PSMG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMG2_HUMAN
• UniProt AC: Q969U7
• Protein Name: Proteasome assembly chaperone 2
• Gene Name: PSMG2 {ECO:0000312|EMBL:AAH13356.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 264
• Subcellular Localization: Nucleus .
• Protein Description: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization..
• Protein Sequence: MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIVLSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTVSASRWKIPSSWRLLFGSGLPPALF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Malonylation	VYSLPSRKLVALQLR EECCCCHHHHHHHHH	52.21	26320211
97	Phosphorylation	LRSIFIKYKSKPFCE HHHHHHHHCCCHHHH	18.71	28152594
99	Phosphorylation	SIFIKYKSKPFCEKL HHHHHHCCCHHHHHH	42.33	28152594
111	Ubiquitination	EKLLSWVKSSGCARV HHHHHHHHHCCCEEE	32.42	21906983
122	Phosphorylation	CARVIVLSSSHSYQR CEEEEEECCCCCCCC	20.92	20068231
123	Phosphorylation	ARVIVLSSSHSYQRN EEEEEECCCCCCCCC	28.10	28152594
124	Phosphorylation	RVIVLSSSHSYQRND EEEEECCCCCCCCCC	17.05	28152594
126	Phosphorylation	IVLSSSHSYQRNDLQ EEECCCCCCCCCCCC	25.55	28152594
127	Phosphorylation	VLSSSHSYQRNDLQL EECCCCCCCCCCCCC	13.18	28152594
136	Phosphorylation	RNDLQLRSTPFRYLL CCCCCCCCCCHHHHC	49.37	21406692
137	Phosphorylation	NDLQLRSTPFRYLLT CCCCCCCCCHHHHCC	21.73	21406692
141	Phosphorylation	LRSTPFRYLLTPSMQ CCCCCHHHHCCHHHH	13.37	21406692
144	Phosphorylation	TPFRYLLTPSMQKSV CCHHHHCCHHHHHHH	15.66	21406692
146	Phosphorylation	FRYLLTPSMQKSVQN HHHHCCHHHHHHHHH	28.72	21406692
149	Ubiquitination	LLTPSMQKSVQNKIK HCCHHHHHHHHHHHH	43.91	21890473
149	Acetylation	LLTPSMQKSVQNKIK HCCHHHHHHHHHHHH	43.91	25953088
149	Ubiquitination	LLTPSMQKSVQNKIK HCCHHHHHHHHHHHH	43.91	21890473
150	Phosphorylation	LTPSMQKSVQNKIKS CCHHHHHHHHHHHHH	16.43	21406692
154	Ubiquitination	MQKSVQNKIKSLNWE HHHHHHHHHHHCCHH	34.13	-
154	Acetylation	MQKSVQNKIKSLNWE HHHHHHHHHHHCCHH	34.13	25953088
154	2-Hydroxyisobutyrylation	MQKSVQNKIKSLNWE HHHHHHHHHHHCCHH	34.13	-
156	Ubiquitination	KSVQNKIKSLNWEEM HHHHHHHHHCCHHHH	50.96	21890473
165	Ubiquitination	LNWEEMEKSRCIPEI CCHHHHHHHCCCCCC	41.72	-
165	Acetylation	LNWEEMEKSRCIPEI CCHHHHHHHCCCCCC	41.72	25953088
166	Phosphorylation	NWEEMEKSRCIPEID CHHHHHHHCCCCCCC	21.05	28555341
188	Ubiquitination	IPGGGITKTLYDESC ECCCCCCCEECCCCC	34.31	-
188	Acetylation	IPGGGITKTLYDESC ECCCCCCCEECCCCC	34.31	26051181
246	Ubiquitination	TVSASRWKIPSSWRL CCCHHHCCCCCHHHH	43.56	21890473
246	Ubiquitination	TVSASRWKIPSSWRL CCCHHHCCCCCHHHH	43.56	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S35F6_HUMAN	SLC35F6	physical	16169070
PSA4_HUMAN	PSMA4	physical	17948026
POMP_HUMAN	POMP	physical	17948026
THOP1_HUMAN	THOP1	physical	22939629
NT2NL_HUMAN	NOTCH2NL	physical	25416956
FBX7_HUMAN	FBXO7	physical	26186194
PSB7_HUMAN	PSMB7	physical	26186194
POMP_HUMAN	POMP	physical	26186194
PSA5_HUMAN	PSMA5	physical	26186194
PSMG4_HUMAN	PSMG4	physical	26186194
PSMG1_HUMAN	PSMG1	physical	26186194
PSMF1_HUMAN	PSMF1	physical	26186194
PSMG3_HUMAN	PSMG3	physical	26186194
PSB9_HUMAN	PSMB9	physical	26186194
SYFA_HUMAN	FARSA	physical	26344197
PA1B2_HUMAN	PAFAH1B2	physical	26344197
PSA1_HUMAN	PSMA1	physical	26344197
PSA2_HUMAN	PSMA2	physical	26344197
PSA4_HUMAN	PSMA4	physical	26344197
PSB4_HUMAN	PSMB4	physical	26344197
PSD13_HUMAN	PSMD13	physical	26344197
PSMG1_HUMAN	PSMG1	physical	26344197
SYWC_HUMAN	WARS	physical	26344197
PSB9_HUMAN	PSMB9	physical	28514442
PSMG1_HUMAN	PSMG1	physical	28514442
PSMG4_HUMAN	PSMG4	physical	28514442
PSMF1_HUMAN	PSMF1	physical	28514442
POMP_HUMAN	POMP	physical	28514442
FBX7_HUMAN	FBXO7	physical	28514442
PSMG3_HUMAN	PSMG3	physical	28514442
PSB7_HUMAN	PSMB7	physical	28514442
PSME1_HUMAN	PSME1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.