PPM1E_HUMAN - dbPTM
PPM1E_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPM1E_HUMAN
UniProt AC Q8WY54
Protein Name Protein phosphatase 1E
Gene Name PPM1E
Organism Homo sapiens (Human).
Sequence Length 755
Subcellular Localization Nucleus . Cytoplasm . A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus.
Protein Description Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity)..
Protein Sequence MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPVEMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTGSGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
169PhosphorylationAAALARATSDEVLQS
HHHHHHHCCHHHHHH		3.0427251275
178PhosphorylationDEVLQSDLSAHYIPK
HHHHHHHHHHCCCCC		31.0228348404
179PhosphorylationEVLQSDLSAHYIPKE
HHHHHHHHHCCCCCC		30.6828348404
182PhosphorylationQSDLSAHYIPKETDG
HHHHHHCCCCCCCCC		7.6627251275
185PhosphorylationLSAHYIPKETDGTEG
HHHCCCCCCCCCCCC		36.0427251275
188PhosphorylationHYIPKETDGTEGTVE
CCCCCCCCCCCCEEE		20.2827251275
191PhosphorylationPKETDGTEGTVEIET
CCCCCCCCCEEEEEH		20.7327251275
202PhosphorylationEIETVKLARSVFSKL
EEEHHHHHHHHHHHH		14.5624275569
208UbiquitinationLARSVFSKLHEICCS
HHHHHHHHHHHHHHH		2.8729967540
216PhosphorylationLHEICCSWVKDFPLR
HHHHHHHHHHCCCCC		31.9522210691
322PhosphorylationERFVQKAARESLRCG
HHHHHHHHHHHHCCC		28.0824905233
407PhosphorylationSRAIGDAEHKPYICG
HHHCCCCCCCCEEEC		21.5324719451
409PhosphorylationAIGDAEHKPYICGDA
HCCCCCCCCEEECCC		16.78-
510PhosphorylationWTENSFQGGQEDGGD
CCCCCCCCCCCCCCC		34.10-
513PhosphorylationNSFQGGQEDGGDDKE
CCCCCCCCCCCCCCC		30.22-
516PhosphorylationQGGQEDGGDDKENHG
CCCCCCCCCCCCCCC		16.83-
535PhosphorylationPWPQHQCSAPADLGY
CCCCCCCCCCCCCCC		58.1324719451
544PhosphorylationPADLGYDGRVDSFTD
CCCCCCCCCCCCCCC		30.6222912867
548PhosphorylationGYDGRVDSFTDRTSL
CCCCCCCCCCCCCCC		39.3024719451
550PhosphorylationDGRVDSFTDRTSLSP
CCCCCCCCCCCCCCC		21.0227251275
557PhosphorylationTDRTSLSPGSQINVL
CCCCCCCCCCEEEEC		27.4722912867
559PhosphorylationRTSLSPGSQINVLED
CCCCCCCCEEEECCC		28.6428348404
668PhosphorylationGNRVSRLSHLRHHYS
CCHHHHHHHHHHHHC		39.0530631047
683PhosphorylationKKWHRFRFNPKFYSF
CCCCEEECCHHHHHH		18.96-
684PhosphorylationKWHRFRFNPKFYSFL
CCCEEECCHHHHHHH		24.33-
717PhosphorylationSGKRNRIRSSLPWRQ
CCCCCCHHHCCCCCC		31.1123186163
719PhosphorylationKRNRIRSSLPWRQNS
CCCCHHHCCCCCCCC		35.5923186163
728PhosphorylationPWRQNSWKGYSENMR
CCCCCCCCCHHHHHH		28.7128555341
735PhosphorylationKGYSENMRKLRKTHD
CCHHHHHHHHHHHCC		23.0928555341
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPM1E_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPM1E_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPM1E_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARHG7_HUMANARHGEF7physical
11864573
AAPK2_HUMANPRKAA2physical
20801214
AAPK1_HUMANPRKAA1physical
20801214
COX41_HUMANCOX4I1physical
27880917
DNJA3_HUMANDNAJA3physical
27880917
1C07_HUMANHLA-Cphysical
27880917
MD2L1_HUMANMAD2L1physical
27880917
NDUA4_HUMANNDUFA4physical
27880917
ADT2_HUMANSLC25A5physical
27880917
SLN11_HUMANSLFN11physical
27880917
SSRD_HUMANSSR4physical
27880917
STX17_HUMANSTX17physical
27880917
TADBP_HUMANTARDBPphysical
27880917
QCR2_HUMANUQCRC2physical
27880917
TROP_HUMANTROphysical
28514442
PSMG4_HUMANPSMG4physical
28514442
PSMG3_HUMANPSMG3physical
28514442
BRCA2_HUMANBRCA2physical
28514442
FA83H_HUMANFAM83Hphysical
28514442
F192A_HUMANFAM192Aphysical
28514442
PSME3_HUMANPSME3physical
28514442
SPB4_HUMANSERPINB4physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPM1E_HUMAN

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Related Literatures of Post-Translational Modification

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