FXRD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FXRD1_HUMAN
• UniProt AC: Q96CU9
• Protein Name: FAD-dependent oxidoreductase domain-containing protein 1 {ECO:0000312|HGNC:HGNC:26927}
• Gene Name: FOXRED1 {ECO:0000312|HGNC:HGNC:26927}
• Organism: Homo sapiens (Human).
• Sequence Length: 486
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein . According to a report, it is associated with the matrix face of the mitochondrial inner membrane and does not contain any transmembrane region. However, one transmembrane domain is clearly
• Protein Description: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). [PubMed: 20858599]
• Protein Sequence: MIRRVLPHGMGRGLLTRRPGTRRGGFSLDWDGKVSEIKKKIKSILPGRSCDLLQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSVGGICQQFSLPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAMESNVKVQRQEGAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAAGAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLETPLVADTSGAYFRREGLGSNYLGGRSPTEQEEPDPANLEVDHDFFQDKVWPHLALRVPAFETLKVQSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQQAPGIGRAVAEMVLKGRFQTIDLSPFLFTRFYLGEKIQENNII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	VLPHGMGRGLLTRRP CCCCCCCCCCCCCCC	24.56	-
12	Dimethylation	VLPHGMGRGLLTRRP CCCCCCCCCCCCCCC	24.56	-
23	Methylation	TRRPGTRRGGFSLDW CCCCCCCCCCEEECC	49.80	-
33	Ubiquitination	FSLDWDGKVSEIKKK EEECCCCCHHHHHHH	39.86	21890473
33 (in isoform 1)	Ubiquitination	-	39.86	21890473
33	Ubiquitination	FSLDWDGKVSEIKKK EEECCCCCHHHHHHH	39.86	21890473
42	Ubiquitination	SEIKKKIKSILPGRS HHHHHHHHHHCCCCC	40.08	21890473
42 (in isoform 1)	Ubiquitination	-	40.08	21890473
42	Ubiquitination	SEIKKKIKSILPGRS HHHHHHHHHHCCCCC	40.08	21890473
48 (in isoform 2)	Ubiquitination	-	31.97	21890473
87	Phosphorylation	YWLKKLESRRGAIRV HHHHHHHHCCCCEEE	37.40	-
133	Phosphorylation	QLSLFSASFLRNINE EEEHHCHHHHHCHHH	24.50	24719451
166	Ubiquitination	YLLLASEKDAAAMES EEEEEEHHHHHHHHC	50.61	-
176	Ubiquitination	AAMESNVKVQRQEGA HHHHCCCEEEECCCC	36.58	-
184	Acetylation	VQRQEGAKVSLMSPD EEECCCCEEECCCHH	43.12	19829097
189	Phosphorylation	GAKVSLMSPDQLRNK CCEEECCCHHHHHHC	30.53	25850435
259	Ubiquitination	RMLTTDDKAVVLKRI CEECCCCCCHHHHHH	45.98	21890473
259	Ubiquitination	RMLTTDDKAVVLKRI CEECCCCCCHHHHHH	45.98	21890473
259 (in isoform 1)	Ubiquitination	-	45.98	21890473
272	Acetylation	RIHEVHVKMDRSLEY HHEEEEEEECCCCCC	21.87	19608861
279	Phosphorylation	KMDRSLEYQPVECAI EECCCCCCCCEEEEE	24.34	-
458	Ubiquitination	AVAEMVLKGRFQTID HHHHHHHCCCCCEEE	36.31	-
467	Phosphorylation	RFQTIDLSPFLFTRF CCCEEECCHHHHHHH	15.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FXRD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FXRD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FXRD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RT4I1_HUMAN	RTN4IP1	physical	28514442
SUCHY_HUMAN	SUGCT	physical	28514442
COPRS_HUMAN	COPRS	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
CLPX_HUMAN	CLPX	physical	28514442
MCCA_HUMAN	MCCC1	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
SYNM_HUMAN	NARS2	physical	28514442
CPSM_HUMAN	CPS1	physical	28514442
HCFC1_HUMAN	HCFC1	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
MINP1_HUMAN	MINPP1	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
HSP72_HUMAN	HSPA2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• 252010: Mitochondrial complex I deficiency (MT-C1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-272, AND MASS SPECTROMETRY.
PubMed: 19608861