PSMG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMG3_HUMAN
• UniProt AC: Q9BT73
• Protein Name: Proteasome assembly chaperone 3
• Gene Name: PSMG3
• Organism: Homo sapiens (Human).
• Sequence Length: 122
• Protein Description: Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes..
• Protein Sequence: MEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSSVASDVSKPVLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAVAVKDKSMEGLKALREVIRVCQVW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDTPLVI -------CCCCCEEE	10.70	22223895
4	Phosphorylation	----MEDTPLVISKQ ----CCCCCEEEECC	12.76	20068231
9	Phosphorylation	EDTPLVISKQKTEVV CCCCEEEECCCEEEE	22.89	29514088
12	Ubiquitination	PLVISKQKTEVVCGV CEEEECCCEEEEECC	50.84	-
44	Phosphorylation	TQFGKMGTLVSLEPS EECCCCCEEEEECCC	22.08	20068231
47	Phosphorylation	GKMGTLVSLEPSSVA CCCCEEEEECCCCCC	30.08	20068231
55	Phosphorylation	LEPSSVASDVSKPVL ECCCCCCCCCCCCEE	36.07	25627689
58	Phosphorylation	SSVASDVSKPVLTTK CCCCCCCCCCEEEEE	35.91	25627689
59	Ubiquitination	SVASDVSKPVLTTKV CCCCCCCCCEEEEEE	38.71	21890473
65	Ubiquitination	SKPVLTTKVLLGQDE CCCEEEEEEECCCCC	26.17	-
104	2-Hydroxyisobutyrylation	LAVAVKDKSMEGLKA EEEEECCCCHHHHHH	46.08	-
105	Phosphorylation	AVAVKDKSMEGLKAL EEEECCCCHHHHHHH	32.00	24719451
110	Ubiquitination	DKSMEGLKALREVIR CCCHHHHHHHHHHHH	57.12	21890473
110	Acetylation	DKSMEGLKALREVIR CCCHHHHHHHHHHHH	57.12	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAP2_HUMAN	TAP2	physical	21988832
NMI_HUMAN	NMI	physical	22863883
GLYM_HUMAN	SHMT2	physical	22863883
PSB1_HUMAN	PSMB1	physical	17189198
PSB3_HUMAN	PSMB3	physical	17189198
PSB5_HUMAN	PSMB5	physical	17189198
PSB4_HUMAN	PSMB4	physical	17189198
PSA2_HUMAN	PSMA2	physical	17189198
PSA7_HUMAN	PSMA7	physical	17189198
PSA6_HUMAN	PSMA6	physical	17189198
PSA5_HUMAN	PSMA5	physical	17189198
PSMG1_HUMAN	PSMG1	physical	17189198
PSMG2_HUMAN	PSMG2	physical	17189198

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330