SLN11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLN11_HUMAN
• UniProt AC: Q7Z7L1
• Protein Name: Schlafen family member 11 {ECO:0000305}
• Gene Name: SLFN11 {ECO:0000312|HGNC:HGNC:26633}
• Organism: Homo sapiens (Human).
• Sequence Length: 901
• Subcellular Localization: Nucleus . Chromosome . Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061).
• Protein Description: Inhibitor of DNA replication that promotes cell death in response to DNA damage. [PubMed: 22927417]
• Protein Sequence: MEANQCPLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNSGGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIFVKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKRKPKILEEGPFHKIHKGVYQELPNSDPADPNSDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYVPAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVHFCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVEDKYVCSLTTEKWVGMMTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKELQQLLFSVPPGYLRYTPESLWRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	ENRKKLQKIQRDQEK HHHHHHHHHHHHHHH	51.77	24816145
56	Phosphorylation	AACALLNSGGGVIRM HHHHHHHCCCCCEEE	38.49	23401153
66	Ubiquitination	GVIRMAKKVEHPVEM CCEEEEECCCCCHHH	43.23	29967540
97	Ubiquitination	LQAFFETKQQGRCFY HHHHHHHCCCCCEEE	33.17	-
127	Phosphorylation	SVKPRLCSLSSSLYR CCCHHHHHHCHHHHH	35.56	27080861
129	Phosphorylation	KPRLCSLSSSLYRRS CHHHHHHCHHHHHCC	11.11	27080861
130	Phosphorylation	PRLCSLSSSLYRRSE HHHHHHCHHHHHCCC	29.65	27080861
131	Phosphorylation	RLCSLSSSLYRRSET HHHHHCHHHHHCCCC	26.50	27080861
133	Phosphorylation	CSLSSSLYRRSETSV HHHCHHHHHCCCCCC	13.11	27080861
136	Phosphorylation	SSSLYRRSETSVRSM CHHHHHCCCCCCCCC	35.91	-
138	Phosphorylation	SLYRRSETSVRSMDS HHHHCCCCCCCCCCC	33.49	-
139	Phosphorylation	LYRRSETSVRSMDSR HHHCCCCCCCCCCCH	16.10	-
153	Acetylation	REAFCFLKTKRKPKI HHHEEEEECCCCCCH	31.57	23749302
153	Ubiquitination	REAFCFLKTKRKPKI HHHEEEEECCCCCCH	31.57	-
157	Ubiquitination	CFLKTKRKPKILEEG EEEECCCCCCHHCCC	52.82	29967540
159	Ubiquitination	LKTKRKPKILEEGPF EECCCCCCHHCCCCC	64.06	29967540
168	Ubiquitination	LEEGPFHKIHKGVYQ HCCCCCCEECCCCHH	47.05	32015554
171	Ubiquitination	GPFHKIHKGVYQELP CCCCEECCCCHHCCC	54.25	29967540
180	Phosphorylation	VYQELPNSDPADPNS CHHCCCCCCCCCCCC	42.93	27732954
187	Phosphorylation	SDPADPNSDPADLIF CCCCCCCCCHHHHEE	50.81	27732954
196	Ubiquitination	PADLIFQKDYLEYGE HHHHEEECHHHHHCC	37.28	29967540
210	Phosphorylation	EILPFPESQLVEFKQ CCCCCCHHHHEEEHH	29.11	-
216	Ubiquitination	ESQLVEFKQFSTKHF HHHHEEEHHHCHHHH	36.61	29967540
219	Phosphorylation	LVEFKQFSTKHFQEY HEEEHHHCHHHHHHH	33.77	-
220	Phosphorylation	VEFKQFSTKHFQEYV EEEHHHCHHHHHHHH	29.81	-
221	Ubiquitination	EFKQFSTKHFQEYVK EEHHHCHHHHHHHHH	41.02	32015554
228	Ubiquitination	KHFQEYVKRTIPEYV HHHHHHHHHHHCHHC	42.81	29967540
230	Phosphorylation	FQEYVKRTIPEYVPA HHHHHHHHHCHHCHH	34.86	23663014
