PKHH3_HUMAN - dbPTM
PKHH3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHH3_HUMAN
UniProt AC Q7Z736
Protein Name Pleckstrin homology domain-containing family H member 3
Gene Name PLEKHH3
Organism Homo sapiens (Human).
Sequence Length 793
Subcellular Localization
Protein Description
Protein Sequence MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVTLTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLQRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTLALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDEPQGQSGCLGQLQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12S-palmitoylationGGLWWLLCCRRGFTL
CCHHHHHHCCCCCEE		1.2629575903
13S-palmitoylationGLWWLLCCRRGFTLL
CHHHHHHCCCCCEEE		3.1629575903
24PhosphorylationFTLLHRDYGDGELSG
CEEEEECCCCCCCCC		19.6427732954
30PhosphorylationDYGDGELSGDGDEDE
CCCCCCCCCCCCCCC		30.4530175587
48PhosphorylationTFELRTPSPAGGGRG
CEEECCCCCCCCCCC		27.1127732954
60PhosphorylationGRGPLEVTLTQPVRS
CCCCEEEEECCCCCC		18.0828555341
76PhosphorylationPVSNRLQSWEETWSL
CCCCCCCCHHHHHHC		40.8428176443
80PhosphorylationRLQSWEETWSLIPEK
CCCCHHHHHHCCCCC		14.6128176443
82PhosphorylationQSWEETWSLIPEKGL
CCHHHHHHCCCCCCC		24.6828176443
87 (in isoform 2)Ubiquitination-61.4621906983
87 (in isoform 3)Ubiquitination-61.4621906983
87 (in isoform 1)Ubiquitination-61.4621906983
87 (in isoform 4)Ubiquitination-61.4621906983
87UbiquitinationTWSLIPEKGLPEDDP
HHHCCCCCCCCCCCC		61.4621906983
137 (in isoform 1)Ubiquitination-51.8821906983
137 (in isoform 2)Ubiquitination-51.8821906983
137UbiquitinationDQFSSSGKGARRLGS
HHHHCCCCHHHHHHH		51.8821906983
137 (in isoform 3)Ubiquitination-51.8821906983
137 (in isoform 4)Ubiquitination-51.8821906983
144PhosphorylationKGARRLGSLVLTSLC
CHHHHHHHHHHHHHC		21.64-
148PhosphorylationRLGSLVLTSLCSVTG
HHHHHHHHHHCCCCC		16.51-
163PhosphorylationPERRRKETGLWSVTV
CCHHHCCCCCEEEEE		40.38-
201UbiquitinationLREVIASKAPLETPT
HHHHHHHCCCCCCHH		45.0321906983
201 (in isoform 1)Ubiquitination-45.0321906983
201 (in isoform 2)Ubiquitination-45.0321906983
201 (in isoform 3)Ubiquitination-45.0321906983
201 (in isoform 4)Ubiquitination-45.0321906983
310 (in isoform 2)Ubiquitination-63.8021906983
310 (in isoform 1)Ubiquitination-63.8021906983
310 (in isoform 3)Ubiquitination-63.8021906983
310 (in isoform 4)Ubiquitination-63.8021906983
310UbiquitinationELFLQLAKQTSGPAG
HHHHHHHHHCCCCCC		63.8021906983
449PhosphorylationSRNAFALYEQRGAQE
HCCCHHHHHHCCHHH		13.4427642862
506PhosphorylationPLHPEGLSPDGHELP
CCCCCCCCCCCCCCC		31.6224719451
534PhosphorylationRPPPPDDTLRALAAL
CCCCCHHHHHHHHHH		26.06-
545PhosphorylationLAALRLQSLQRDFSP
HHHHHHHHHCCCCCC		30.94-
553MethylationLQRDFSPRVPLPRLD
HCCCCCCCCCCCCHH		41.3081462407
593PhosphorylationLLAGALWSPGLAKRR
HHHHHHCCHHHHHHH		15.2228188228
612PhosphorylationRRGGAGRTAGSIARE
HCCCCCCCHHHHHCC		34.1628102081
615PhosphorylationGAGRTAGSIAREGGG
CCCCCHHHHHCCCCC		15.6022617229
632 (in isoform 2)Ubiquitination-33.0621906983
635UbiquitinationAAVLGGWKRLRGMGR
HHHHCCHHHHCCCCH		44.842190698
635 (in isoform 1)Ubiquitination-44.8421906983
635 (in isoform 3)Ubiquitination-44.8421906983
638MethylationLGGWKRLRGMGRAEA
HCCHHHHCCCCHHHH		36.7724129315
642MethylationKRLRGMGRAEAMAAY
HHHCCCCHHHHHHHH		21.9924129315
664PhosphorylationPGFGAARYDVLELST
CCCCCHHCEEEECCC		12.9927642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHH3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHH3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHH3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PKHH3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHH3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY.

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