TROP_HUMAN - dbPTM
TROP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TROP_HUMAN
UniProt AC Q12816
Protein Name Trophinin
Gene Name TRO
Organism Homo sapiens (Human).
Sequence Length 1431
Subcellular Localization
Protein Description Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion..
Protein Sequence MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56UbiquitinationLAATKDSLAMDPPVV
HHHCCHHHCCCCCCC		7.0221890473
56UbiquitinationLAATKDSLAMDPPVV
HHHCCHHHCCCCCCC		7.0221890473
78PhosphorylationTKKAPIKTITKAAPA
CCCCCCCEEECCCCC		34.30-
81UbiquitinationAPIKTITKAAPAAPP
CCCCEEECCCCCCCC		38.41-
99AcetylationANEIATNKPKITWQA
HHHHHCCCCCCCHHH		43.2520167786
146PhosphorylationANKMKRVTAKAAQGS
CCCCHHHHHHHHCCC		26.86-
153PhosphorylationTAKAAQGSQSPTGHE
HHHHHCCCCCCCCCC		18.5330266825
155PhosphorylationKAAQGSQSPTGHEGG
HHHCCCCCCCCCCCC		26.5730266825
157PhosphorylationAQGSQSPTGHEGGTI
HCCCCCCCCCCCCCE		57.3230266825
163PhosphorylationPTGHEGGTIQLKSPL
CCCCCCCCEEECCCC		19.1922199227
168PhosphorylationGGTIQLKSPLQVLKL
CCCEEECCCCEEEEC		39.1630266825
189UbiquitinationIHAPIANESASSQAL
CCCCCCCCCCCCHHH		38.36-
191UbiquitinationAPIANESASSQALIT
CCCCCCCCCCHHHHH		13.66-
196UbiquitinationESASSQALITSIKPK
CCCCCHHHHHHCCCC		3.21-
220UbiquitinationNKAIASATEVSLAAT
HHHHHHHHHHHHHHH		34.13-
220UbiquitinationNKAIASATEVSLAAT
HHHHHHHHHHHHHHH		34.1321890473
225UbiquitinationSATEVSLAATATHTA
HHHHHHHHHHCCCCC		8.68-
236UbiquitinationTHTATTQGQITNETA
CCCCCCCCCCCCCCC		20.83-
266UbiquitinationKARKTIAKVINTDTE
HHHHHHHHHHCCCHH		39.53-
298AcetylationSVVAIRPKKSKGKKA
EEEEEECCCCCCCCC		60.897303111
299AcetylationVVAIRPKKSKGKKAA
EEEEECCCCCCCCCH		61.157303121
301AcetylationAIRPKKSKGKKAASR
EEECCCCCCCCCHHC		81.357303131
301UbiquitinationAIRPKKSKGKKAASR
EEECCCCCCCCCHHC		81.35-
312PhosphorylationAASRGPNSVSEISEA
CHHCCCCCHHHHCCC		30.1022210691
323PhosphorylationISEAPLATQIVTNQA
HCCCCCCHHHHHHHH		26.8922210691
327PhosphorylationPLATQIVTNQALAAT
CCCHHHHHHHHHHHH		24.2022210691
334PhosphorylationTNQALAATLRVKRGS
HHHHHHHHHHHHHHH		14.97-
413PhosphorylationRGKRNRKSKHLNGDE
CCCCCCCCCCCCCCC		23.28-
422PhosphorylationHLNGDERSGSNYRRI
CCCCCCCCCCCCCCC		44.52-
424PhosphorylationNGDERSGSNYRRIPW
CCCCCCCCCCCCCCC		31.75-
426PhosphorylationDERSGSNYRRIPWGR
CCCCCCCCCCCCCCC		11.72-
453UbiquitinationERANKLVKYLLVKDQ
HHHHHHHHHHHCCCC		40.3921890473
453UbiquitinationERANKLVKYLLVKDQ
HHHHHHHHHHHCCCC		40.3921890473
458UbiquitinationLVKYLLVKDQTKIPI
HHHHHHCCCCCCCCC		44.05-
462UbiquitinationLLVKDQTKIPIKRSD
HHCCCCCCCCCCHHH		40.63-
466UbiquitinationDQTKIPIKRSDMLRD
CCCCCCCCHHHHHHH		40.26-
478PhosphorylationLRDVIQEYDEYFPEI
HHHHHHHHHHHHHHH		9.5629759185
481PhosphorylationVIQEYDEYFPEIIER
HHHHHHHHHHHHHHH		22.8729759185
495UbiquitinationRASYTLEKMFRVNLK
HHCHHHHHHHCCCHH		46.59-
502UbiquitinationKMFRVNLKEIDKQSS
HHHCCCHHHHCCCCC		47.63-
578UbiquitinationSLFGEVRKLITDEFV
HHHHHHHHHHCHHHH		49.79-
586UbiquitinationLITDEFVKQKYLEYK
HHCHHHHHHHHHHCC		46.52-
5862-HydroxyisobutyrylationLITDEFVKQKYLEYK
HHCHHHHHHHHHHCC		46.52-
588UbiquitinationTDEFVKQKYLEYKRV
CHHHHHHHHHHCCCC		46.19-
593UbiquitinationKQKYLEYKRVPNSRP
HHHHHHCCCCCCCCC		37.23-
617UbiquitinationRSYHETSKMKVLKFA
CCCCCCCHHHHHHHH		50.5921890473
622UbiquitinationTSKMKVLKFACRVQK
CCHHHHHHHHHHCCC		33.62-
633UbiquitinationRVQKKDPKDWAVQYR
HCCCCCHHHHHHHHH		75.84-
701PhosphorylationGDDAQAWSRFSFEIE
CCCHHHHHHHCEEEH		26.8529083192
1333PhosphorylationSFDRGLSTIIGFGSG
CCCCCCCEEEEECCC		22.96-
1339PhosphorylationSTIIGFGSGSNTSTG
CEEEEECCCCCCCCC		36.47-
1345PhosphorylationGSGSNTSTGFTGEPS
CCCCCCCCCCCCCCC		33.99-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TROP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TROP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TROP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KPCD_HUMANPRKCDphysical
21191175
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TROP_HUMAN

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Related Literatures of Post-Translational Modification

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