation	PQVCPGWSPPAKSLA CCCCCCCCCCHHHCC	27.24	28111955
1196	Acetylation	AKSLAPKKPPTGPLP HHHCCCCCCCCCCCC	55.99	19608861
1219	Phosphorylation	KLIPGPLSPVARGGS CCCCCCCCCCCCCCC	22.06	29255136
1223	Methylation	GPLSPVARGGSNGGS CCCCCCCCCCCCCCC	50.68	-
1226	Phosphorylation	SPVARGGSNGGSNVG CCCCCCCCCCCCCCC	34.82	26074081
1230	Phosphorylation	RGGSNGGSNVGMEDG CCCCCCCCCCCCCCC	29.73	26074081
1276	Phosphorylation	RGSEGKPSLTLPASA CCCCCCCCCCCCCCC	37.16	24719451
1278	Phosphorylation	SEGKPSLTLPASAPG CCCCCCCCCCCCCCC	34.72	28348404
1291	Phosphorylation	PGPEEALTTVTVAPA CCHHHHCEEEEEECC	26.69	26074081
1292	Phosphorylation	GPEEALTTVTVAPAP CHHHHCEEEEEECCC	18.28	26074081
1294	Phosphorylation	EEALTTVTVAPAPRR HHHCEEEEEECCCCC	14.62	26074081
1306	Phosphorylation	PRRAAAKSPDLSNQN CCCHHHHCCCCCCCC	20.94	30266825
1310	Phosphorylation	AAKSPDLSNQNSDQA HHHCCCCCCCCHHHH	43.69	30266825
1314	Phosphorylation	PDLSNQNSDQANEEW CCCCCCCHHHHHHHH	22.72	30266825
1323	Phosphorylation	QANEEWETASESSDF HHHHHHHHHHHHCCC	36.23	30266825
1325	Phosphorylation	NEEWETASESSDFTS HHHHHHHHHHCCCCC	45.49	23927012
1327	Phosphorylation	EWETASESSDFTSER HHHHHHHHCCCCCCC	32.48	30576142
1328	Phosphorylation	WETASESSDFTSERR HHHHHHHCCCCCCCC	32.46	20363803
1331	Phosphorylation	ASESSDFTSERRGDK HHHHCCCCCCCCCCC	34.37	23090842
1332	Phosphorylation	SESSDFTSERRGDKE HHHCCCCCCCCCCCC	29.15	27251275
1347	Phosphorylation	APPPVLLTPKAVGTP CCCCEEECCCCCCCC	20.69	29255136
1353	Phosphorylation	LTPKAVGTPGGGGGG ECCCCCCCCCCCCCC	16.50	25159151
1366	Phosphorylation	GGAVPGISAMSRGDL CCCCCCHHHCCCCCH	24.67	29396449
1368	Sulfoxidation	AVPGISAMSRGDLSQ CCCCHHHCCCCCHHH	1.93	21406390
1369	Phosphorylation	VPGISAMSRGDLSQR CCCHHHCCCCCHHHH	32.59	29396449
1370	Methylation	PGISAMSRGDLSQRA CCHHHCCCCCHHHHH	29.56	-
1374	Phosphorylation	AMSRGDLSQRAKDLS HCCCCCHHHHHHHHH	23.51	23909892
1376	Methylation	SRGDLSQRAKDLSKR CCCCHHHHHHHHHHH	39.98	-
1378	Methylation	GDLSQRAKDLSKRSF CCHHHHHHHHHHHHH	62.48	-
1381	Phosphorylation	SQRAKDLSKRSFSSQ HHHHHHHHHHHHHCC	35.84	23909892
1383	Methylation	RAKDLSKRSFSSQRP HHHHHHHHHHHCCCC	39.29	-
1384	Phosphorylation	AKDLSKRSFSSQRPG HHHHHHHHHHCCCCC	32.96	23401153
1386	Phosphorylation	DLSKRSFSSQRPGME HHHHHHHHCCCCCCC	27.14	23401153
1387	Phosphorylation	LSKRSFSSQRPGMER HHHHHHHCCCCCCCC	28.35	26846344
1398	Methylation	GMERQNRRPGPGGKA CCCCCCCCCCCCCCC	48.34	-
1407	Phosphorylation	GPGGKAGSSGSSSGG CCCCCCCCCCCCCCC	36.06	22210691
1408	Phosphorylation	PGGKAGSSGSSSGGG CCCCCCCCCCCCCCC	41.60	30177828
1410	Phosphorylation	GKAGSSGSSSGGGGG CCCCCCCCCCCCCCC	24.23	22210691
