TIM21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM21_HUMAN
• UniProt AC: Q9BVV7
• Protein Name: Mitochondrial import inner membrane translocase subunit Tim21
• Gene Name: TIMM21
• Organism: Homo sapiens (Human).
• Sequence Length: 248
• Subcellular Localization: Mitochondrion membrane ; Single-pass membrane protein .
• Protein Description: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes..
• Protein Sequence: MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCGLQYQKKTLRPRCILGVTQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFGESVKGYGEVTRRGRRQHVRFTEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGSGEYDFRYIFVEIESYPRRTIIIEDNRSQDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	AKRLLLPYIVLNKAC HHHHHHHHHHHCHHH	12.02	22817900
32	Ubiquitination	LPYIVLNKACLKTEP HHHHHHCHHHHCCCC	35.99	-
61	O-linked_Glycosylation	PRCILGVTQKTIWTQ CCEEEEECCCCCHHC	23.66	30379171
71	Phosphorylation	TIWTQGPSPRKAKED CCHHCCCCCCCCCCC	44.13	30631047
80	Phosphorylation	RKAKEDGSKQVSVHR CCCCCCCCCEEEEEH	32.03	-
98	O-linked_Glycosylation	GGTAVPTSQKVKEAG CCCCCCCHHHHHHHC	23.18	30379171
100	Ubiquitination	TAVPTSQKVKEAGRD CCCCCHHHHHHHCCC	55.85	-
136	O-linked_Glycosylation	FKELFSSSSPSKIYG HHHHHCCCCHHHHHH	45.10	OGP
137	O-linked_Glycosylation	KELFSSSSPSKIYGR HHHHCCCCHHHHHHH	34.83	OGP
139	O-linked_Glycosylation	LFSSSSPSKIYGRAL HHCCCCHHHHHHHHH	33.36	OGP
151	Phosphorylation	RALEKCRSHPEVIGV HHHHHHHHCCCEEEE	53.52	30108239
162	Phosphorylation	VIGVFGESVKGYGEV EEEEECCCCCCCCCC	29.52	22210691
185	Ubiquitination	VRFTEYVKDGLKHTC EEEHHHHCCCCCEEE	45.22	21890473
194	Acetylation	GLKHTCVKFYIEGSE CCCEEEEEEEEECCC	34.30	26051181
196	Phosphorylation	KHTCVKFYIEGSEPG CEEEEEEEEECCCCC	7.73	-
204	Ubiquitination	IEGSEPGKQGTVYAQ EECCCCCCEEEEEEE	57.16	-
207	Phosphorylation	SEPGKQGTVYAQVKE CCCCCEEEEEEEEEE	14.09	-
209	Phosphorylation	PGKQGTVYAQVKENP CCCEEEEEEEEEECC	7.37	-
218	Phosphorylation	QVKENPGSGEYDFRY EEEECCCCCCEEEEE	29.70	-
221	Phosphorylation	ENPGSGEYDFRYIFV ECCCCCCEEEEEEEE	24.73	-
245	Phosphorylation	IIIEDNRSQDD---- EEEECCCCCCC----	44.19	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM21_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TIM21_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.