dbPTM

NDUA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUA4_HUMAN
UniProt AC	O00483
Protein Name	Cytochrome c oxidase subunit NDUFA4
Gene Name	NDUFA4
Organism	Homo sapiens (Human).
Sequence Length	81
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Matrix side .
Protein Description	Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance..
Protein Sequence	MLRQIIGQAKKHPSLIPLFVFIGTGATGATLYLLRLALFNPDVCWDRNNPEPWNKLGPNDQYKFYSVNVDYSKLKKERPDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	RQIIGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	-
10	"N6,N6-dimethyllysine"	RQIIGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	-
10	Succinylation	RQIIGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	23954790
10	Methylation	RQIIGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	-
10	2-Hydroxyisobutyrylation	RQIIGQAKKHPSLIP HHHHHHHHHCCHHEE	43.67	-
44	Glutathionylation	ALFNPDVCWDRNNPE HHHCCCCCCCCCCCC	4.00	22555962
47	Methylation	NPDVCWDRNNPEPWN CCCCCCCCCCCCCHH	21.96	115484685
55	Methylation	NNPEPWNKLGPNDQY CCCCCHHHCCCCCCE	51.45	88411
55	Acetylation	NNPEPWNKLGPNDQY CCCCCHHHCCCCCCE	51.45	25825284
55	Ubiquitination	NNPEPWNKLGPNDQY CCCCCHHHCCCCCCE	51.45	21906983
62	Phosphorylation	KLGPNDQYKFYSVNV HCCCCCCEEEEEEEC	13.11	-
62	Nitration	KLGPNDQYKFYSVNV HCCCCCCEEEEEEEC	13.11	-
63	Methylation	LGPNDQYKFYSVNVD CCCCCCEEEEEEECC	31.99	30590705
63	Ubiquitination	LGPNDQYKFYSVNVD CCCCCCEEEEEEECC	31.99	21906983
63	Acetylation	LGPNDQYKFYSVNVD CCCCCCEEEEEEECC	31.99	30590705
65	Phosphorylation	PNDQYKFYSVNVDYS CCCCEEEEEEECCHH	13.93	28152594
66	Phosphorylation	NDQYKFYSVNVDYSK CCCEEEEEEECCHHH	15.45	30108239
71	Phosphorylation	FYSVNVDYSKLKKER EEEEECCHHHHHHHC	11.92	28152594
72	Phosphorylation	YSVNVDYSKLKKERP EEEECCHHHHHHHCC	27.35	28152594
73	Acetylation	SVNVDYSKLKKERPD EEECCHHHHHHHCCC	59.08	25825284
73	Ubiquitination	SVNVDYSKLKKERPD EEECCHHHHHHHCCC	59.08	21906983
73	2-Hydroxyisobutyrylation	SVNVDYSKLKKERPD EEECCHHHHHHHCCC	59.08	-
75	Ubiquitination	NVDYSKLKKERPDF- ECCHHHHHHHCCCC-	57.22	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUA4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NDUA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PARK7_HUMAN	PARK7	physical	19822128
A4_HUMAN	APP	physical	21832049
COX7C_HUMAN	COX7C	physical	27499296
TBRG4_HUMAN	TBRG4	physical	27499296
ADT3_HUMAN	SLC25A6	physical	27499296
DIC_HUMAN	SLC25A10	physical	27499296
AFG32_HUMAN	AFG3L2	physical	27499296
TIM21_HUMAN	TIMM21	physical	27499296
NDUA4_HUMAN	NDUFA4	physical	27499296
TMM70_HUMAN	TMEM70	physical	27499296
NDUS4_HUMAN	NDUFS4	physical	27499296
NNTM_HUMAN	NNT	physical	27499296
ACSL1_HUMAN	ACSL1	physical	27499296
NB5R3_HUMAN	CYB5R3	physical	27499296
COX8A_HUMAN	COX8A	physical	27499296
TIDC1_HUMAN	TIMMDC1	physical	27499296
T126A_HUMAN	TMEM126A	physical	27499296
COX20_HUMAN	COX20	physical	27499296
NDUB5_HUMAN	NDUFB5	physical	27499296
NFS1_HUMAN	NFS1	physical	27499296
MPC2_HUMAN	MPC2	physical	27499296
GOLP3_HUMAN	GOLPH3	physical	27499296
CX7A2_HUMAN	COX7A2	physical	27499296
PGES2_HUMAN	PTGES2	physical	27499296
QCR8_HUMAN	UQCRQ	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
KGUA_HUMAN	GUK1	physical	27499296
CX6A1_HUMAN	COX6A1	physical	27499296
ACAD9_HUMAN	ACAD9	physical	27499296
SCMC1_HUMAN	SLC25A24	physical	27499296
COX7R_HUMAN	COX7A2L	physical	27499296
NDUB4_HUMAN	NDUFB4	physical	27499296
NDUA9_HUMAN	NDUFA9	physical	27499296
MAIP1_HUMAN	C2orf47	physical	27499296
NDUF3_HUMAN	NDUFAF3	physical	27499296
CPT2_HUMAN	CPT2	physical	27499296
NDUS6_HUMAN	NDUFS6	physical	27499296
NDUA7_HUMAN	NDUFA7	physical	27499296
COX6C_HUMAN	COX6C	physical	27499296
NDUBB_HUMAN	NDUFB11	physical	27499296
NDUBA_HUMAN	NDUFB10	physical	27499296
NDUS5_HUMAN	NDUFS5	physical	27499296
SCPDL_HUMAN	SCCPDH	physical	27499296
ABCD3_HUMAN	ABCD3	physical	27499296
NDUA6_HUMAN	NDUFA6	physical	27499296
