dbPTM

MPV17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPV17_HUMAN
UniProt AC	P39210
Protein Name	Protein Mpv17
Gene Name	MPV17
Organism	Homo sapiens (Human).
Sequence Length	176
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance..
Protein Sequence	MALWRAYQRALAAHPWKVQVLTAGSLMGLGDIISQQLVERRGLQEHQRGRTLTMVSLGCGFVGPVVGGWYKVLDRFIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGALNGLSAQDNWAKLQRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	PWKVQVLTAGSLMGL CCEEEEEEHHHHCCH	30.07	24043423
25	Phosphorylation	VQVLTAGSLMGLGDI EEEEEHHHHCCHHHH	16.84	24043423
34	Phosphorylation	MGLGDIISQQLVERR CCHHHHHHHHHHHHC	16.53	24043423
80	Phosphorylation	LDRFIPGTTKVDALK HHHHCCCCCHHHHHH	20.35	-
82	Ubiquitination	RFIPGTTKVDALKKM HHCCCCCHHHHHHHH	37.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MPV17_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MPV17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPV17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM23_HUMAN	MRPL23	physical	22939629
RM11_HUMAN	MRPL11	physical	22939629
RM32_HUMAN	MRPL32	physical	22939629
NDUB9_HUMAN	NDUFB9	physical	22939629
RM17_HUMAN	MRPL17	physical	22939629
RHOA_HUMAN	RHOA	physical	22939629
NDUB7_HUMAN	NDUFB7	physical	22939629
PUF60_HUMAN	PUF60	physical	22939629
VDAC2_HUMAN	VDAC2	physical	22939629
NB5R1_HUMAN	CYB5R1	physical	22939629
RALA_HUMAN	RALA	physical	22939629
SFXN3_HUMAN	SFXN3	physical	22939629
RM40_HUMAN	MRPL40	physical	22939629
NDUB4_HUMAN	NDUFB4	physical	22939629
RM22_HUMAN	MRPL22	physical	22939629
RM13_HUMAN	MRPL13	physical	22939629
NDUAC_HUMAN	NDUFA12	physical	22939629
VATD_HUMAN	ATP6V1D	physical	22939629
NDUAA_HUMAN	NDUFA10	physical	22939629
RM38_HUMAN	MRPL38	physical	22939629
NDUS7_HUMAN	NDUFS7	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RAI3_HUMAN	GPRC5A	physical	22939629
SCFD1_HUMAN	SCFD1	physical	22939629
PTCD3_HUMAN	PTCD3	physical	22939629
NDUS8_HUMAN	NDUFS8	physical	22939629
NDUB6_HUMAN	NDUFB6	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
UCRI_HUMAN	UQCRFS1	physical	22939629
RT14_HUMAN	MRPS14	physical	22939629
RM44_HUMAN	MRPL44	physical	22939629
QCR6_HUMAN	UQCRH	physical	22939629
NDUB5_HUMAN	NDUFB5	physical	22939629
NDUS6_HUMAN	NDUFS6	physical	22939629
RT16_HUMAN	MRPS16	physical	22939629
RM51_HUMAN	MRPL51	physical	22939629
SCMC1_HUMAN	SLC25A24	physical	22939629
MSLN_HUMAN	MSLN	physical	22939629

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPV17_HUMAN

Related Literatures of Post-Translational Modification