NDUF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUF2_HUMAN
• UniProt AC: Q8N183
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2
• Gene Name: NDUFAF2
• Organism: Homo sapiens (Human).
• Sequence Length: 169
• Subcellular Localization: Mitochondrion .
• Protein Description: Acts as a molecular chaperone for mitochondrial complex I assembly. [PubMed: 16200211 Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone]
• Protein Sequence: MGWSQDLFRALWRSLSREVKEHVGTDQFGNKYYYIPQYKNWRGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQPGSWMPRDGKSHNQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	GTDQFGNKYYYIPQY CCCCCCCEEEEECCC		21890473
39	Ubiquitination	YYYIPQYKNWRGQTI EEEECCCCCCCCCHH		21890473
45	Phosphorylation	YKNWRGQTIREKRIV CCCCCCCHHHHHHHH		-
57	2-Hydroxyisobutyrylation	RIVEAANKKEVDYEA HHHHHHHHCCCCCCC		-
69	Phosphorylation	YEAGDIPTEWEAWIR CCCCCCCCHHHHHHH		-
78	Phosphorylation	WEAWIRRTRKTPPTM HHHHHHHHCCCCCCH		23403867
81	Phosphorylation	WIRRTRKTPPTMEEI HHHHHCCCCCCHHHH		23403867
85	Sulfoxidation	TRKTPPTMEEILKNE HCCCCCCHHHHHHCH		21406390
101	2-Hydroxyisobutyrylation	HREEIKIKSQDFYEK HHHHHCCCCHHHHHH		-
101	Ubiquitination	HREEIKIKSQDFYEK HHHHHCCCCHHHHHH		-
102	Phosphorylation	REEIKIKSQDFYEKE HHHHCCCCHHHHHHH		25159151
106	Phosphorylation	KIKSQDFYEKEKLLS CCCCHHHHHHHHHHC		25884760
116	Phosphorylation	EKLLSKETSEELLPP HHHHCCCCHHHHCCC		25627689
117	Phosphorylation	KLLSKETSEELLPPP HHHCCCCHHHHCCCC		25627689
127	Phosphorylation	LLPPPVQTQIKGHAS HCCCCCCCCCCCCCC		-
134	Phosphorylation	TQIKGHASAPYFGKE CCCCCCCCCCCCCCC		23401153
137	Phosphorylation	KGHASAPYFGKEEPS CCCCCCCCCCCCCCC		30576142
140	Acetylation	ASAPYFGKEEPSVAP CCCCCCCCCCCCCCC		26051181
144	Phosphorylation	YFGKEEPSVAPSSTG CCCCCCCCCCCCCCC		29978859
148	Phosphorylation	EEPSVAPSSTGKTFQ CCCCCCCCCCCCCCC		25159151
149	Phosphorylation	EPSVAPSSTGKTFQP CCCCCCCCCCCCCCC		25159151
150	Phosphorylation	PSVAPSSTGKTFQPG CCCCCCCCCCCCCCC		21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS24_HUMAN	RPS24	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
PPIF_HUMAN	PPIF	physical	22939629
SUGP2_HUMAN	SUGP2	physical	22939629
SON_HUMAN	SON	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.