MSLN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSLN_HUMAN
• UniProt AC: Q13421
• Protein Name: Mesothelin
• Gene Name: MSLN
• Organism: Homo sapiens (Human).
• Sequence Length: 630
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; Megakaryocyte-potentiating factor: Secreted.; Isoform 3: Secreted.
• Protein Description: Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro..
• Protein Sequence: MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	GVLANPPNISSLSPR CCCCCCCCHHHCCHH	48.29	UniProtKB CARBOHYD
60	Phosphorylation	ANPPNISSLSPRQLL CCCCCHHHCCHHHHC	29.12	24719451
62	Phosphorylation	PPNISSLSPRQLLGF CCCHHHCCHHHHCCC	21.71	24719451
92	Ubiquitination	LAVALAQKNVKLSTE HHHHHHHCCCCCCHH	59.09	29967540
95	Ubiquitination	ALAQKNVKLSTEQLR HHHHCCCCCCHHHHH	46.22	29967540
145	Phosphorylation	TRFFSRITKANVDLL HHHHHHHHHHCCCCC	24.01	24114839
175	Phosphorylation	ACWGVRGSLLSEADV HHHHCCCCCCCHHHH	18.64	20068231
178	Phosphorylation	GVRGSLLSEADVRAL HCCCCCCCHHHHHHH	35.71	20068231
200	Phosphorylation	PGRFVAESAEVLLPR CCCHHHHCHHHHHHH	21.71	28355574
262	Phosphorylation	LGQPIIRSIPQGIVA HCCHHHHHCCCCHHH	28.36	28348404
280	Phosphorylation	QRSSRDPSWRQPERT HHCCCCCCCCCCCCC	38.90	26091039
319	Ubiquitination	DESLIFYKKWELEAC CHHHHHHHHHHHHHH	40.43	29967540
353	Ubiquitination	YEQLDVLKHKLDELY HHHHHHHHHHHHHHC	38.24	29967540
386	Ubiquitination	MSPEDIRKWNVTSLE CCHHHHHHCCCCCHH	43.38	29967540
388	N-linked_Glycosylation	PEDIRKWNVTSLETL HHHHHHCCCCCHHHH	30.17	UniProtKB CARBOHYD
479	Ubiquitination	DLDTCDPRQLDVLYP CCCCCCHHHHHCCCH	36.12	29967540
487	Ubiquitination	QLDVLYPKARLAFQN HHHCCCHHHHHEEEC	32.36	29967540
496	N-linked_Glycosylation	RLAFQNMNGSEYFVK HHEEECCCCCCEEEE	59.39	UniProtKB CARBOHYD
520	Phosphorylation	TEDLKALSQQNVSMD HHHHHHHHHCCCCCH	34.28	20068231
523	N-linked_Glycosylation	LKALSQQNVSMDLAT HHHHHHCCCCCHHHH	21.86	UniProtKB CARBOHYD
525	Phosphorylation	ALSQQNVSMDLATFM HHHHCCCCCHHHHHH	17.71	20068231
530	Phosphorylation	NVSMDLATFMKLRTD CCCCHHHHHHHHCCC	31.40	20068231
541	Ubiquitination	LRTDAVLPLTVAEVQ HCCCCCCCCCHHHHH	21.27	29967540
549	Ubiquitination	LTVAEVQKLLGPHVE CCHHHHHHHHCCCHH	51.35	29967540
573 (in isoform 2)	Phosphorylation	-	22.09	24043423
586 (in isoform 2)	Phosphorylation	-	5.27	24043423
592 (in isoform 2)	Phosphorylation	-	50.23	24043423
606	GPI-anchor	LSMQEALSGTPCLLG HHHHHHHCCCCCCCC	47.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
200	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSLN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSLN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM16_HUMAN	MRPL16	physical	22939629
NDUB9_HUMAN	NDUFB9	physical	22939629
MRM3_HUMAN	RNMTL1	physical	22939629
RM01_HUMAN	MRPL1	physical	22939629
VATA_HUMAN	ATP6V1A	physical	22939629
RALA_HUMAN	RALA	physical	22939629
NDUB5_HUMAN	NDUFB5	physical	22939629
RM28_HUMAN	MRPL28	physical	22939629
ZBT43_HUMAN	ZBTB43	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D09767: Amatuximab (USAN)
• DrugBank
• There are no disease associations of PTM sites.