234	Phosphorylation	VKRTIPEYVPAFANT HHHHHCHHCHHEECC	13.33	23663014
241	Phosphorylation	YVPAFANTGGGYLFI HCHHEECCCCCEEEE	33.50	23663014
245	Phosphorylation	FANTGGGYLFIGVDD EECCCCCEEEEEECC	11.17	23663014
253	Ubiquitination	LFIGVDDKSREVLGC EEEEECCCCCEEECH	47.12	-
262	Ubiquitination	REVLGCAKENVDPDS CEEECHHHCCCCHHH	54.63	29967540
273	Ubiquitination	DPDSLRRKIEQAIYK CHHHHHHHHHHHHHH	44.13	29967540
280	Ubiquitination	KIEQAIYKLPCVHFC HHHHHHHHCCCCEEC	39.58	29967540
338	Phosphorylation	SWIVEDKYVCSLTTE CEEECCEEEEEEECC	21.00	22210691
343	Phosphorylation	DKYVCSLTTEKWVGM CEEEEEEECCCEEEC	19.33	22210691
344	Phosphorylation	KYVCSLTTEKWVGMM EEEEEEECCCEEECC	40.64	22210691
370	Phosphorylation	EDFECQLSLSSGPPL CCEEEEEECCCCCCC	10.59	26074081
372	Phosphorylation	FECQLSLSSGPPLSR EEEEEECCCCCCCCC	29.85	26074081
373	Phosphorylation	ECQLSLSSGPPLSRP EEEEECCCCCCCCCC	61.69	26074081
378	Phosphorylation	LSSGPPLSRPVYSKK CCCCCCCCCCCCCCC	40.07	26074081
385	Acetylation	SRPVYSKKGLEHKKE CCCCCCCCCHHHHHH	63.89	7369377
390	Ubiquitination	SKKGLEHKKELQQLL CCCCHHHHHHHHHHH	38.27	22817900
391	Acetylation	KKGLEHKKELQQLLF CCCHHHHHHHHHHHH	66.61	7369385
391	Ubiquitination	KKGLEHKKELQQLLF CCCHHHHHHHHHHHH	66.61	21890473
411	Phosphorylation	YLRYTPESLWRDLIS CCCCCHHHHHHHHHH	34.14	24719451
429	Ubiquitination	GLEELINKQMQPFFR CHHHHHHHHCCHHHC	39.90	22505724
495	Ubiquitination	TRTAFTLKQKLVNMG HHHHHHHHHHHHHCC	42.18	29967540
497	Ubiquitination	TAFTLKQKLVNMGGY HHHHHHHHHHHCCCC	53.46	29967540
505	Phosphorylation	LVNMGGYTGKVCVRA HHHCCCCCCCEEEEE	33.53	22210691
507	Ubiquitination	NMGGYTGKVCVRAKV HCCCCCCCEEEEEEE	25.35	32015554
605	Ubiquitination	HGLPGSGKTIMAMKI ECCCCCCHHHHHHHH	36.25	29967540
681	Phosphorylation	RTEDGDWYGKAKSIT CCCCCCCCCHHHHHH	17.31	-
683	Acetylation	EDGDWYGKAKSITRR CCCCCCCHHHHHHHH	36.62	7825935
683	Ubiquitination	EDGDWYGKAKSITRR CCCCCCCHHHHHHHH	36.62	-
685	Ubiquitination	GDWYGKAKSITRRAK CCCCCHHHHHHHHHC	45.97	-
739	Ubiquitination	RNADPIAKYLQKEMQ HCCCHHHHHHHHHHH	47.41	22817900
743	Ubiquitination	PIAKYLQKEMQVIRS HHHHHHHHHHHHHHC	53.19	22817900
753	Phosphorylation	QVIRSNPSFNIPTGC HHHHCCCCCCCCCCC	34.87	-
807	Ubiquitination	FDRGYSPKDVAVLVS HHCCCCHHHEEEEEE	59.92	21890473
817	Ubiquitination	AVLVSTAKEVEHYKY EEEEECHHHHHHHHH	63.48	32015554
823	Ubiquitination	AKEVEHYKYELLKAM HHHHHHHHHHHHHHH	33.87	22817900
828	Ubiquitination	HYKYELLKAMRKKRV HHHHHHHHHHHHCCC	53.41	22817900
863	Phosphorylation	RFSGLERSIVFGIHP HHCCCCCEEEEEECC	17.46	-
872	Phosphorylation	VFGIHPRTADPAILP EEEECCCCCCCCHHH	39.60	19845377
887	Phosphorylation	NVLICLASRAKQHLY CHHHHHHHHHHCEEE	21.59	-
890	Ubiquitination	ICLASRAKQHLYIFP HHHHHHHHCEEEEEC	36.82	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLN11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLN11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLN11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SLN11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.