ANM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANM2_HUMAN
• UniProt AC: P55345
• Protein Name: Protein arginine N-methyltransferase 2
• Gene Name: PRMT2
• Organism: Homo sapiens (Human).
• Sequence Length: 433
• Subcellular Localization: Isoform 1: Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; Isoform PRMT2Alpha: Nucleus. Excluded from nucleolus.; Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus.; I
• Protein Description: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation..
• Protein Sequence: MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSLQEGQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVALSWAVTSRQDPTSQKVGEKVFPIWR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	EFVAIADYAATDETQ HHEEEEEEECCCHHH	6.79	22817900
53	Methylation	ETQLSFLRGEKILIL HHHHHHHCCCEEEEE	49.57	58854897
56	Ubiquitination	LSFLRGEKILILRQT HHHHCCCEEEEEEEC	45.71	-
61	Asymmetric dimethylarginine	GEKILILRQTTADWW CCEEEEEEECCCCCC	25.46	-
61	Methylation	GEKILILRQTTADWW CCEEEEEEECCCCCC	25.46	24129315
72	Asymmetric dimethylarginine	ADWWWGERAGCCGYI CCCCCCCCCCCCCEE	32.13	-
72	Methylation	ADWWWGERAGCCGYI CCCCCCCCCCCCCEE	32.13	24129315
86	Ubiquitination	IPANHVGKHVDEYDP EEHHHCCCCCCCCCC	39.09	-
124	Ubiquitination	ADQPRTTKYHSVILQ CCCCCCCCEEEEEEC	40.11	-
125	Phosphorylation	DQPRTTKYHSVILQN CCCCCCCEEEEEECC	9.38	17322306
127	Phosphorylation	PRTTKYHSVILQNKE CCCCCEEEEEECCCC	14.04	28857561
133	Ubiquitination	HSVILQNKESLTDKV EEEEECCCCCCCCCE	35.40	-
222	Ubiquitination	TCLLFEFMIESILYA HHHHHHHHHHHHHHH	2.33	-
277	Ubiquitination	EFNLSALKSLAVKEF HCCHHHHHHHHHHHH	43.04	-
286	Phosphorylation	LAVKEFFSKPKYNHI HHHHHHHCCCCCCCC	54.06	24719451
406	Phosphorylation	PVWRRHMSVALSWAV CCHHHHHHHHHHHHH	9.71	24043423
410	Phosphorylation	RHMSVALSWAVTSRQ HHHHHHHHHHHHCCC	11.85	24043423
414	Phosphorylation	VALSWAVTSRQDPTS HHHHHHHHCCCCCCC	15.50	24043423
415	Phosphorylation	ALSWAVTSRQDPTSQ HHHHHHHCCCCCCCC	22.73	24043423
427	Ubiquitination	TSQKVGEKVFPIWR- CCCCCCCEEECCCC-	43.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DMRTB_HUMAN	DMRTB1	physical	16189514
CPSF7_HUMAN	CPSF7	physical	16189514
HNRL1_HUMAN	HNRNPUL1	physical	11513728
ORF73_HHV8P	HHV8GK18_gp81	physical	22179613
ROA1_HUMAN	HNRNPA1	physical	19101556
RB_HUMAN	RB1	physical	16616919
PSB3_HUMAN	PSMB3	physical	21988832
UBB_HUMAN	UBB	physical	26186194
SALL2_HUMAN	SALL2	physical	26186194
GET4_HUMAN	GET4	physical	26186194
SHAN3_HUMAN	SHANK3	physical	26186194
HD_HUMAN	HTT	physical	26186194
TAB1_HUMAN	TAB1	physical	26186194
KANK2_HUMAN	KANK2	physical	26186194
LRFN1_HUMAN	LRFN1	physical	26186194
PKHH3_HUMAN	PLEKHH3	physical	26186194
P121A_HUMAN	POM121	physical	26186194
SF01_HUMAN	SF1	physical	26186194
LMBL3_HUMAN	L3MBTL3	physical	26186194
TIGD5_HUMAN	TIGD5	physical	26186194
KSR1_HUMAN	KSR1	physical	26186194
KRBA1_HUMAN	KRBA1	physical	26186194
RBPMS_HUMAN	RBPMS	physical	26186194
PPM1E_HUMAN	PPM1E	physical	26186194
ANTR1_HUMAN	ANTXR1	physical	26186194
TPC2A_HUMAN	TRAPPC2	physical	26186194
TPC2B_HUMAN	TRAPPC2	physical	26186194
SET1B_HUMAN	SETD1B	physical	26186194
SET1A_HUMAN	SETD1A	physical	26186194
P85A_HUMAN	PIK3R1	physical	26186194
FHOD1_HUMAN	FHOD1	physical	26186194
CXXC1_HUMAN	CXXC1	physical	26186194
ERF_HUMAN	ERF	physical	26186194
TTC28_HUMAN	TTC28	physical	26186194
SETD5_HUMAN	SETD5	physical	26186194
SAMD1_HUMAN	SAMD1	physical	26186194
VCIP1_HUMAN	VCPIP1	physical	26186194
CO039_HUMAN	C15orf39	physical	26186194
M3K7_HUMAN	MAP3K7	physical	26186194
LMBL3_HUMAN	L3MBTL3	physical	28514442
SHAN3_HUMAN	SHANK3	physical	28514442
HD_HUMAN	HTT	physical	28514442
SAMD1_HUMAN	SAMD1	physical	28514442
KSR1_HUMAN	KSR1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
CXXC1_HUMAN	CXXC1	physical	28514442
KRBA1_HUMAN	KRBA1	physical	28514442
ERF_HUMAN	ERF	physical	28514442
SET1B_HUMAN	SETD1B	physical	28514442
FHOD1_HUMAN	FHOD1	physical	28514442
SET1A_HUMAN	SETD1A	physical	28514442
ANTR1_HUMAN	ANTXR1	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
SETD5_HUMAN	SETD5	physical	28514442
VCIP1_HUMAN	VCPIP1	physical	28514442
PPM1E_HUMAN	PPM1E	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
P121A_HUMAN	POM121	physical	28514442
LRFN1_HUMAN	LRFN1	physical	28514442
UBR5_HUMAN	UBR5	physical	28514442
P85B_HUMAN	PIK3R2	physical	28514442
SALL2_HUMAN	SALL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.