| UniProt ID | SUCHY_HUMAN | |
|---|---|---|
| UniProt AC | Q9HAC7 | |
| Protein Name | Succinate--hydroxymethylglutarate CoA-transferase | |
| Gene Name | SUGCT | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 445 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.. | |
| Protein Sequence | MPSETHAMLATLARVAALRRTCLFSGRGGGRGLWTGRPQSDMNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFAEPQVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVVDQHETH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MPSETHAMLATL ---CCHHHHHHHHHH | 22985185 | ||
| 25 | Phosphorylation | LRRTCLFSGRGGGRG HHHHHCCCCCCCCCC | 24719451 | ||
| 40 | Phosphorylation | LWTGRPQSDMNNIKP CCCCCCCHHCCCCCC | 30242111 | ||
| 124 | Ubiquitination | IKDPKGVKIIKELAA CCCHHHCHHHHHHHH | - | ||
| 124 (in isoform 3) | Ubiquitination | - | - | ||
| 182 | Phosphorylation | PISQRAGYDAVASAV CCHHHHCHHHHHHHH | - | ||
| 190 | Phosphorylation | DAVASAVSGLMHITG HHHHHHHCCCHHHCC | - | ||
| 211 | Phosphorylation | VRPGVAMTDLATGLY CCCCCCHHHHHHHHH | 23663014 | ||
| 215 | Phosphorylation | VAMTDLATGLYAYGA CCHHHHHHHHHHHHH | 23663014 | ||
| 218 | Phosphorylation | TDLATGLYAYGAIMA HHHHHHHHHHHHHHH | 23663014 | ||
| 220 | Phosphorylation | LATGLYAYGAIMAGL HHHHHHHHHHHHHHH | 23663014 | ||
| 278 | Phosphorylation | AHGSIVPYQAFKTKD CCCCCCCEECEECCC | 22817900 | ||
| 315 | Acetylation | PELIDNSKYKTNHLR HHHHCCCCCCCCCCE | 25038526 | ||
| 401 | Acetylation | AVRYSKFKMSEARPP CCCCCEECCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SUCHY_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SUCHY_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SUCHY_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SUCHY_HUMAN | SUGCT | physical | 27499296 | |
| RM01_HUMAN | MRPL1 | physical | 27499296 | |
| CYC_HUMAN | CYCS | physical | 27499296 | |
| ODBA_HUMAN | BCKDHA | physical | 27499296 | |
| AT5F1_HUMAN | ATP5F1 | physical | 27499296 | |
| ECH1_HUMAN | ECH1 | physical | 27499296 | |
| ATPG_HUMAN | ATP5C1 | physical | 27499296 | |
| RM54_HUMAN | MRPL54 | physical | 27499296 | |
| C1QBP_HUMAN | C1QBP | physical | 27499296 | |
| PDIP2_HUMAN | POLDIP2 | physical | 27499296 | |
| MPPA_HUMAN | PMPCA | physical | 27499296 | |
| MIA40_HUMAN | CHCHD4 | physical | 27499296 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 231690 | Glutaric aciduria 3 (GA3) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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