RDH13_HUMAN	RDH13	physical	27499296
SNP29_HUMAN	SNAP29	physical	27499296
ABCB7_HUMAN	ABCB7	physical	27499296
USMG5_HUMAN	USMG5	physical	27499296
CISD1_HUMAN	CISD1	physical	27499296
M2OM_HUMAN	SLC25A11	physical	27499296
COA3_HUMAN	COA3	physical	27499296
NDUS7_HUMAN	NDUFS7	physical	27499296
NDUB3_HUMAN	NDUFB3	physical	27499296
TIM44_HUMAN	TIMM44	physical	27499296
NDUF2_HUMAN	NDUFAF2	physical	27499296
NDUAC_HUMAN	NDUFA12	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
UQCC1_HUMAN	UQCC1	physical	27499296
FIS1_HUMAN	FIS1	physical	27499296
NDUAA_HUMAN	NDUFA10	physical	27499296
OXA1L_HUMAN	OXA1L	physical	27499296
SFXN4_HUMAN	SFXN4	physical	27499296
ATAD1_HUMAN	ATAD1	physical	27499296
MIC60_HUMAN	IMMT	physical	27499296
RMND1_HUMAN	RMND1	physical	27499296
OCAD1_HUMAN	OCIAD1	physical	27499296
NDUA5_HUMAN	NDUFA5	physical	27499296
COX11_HUMAN	COX11	physical	27499296
CMC1_HUMAN	SLC25A12	physical	27499296
NDUS8_HUMAN	NDUFS8	physical	27499296
CCHL_HUMAN	HCCS	physical	27499296
MTX2_HUMAN	MTX2	physical	27499296
NDUAD_HUMAN	NDUFA13	physical	27499296
NDUB8_HUMAN	NDUFB8	physical	27499296
SCO2_HUMAN	SCO2	physical	27499296
UQCC2_HUMAN	UQCC2	physical	27499296
TM177_HUMAN	TMEM177	physical	27499296
TXTP_HUMAN	SLC25A1	physical	27499296
NDUB7_HUMAN	NDUFB7	physical	27499296
TM205_HUMAN	TMEM205	physical	27499296
NDUV1_HUMAN	NDUFV1	physical	27499296
NDUB1_HUMAN	NDUFB1	physical	27499296
NDUS2_HUMAN	NDUFS2	physical	27499296
ATD3A_HUMAN	ATAD3A	physical	27499296
UCRI_HUMAN	UQCRFS1	physical	27499296
MIC19_HUMAN	CHCHD3	physical	27499296
NDUA2_HUMAN	NDUFA2	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
TIM50_HUMAN	TIMM50	physical	27499296
MOT1_HUMAN	SLC16A1	physical	27499296
NDUS1_HUMAN	NDUFS1	physical	27499296
ADT1_HUMAN	SLC25A4	physical	27499296
NDUS3_HUMAN	NDUFS3	physical	27499296
SFXN3_HUMAN	SFXN3	physical	27499296
ATPO_HUMAN	ATP5O	physical	27499296
MCU_HUMAN	MCU	physical	27499296
MTCH2_HUMAN	MTCH2	physical	27499296
QCR7_HUMAN	UQCRB	physical	27499296
HXK2_HUMAN	HK2	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
ROMO1_HUMAN	ROMO1	physical	27499296
ERAL1_HUMAN	ERAL1	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
TIM16_HUMAN	PAM16	physical	27499296
LETM1_HUMAN	LETM1	physical	27499296
DHC24_HUMAN	DHCR24	physical	27499296
NIPS2_HUMAN	GBAS	physical	27499296
GHITM_HUMAN	GHITM	physical	27499296
CT024_HUMAN	C20orf24	physical	27499296
AGK_HUMAN	AGK	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
NIPS1_HUMAN	NIPSNAP1	physical	27499296
ACACA_HUMAN	ACACA	physical	27499296
CHDH_HUMAN	CHDH	physical	27499296
ACSL4_HUMAN	ACSL4	physical	27499296
CISD2_HUMAN	CISD2	physical	27499296
SFXN1_HUMAN	SFXN1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
AIFM2_HUMAN	AIFM2	physical	27499296
NDUV2_HUMAN	NDUFV2	physical	27499296
CYB5B_HUMAN	CYB5B	physical	27499296
FXRD1_HUMAN	FOXRED1	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
TOM40_HUMAN	TOMM40	physical	27499296
CPT1A_HUMAN	CPT1A	physical	27499296
COX5A_HUMAN	COX5A	physical	27499296
NDUA8_HUMAN	NDUFA8	physical	27499296
QCR2_HUMAN	UQCRC2	physical	27499296
SAM50_HUMAN	SAMM50	physical	27499296
MPV17_HUMAN	MPV17	physical	27499296
ATP5J_HUMAN	ATP5J	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
TIM29_HUMAN	C19orf52	physical	27499296
SCO1_HUMAN	SCO1	physical	27499296
RM14_HUMAN	MRPL14	physical	27499296
TIM14_HUMAN	DNAJC19	physical	27499296
ACADV_HUMAN	ACADVL	physical	27499296
MPCP_HUMAN	SLC25A3	physical	27499296
ATPK_HUMAN	ATP5J2	physical	27499296
SDHB_HUMAN	SDHB	physical	27499296
CY1_HUMAN	CYC1	physical	27499296
TAM41_HUMAN	TAMM41	physical	27499296
NDUB9_HUMAN	NDUFB9	physical	27499296
F162A_HUMAN	FAM162A	physical	27499296

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
256000	Leigh syndrome (LS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUA4_HUMAN

Related Literatures of Post-Translational Modification