1411	Phosphorylation	KAGSSGSSSGGGGGG CCCCCCCCCCCCCCC	36.21	30177828
1412	Phosphorylation	AGSSGSSSGGGGGGP CCCCCCCCCCCCCCC	43.06	22210691
1427	Methylation	GGRTGPGRGDKRSWP CCCCCCCCCCCCCCC	53.95	-
1432	Phosphorylation	PGRGDKRSWPSPKNR CCCCCCCCCCCCCCC	49.43	23403867
1432 (in isoform 4)	Ubiquitination	-	49.43	21906983
1435	Phosphorylation	GDKRSWPSPKNRSRP CCCCCCCCCCCCCCC	42.10	22617229
1439 (in isoform 4)	Ubiquitination	-	39.92	21906983
1485	Phosphorylation	QALAQLSSRQGSVTA HHHHHHHHCCCCCCC	36.90	28555341
1487 (in isoform 2)	Ubiquitination	-	50.92	21906983
1489	Phosphorylation	QLSSRQGSVTAPGGH HHHHCCCCCCCCCCC	14.14	23401153
1491	Phosphorylation	SSRQGSVTAPGGHPR HHCCCCCCCCCCCCC	28.91	28555341
1499 (in isoform 3)	Ubiquitination	-	45.15	21906983
1500	Ubiquitination	PGGHPRHKPGLPQAP CCCCCCCCCCCCCCC	41.90	-
1500 (in isoform 1)	Ubiquitination	-	41.90	21906983
1518	Phosphorylation	SPRPPTRYEPQRVNS CCCCCCCCCCCCCCC	34.14	-
1525	Phosphorylation	YEPQRVNSGLSSDPH CCCCCCCCCCCCCCC	37.95	29978859
1528	Phosphorylation	QRVNSGLSSDPHFEE CCCCCCCCCCCCCCC	35.90	29978859
1529	Phosphorylation	RVNSGLSSDPHFEEP CCCCCCCCCCCCCCC	61.27	29978859
1554	Phosphorylation	PRDSAGVSPFPPKRR CCCCCCCCCCCCCCC	21.65	28985074
1607	Phosphorylation	DTGTEALTPHIWNRL CCCCHHCCHHHHHHH	21.62	27050516
1619	O-linked_Glycosylation	NRLHTATSRKSYRPS HHHHHHCCCCCCCCC	34.94	23301498
1670	Phosphorylation	SGPCSQRSSPDGGLK CCCCCCCCCCCCCCC	38.29	29396449
1671	Phosphorylation	GPCSQRSSPDGGLKG CCCCCCCCCCCCCCC	29.24	26657352
1686	Dimethylation	AAEGPPKRPGGSSPL CCCCCCCCCCCCCCC	40.65	-
1690	Phosphorylation	PPKRPGGSSPLNAVP CCCCCCCCCCCCCCC	34.40	23401153
1691	Phosphorylation	PKRPGGSSPLNAVPC CCCCCCCCCCCCCCC	36.36	30266825
1704	Phosphorylation	PCEGPPGSEPPRRPP CCCCCCCCCCCCCCC	53.34	23927012
1708	Dimethylation	PPGSEPPRRPPPAPH CCCCCCCCCCCCCCC	74.57	-
1735	Phosphorylation	LPPGPIGTERSQRTD CCCCCCCCCCCCCCC	29.01	24719451
1743	Methylation	ERSQRTDRGTEPGPI CCCCCCCCCCCCCCC	54.01	-
1764	Phosphorylation	GPPVQFGTSDKDSDL CCCCCCCCCCCCCCC	34.73	20068231
1765	Phosphorylation	PPVQFGTSDKDSDLR CCCCCCCCCCCCCCE	42.94	20068231
1772	Methylation	SDKDSDLRLVVGDSL CCCCCCCEEEECCCH	30.35	-
1778	Phosphorylation	LRLVVGDSLKAEKEL CEEEECCCHHHHHHH	26.32	20068231
1786	O-linked_Glycosylation	LKAEKELTASVTEAI HHHHHHHCEEHHEEE	20.27	23301498
1786	Phosphorylation	LKAEKELTASVTEAI HHHHHHHCEEHHEEE	20.27	23186163
1788	Phosphorylation	AEKELTASVTEAIPV HHHHHCEEHHEEECC	25.08	29978859
1790	O-linked_Glycosylation	KELTASVTEAIPVSR HHHCEEHHEEECCCC	19.73	23301498
