SFXN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFXN4_HUMAN
• UniProt AC: Q6P4A7
• Protein Name: Sideroflexin-4
• Gene Name: SFXN4
• Organism: Homo sapiens (Human).
• Sequence Length: 337
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Potential iron transporter..
• Protein Sequence: MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVESIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPTVFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGVIPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRIAGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMVPFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLEQEEET ------CCHHHCCCC	40.38	30108239
2	Acetylation	------MSLEQEEET ------CCHHHCCCC	40.38	22814378
9	Phosphorylation	SLEQEEETQPGRLLG CHHHCCCCCCCCCCC	43.26	29759185
81 (in isoform 3)	Ubiquitination	-	21.04	21890473
81	Ubiquitination	DVSSPASADQRIQEA CCCCCCCHHHHHHHH	21.04	21890473
90	Ubiquitination	QRIQEAWKRSLATVH HHHHHHHHHHHCCCC	38.87	-
97	Ubiquitination	KRSLATVHPDSSNLI HHHHCCCCCCCCCCH	18.98	22817900
101	Phosphorylation	ATVHPDSSNLIPKLF CCCCCCCCCCHHHHH	42.93	24247654
106	Ubiquitination	DSSNLIPKLFRPAAF CCCCCHHHHHCHHHH	53.95	21890473
106 (in isoform 1)	Ubiquitination	-	53.95	21890473
107	Ubiquitination	SSNLIPKLFRPAAFL CCCCHHHHHCHHHHH	3.55	22817900
107 (in isoform 3)	Ubiquitination	-	3.55	21890473
114 (in isoform 3)	Ubiquitination	-	2.47	21890473
114	Ubiquitination	LFRPAAFLPFMAPTV HHCHHHHHHHCCCEE	2.47	21890473
160	Ubiquitination	GNRSYTCKPLERSLL CCCCEECCCCHHHHH	44.85	-
188	Acetylation	IPQFVQMKYGLTGPW HHHHHHHHHCCCHHH	21.05	-
188 (in isoform 2)	Ubiquitination	-	21.05	21890473
188	Ubiquitination	IPQFVQMKYGLTGPW HHHHHHHHHCCCHHH	21.05	21890473
197	Ubiquitination	GLTGPWIKRLLPVIF CCCHHHHHHHHHHHH	32.88	22817900
197	Acetylation	GLTGPWIKRLLPVIF CCCHHHHHHHHHHHH	32.88	19608861
197 (in isoform 1)	Ubiquitination	-	32.88	21890473
209	Phosphorylation	VIFLVQASGMNVYMS HHHHHCCCCCCEEEC	22.83	-
214 (in isoform 2)	Ubiquitination	-	5.60	21890473
214	Ubiquitination	QASGMNVYMSRSLES CCCCCCEEECCCHHH	5.60	22817900
221 (in isoform 2)	Ubiquitination	-	34.59	21890473
221	Ubiquitination	YMSRSLESIKGIAVM EECCCHHHCCCEEEE	34.59	21890473
223	Ubiquitination	SRSLESIKGIAVMDK CCCHHHCCCEEEECC	54.25	22817900
223 (in isoform 1)	Ubiquitination	-	54.25	21890473
230 (in isoform 1)	Ubiquitination	-	49.80	21890473
230	Ubiquitination	KGIAVMDKEGNVLGH CCEEEECCCCCCCCC	49.80	22817900
324	Phosphorylation	SLEEKIQSPTEETEI CHHHHCCCCCCCCCC	36.94	26471730
326	Phosphorylation	EEKIQSPTEETEIFY HHHCCCCCCCCCCEE	52.26	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFXN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFXN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFXN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SFXN4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615578: Combined oxidative phosphorylation deficiency 18 (COXPD18)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-197, AND MASS SPECTROMETRY.
PubMed: 19608861