RM11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM11_HUMAN
• UniProt AC: Q9Y3B7
• Protein Name: 39S ribosomal protein L11, mitochondrial
• Gene Name: MRPL11
• Organism: Homo sapiens (Human).
• Sequence Length: 192
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MSKLGRAARGLRKPEVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARQTGKEVAGLVTLKHVYEIARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKLGRAAR ------CCHHHHHHH	36.27	24719451
19 (in isoform 2)	Phosphorylation	-	1.89	20068231
43	Ubiquitination	GPVLGQRGVSINQFC HHHCCCCCCCHHHHH	15.05	22817900
45	Phosphorylation	VLGQRGVSINQFCKE HCCCCCCCHHHHHHH	20.74	30108239
47	Ubiquitination	GQRGVSINQFCKEFN CCCCCCHHHHHHHHH	22.75	21890473
47	Ubiquitination	GQRGVSINQFCKEFN CCCCCCHHHHHHHHH	22.75	21890473
51	Succinylation	VSINQFCKEFNERTK CCHHHHHHHHHHHCC	67.63	23954790
68	Phosphorylation	KEGIPLPTKILVKPD HHCCCCCCEEEECCC	38.10	-
69	Ubiquitination	EGIPLPTKILVKPDR HCCCCCCEEEECCCC	31.91	22817900
73	Ubiquitination	LPTKILVKPDRTFEI CCCEEEECCCCEEEE	37.44	21890473
73	Ubiquitination	LPTKILVKPDRTFEI CCCEEEECCCCEEEE	37.44	21890473
76	Methylation	KILVKPDRTFEIKIG EEEECCCCEEEEEEC	50.25	115483707
86	O-linked_Glycosylation	EIKIGQPTVSYFLKA EEEECCCCHHHHHHH	17.75	OGP
113	Phosphorylation	KEVAGLVTLKHVYEI CCHHHHHHHHHHHHH	34.82	20068231
115	Acetylation	VAGLVTLKHVYEIAR HHHHHHHHHHHHHHH	22.97	30590461
118	Phosphorylation	LVTLKHVYEIARIKA HHHHHHHHHHHHHHC	11.01	29496907
131	Ubiquitination	KAQDEAFALQDVPLS HCCCCHHHCCCCCHH	16.03	24816145
138	Phosphorylation	ALQDVPLSSVVRSII HCCCCCHHHHHHHHH	18.28	-
139	Phosphorylation	LQDVPLSSVVRSIIG CCCCCHHHHHHHHHH	32.11	-
143	Ubiquitination	PLSSVVRSIIGSARS CHHHHHHHHHHHHHH	13.62	29967540
153	Ubiquitination	GSARSLGIRVVKDLS HHHHHHCCEEEECCC	3.51	29967540
157	Ubiquitination	SLGIRVVKDLSSEEL HHCCEEEECCCHHHH	50.52	24816145
160	Phosphorylation	IRVVKDLSSEELAAF CEEEECCCHHHHHHH	45.92	-
169	Succinylation	EELAAFQKERAIFLA HHHHHHHHHHHHHHH	42.59	23954790
169	2-Hydroxyisobutyrylation	EELAAFQKERAIFLA HHHHHHHHHHHHHHH	42.59	-
169	Acetylation	EELAAFQKERAIFLA HHHHHHHHHHHHHHH	42.59	23236377
169	Ubiquitination	EELAAFQKERAIFLA HHHHHHHHHHHHHHH	42.59	29967540
179	Ubiquitination	AIFLAAQKEADLAAQ HHHHHHHHHHHHHHH	50.58	29967540
191	Malonylation	AAQEEAAKK------ HHHHHHHHC------	67.09	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RM16_HUMAN	MRPL16	physical	22939629
RM15_HUMAN	MRPL15	physical	22939629
RM39_HUMAN	MRPL39	physical	22939629
RM13_HUMAN	MRPL13	physical	22939629
RM12_HUMAN	MRPL12	physical	22939629
RM40_HUMAN	MRPL40	physical	22939629
RM32_HUMAN	MRPL32	physical	22939629
RM38_HUMAN	MRPL38	physical	22939629
RM19_HUMAN	MRPL19	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629
TM177_HUMAN	TMEM177	physical	22939629
SSBP_HUMAN	SSBP1	physical	22939629
HMBX1_HUMAN	HMBOX1	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
MOT9_HUMAN	SLC16A9	physical	25416956
ACPM_HUMAN	NDUFAB1	physical	26344197
RPC1_HUMAN	POLR3A	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.