1790	Phosphorylation	KELTASVTEAIPVSR HHHCEEHHEEECCCC	19.73	23186163
1796	O-linked_Glycosylation	VTEAIPVSRDWELLP HHEEECCCCCHHHCC	21.11	23301498
1814	Ubiquitination	ASAEPQSKNLDSGHC HCCCCCCCCCCCCCC	57.17	-
1833	Phosphorylation	SSSGQRLYPEVFYGS CCCCCCCCCEEECCC	10.27	30576142
1838	Phosphorylation	RLYPEVFYGSAGPSS CCCCEEECCCCCCCH	18.49	30576142
1840	Phosphorylation	YPEVFYGSAGPSSSQ CCEEECCCCCCCHHH	20.76	30576142
1844	Phosphorylation	FYGSAGPSSSQISGG ECCCCCCCHHHCCCC	41.52	27251275
1845	Phosphorylation	YGSAGPSSSQISGGA CCCCCCCHHHCCCCC	29.42	27251275
1846	Phosphorylation	GSAGPSSSQISGGAM CCCCCCHHHCCCCCC	35.55	27251275
1855	Phosphorylation	ISGGAMDSQLHPNSG CCCCCCCCCCCCCCC	22.89	27273156
1861	Phosphorylation	DSQLHPNSGGFRPGT CCCCCCCCCCCCCCC	44.75	27251275
1865	Methylation	HPNSGGFRPGTPSLH CCCCCCCCCCCCCCC	31.82	-
1868	Phosphorylation	SGGFRPGTPSLHPYR CCCCCCCCCCCCCCC	16.64	27273156
1874	Phosphorylation	GTPSLHPYRSQPLYL CCCCCCCCCCCCCCC	16.49	-
1875	Methylation	TPSLHPYRSQPLYLP CCCCCCCCCCCCCCC	33.01	-
2036	Phosphorylation	PATRVLPSPARPFPA CCCCCCCCCCCCCCC	27.34	22199227
2043 (in isoform 2)	Ubiquitination	-	20.12	21906983
2044	Phosphorylation	PARPFPASLGRAELH CCCCCCCCCCCCCCC	31.43	28555341
2050 (in isoform 2)	Ubiquitination	-	5.59	21906983
2055 (in isoform 3)	Ubiquitination	-	9.69	21906983
2056	Ubiquitination	ELHPVELKPFQDYQK CCCCCCCCCCCHHHH	30.22	21906983
2056 (in isoform 1)	Ubiquitination	-	30.22	21906983
2061	Phosphorylation	ELKPFQDYQKLSSNL CCCCCCHHHHHHHHC	9.21	27642862
2062 (in isoform 3)	Ubiquitination	-	48.80	21906983
2063	Ubiquitination	KPFQDYQKLSSNLGG CCCCHHHHHHHHCCC	44.07	21906983
2063 (in isoform 1)	Ubiquitination	-	44.07	21906983
2065	Phosphorylation	FQDYQKLSSNLGGPG CCHHHHHHHHCCCCC	24.98	23403867
2066	Phosphorylation	QDYQKLSSNLGGPGS CHHHHHHHHCCCCCC	46.65	23403867
2073	Phosphorylation	SNLGGPGSSRTPPTG HHCCCCCCCCCCCCC	21.56	25159151
2074	Phosphorylation	NLGGPGSSRTPPTGR HCCCCCCCCCCCCCC	46.20	28258704
2076	Phosphorylation	GGPGSSRTPPTGRSF CCCCCCCCCCCCCCC	35.25	23403867
2079	Phosphorylation	GSSRTPPTGRSFSGL CCCCCCCCCCCCCCH	46.56	23403867
2082	Phosphorylation	RTPPTGRSFSGLNSR CCCCCCCCCCCHHHH	25.72	23917254
2084	Phosphorylation	PPTGRSFSGLNSRLK CCCCCCCCCHHHHCC	43.55	-
2088	Phosphorylation	RSFSGLNSRLKATPS CCCCCHHHHCCCCCC	43.99	20860994
2089	Methylation	SFSGLNSRLKATPST CCCCHHHHCCCCCCC	38.85	-
2091	Ubiquitination	SGLNSRLKATPSTYS CCHHHHCCCCCCCCC	49.45	-
2093	Phosphorylation	LNSRLKATPSTYSGV HHHHCCCCCCCCCCC	19.04	21815630
2095	Phosphorylation	SRLKATPSTYSGVFR HHCCCCCCCCCCCEE	35.31	23312004
