CHDH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHDH_HUMAN
• UniProt AC: Q8NE62
• Protein Name: Choline dehydrogenase, mitochondrial
• Gene Name: CHDH
• Organism: Homo sapiens (Human).
• Sequence Length: 594
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Sequence: MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGSAGCVLAGRLTEDPAERVLLLEAGPKDVLAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQRGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHELGASRYRGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSAACAYLHPALSRTNLKAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKEVILSGGAINSPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLRKVCIGLEWLWKFTGEGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPTQQEAYQVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAPFRGKELQPGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVYKPRTLATQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
181	Methylation	ELGASRYRGADGPLR CCCCCCCCCCCCCCE	32.48	-
190	Phosphorylation	ADGPLRVSRGKTNHP CCCCCEECCCCCCCC	28.96	21888424
244	Phosphorylation	RWSAACAYLHPALSR CHHHHHHHHCHHHHC	12.86	25693802
250	Phosphorylation	AYLHPALSRTNLKAE HHHCHHHHCCCHHHH	38.88	-
277	Phosphorylation	TRAVGVEYVKNGQSH CCEEEEEEEECCCCE	17.83	-
317	Acetylation	IGNADDLKKLGIPVV CCCHHHHHHHCCCEE	53.60	25038526
357	Ubiquitination	ITLHSAQKPLRKVCI EECCCCCHHHHHHHH	45.82	-
431	Phosphorylation	VGPMRGTSVGWLKLR CCCCCCCCEEEEEEE	22.81	22798277
436	Succinylation	GTSVGWLKLRSANPQ CCCEEEEEEECCCCC	35.03	-
436	Succinylation	GTSVGWLKLRSANPQ CCCEEEEEEECCCCC	35.03	-
484	Succinylation	ALAPFRGKELQPGSH HHCCCCCCCCCCCCC	51.50	-
484	Acetylation	ALAPFRGKELQPGSH HHCCCCCCCCCCCCC	51.50	-
484	Succinylation	ALAPFRGKELQPGSH HHCCCCCCCCCCCCC	51.50	-
490	Phosphorylation	GKELQPGSHIQSDKE CCCCCCCCCCCCHHH	24.89	28857561
496	Succinylation	GSHIQSDKEIDAFVR CCCCCCHHHCCHHHH	62.91	-
496	Acetylation	GSHIQSDKEIDAFVR CCCCCCHHHCCHHHH	62.91	25038526
496	Succinylation	GSHIQSDKEIDAFVR CCCCCCHHHCCHHHH	62.91	-
580	Acetylation	GQPALWDKDVPVYKP CCCCCCCCCCCCCCC	49.39	-
585	Phosphorylation	WDKDVPVYKPRTLAT CCCCCCCCCCCCCCC	14.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHDH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHDH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHDH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEZ6_HUMAN	SEZ6	physical	21900206
RL8_HUMAN	RPL8	physical	21900206
NT2NL_HUMAN	NOTCH2NL	physical	25416956
SQSTM_HUMAN	SQSTM1	physical	25483962
MLP3A_HUMAN	MAP1LC3A	physical	25483962

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.