2098	Phosphorylation	KATPSTYSGVFRTQR CCCCCCCCCCEECCC	28.68	28555341
2109	Phosphorylation	RTQRVDLYQQASPPD ECCCEEHHHHCCCCC	8.30	28796482
2113	Phosphorylation	VDLYQQASPPDALRW EEHHHHCCCCCHHHC	32.40	30266825
2128	Phosphorylation	IPKPWERTGPPPREG CCCCHHHCCCCCCCC	42.39	20068231
2137	Phosphorylation	PPPREGPSRRAEEPG CCCCCCCCCCCCCCC	45.30	24670416

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1353	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRC2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRC2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_HUMAN	GRB2	physical	14667819
FIBA_HUMAN	FGA	physical	14667819
MD2L2_HUMAN	MAD2L2	physical	14667819
P4HA2_HUMAN	P4HA2	physical	14667819
CCR10_HUMAN	CCR10	physical	14667819
GANAB_HUMAN	GANAB	physical	14667819
PSA3_HUMAN	PSMA3	physical	14667819
MA2C1_HUMAN	MAN2C1	physical	14667819
SSRG_HUMAN	SSR3	physical	14667819
DDX20_HUMAN	DDX20	physical	14667819
CPSF1_HUMAN	CPSF1	physical	14667819
ANM2_HUMAN	PRMT2	physical	14667819
SYQ_HUMAN	QARS	physical	14667819
EIF3E_HUMAN	EIF3E	physical	14667819
MIC60_HUMAN	IMMT	physical	14667819
IFT88_HUMAN	IFT88	physical	14667819
UBP2L_HUMAN	UBAP2L	physical	14667819
C1QBP_HUMAN	C1QBP	physical	14667819
ROA1_HUMAN	HNRNPA1	physical	14667819
HNRPM_HUMAN	HNRNPM	physical	14667819
EWS_HUMAN	EWSR1	physical	21988832
GRB2_HUMAN	GRB2	physical	21988832
GORS2_HUMAN	GORASP2	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRC2A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27 AND LYS-1196, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-456; THR-610;SER-761; SER-1089 AND SER-1147, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-610; SER-1147 ANDSER-1219, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-380;SER-383; SER-456; THR-610; SER-759; SER-761; SER-764; SER-766;THR-997; SER-1004; SER-1014; SER-1085; THR-1087; SER-1089; SER-1092;TYR-1094; SER-1147; SER-1219; SER-1306 AND THR-1347, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609 AND SER-1219, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-204; SER-342;SER-350; SER-456; THR-517; SER-761 AND SER-764, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-1089;SER-1092 AND SER-1219, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1014, AND MASSSPECTROMETRY.	16083285 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-761; THR-610AND SER-1219, AND MASS SPECTROMETRY.	15302935 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1347, AND MASSSPECTROMETRY.	16964243 [Abstract]