MCU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCU_HUMAN
• UniProt AC: Q8NE86
• Protein Name: Calcium uniporter protein, mitochondrial {ECO:0000303|PubMed:21685886}
• Gene Name: MCU {ECO:0000303|PubMed:21685886, ECO:0000312|HGNC:HGNC:23526}
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. [PubMed: 21685888]
• Protein Sequence: MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAAAGRSLLLLLSS CCCHHHHHHHHHHHC	23.58	23403867
14	Phosphorylation	RSLLLLLSSRGGGGG HHHHHHHHCCCCCCC	20.26	23403867
15	Phosphorylation	SLLLLLSSRGGGGGG HHHHHHHCCCCCCCC	34.61	23403867
57	Phosphorylation	TVHQRIASWQNLGAV HHHHHHHHHHHCCEE	27.16	23051746
92	Phosphorylation	VISVRLPSRRERCQF EEEEECCCCHHHCEE	48.86	23051746
115	Ubiquitination	VGVFLRQLQEEDRGI HHHHHHHHHHHHCCC	5.82	29967540
157	Phosphorylation	KLVINDLTYHVRPPK EEEEEHHHCCCCCCC	17.91	22210691
158	Phosphorylation	LVINDLTYHVRPPKR EEEEHHHCCCCCCCC	12.96	22210691
162	Ubiquitination	DLTYHVRPPKRDLLS HHHCCCCCCCCCCCC	37.36	29967540
164	2-Hydroxyisobutyrylation	TYHVRPPKRDLLSHE HCCCCCCCCCCCCCC	62.32	-
164	Ubiquitination	TYHVRPPKRDLLSHE HCCCCCCCCCCCCCC	62.32	29967540
170	Ubiquitination	PKRDLLSHENAATLN CCCCCCCCCCCCHHH	32.09	23503661
199	Acetylation	IEQHQLNKERELIER HHHHHHHHHHHHHHH	67.74	25953088
211 (in isoform 1)	Ubiquitination	-	56.59	21906983
211	Succinylation	IERLEDLKEQLAPLE HHHHHHHHHHHHCHH	56.59	23954790
211	2-Hydroxyisobutyrylation	IERLEDLKEQLAPLE HHHHHHHHHHHHCHH	56.59	-
211	Acetylation	IERLEDLKEQLAPLE HHHHHHHHHHHHCHH	56.59	26051181
211	Ubiquitination	IERLEDLKEQLAPLE HHHHHHHHHHHHCHH	56.59	22817900
218	Ubiquitination	KEQLAPLEKVRIEIS HHHHHCHHHHHHEEE	48.74	22817900
219	2-Hydroxyisobutyrylation	EQLAPLEKVRIEISR HHHHCHHHHHHEEEH	44.49	-
219	Ubiquitination	EQLAPLEKVRIEISR HHHHCHHHHHHEEEH	44.49	23503661
219	Acetylation	EQLAPLEKVRIEISR HHHHCHHHHHHEEEH	44.49	23954790
226	Ubiquitination	KVRIEISRKAEKRTT HHHHEEEHHHCCCEE	48.11	23503661
232	Phosphorylation	SRKAEKRTTLVLWGG EHHHCCCEEEEEECH	35.23	-
233	Phosphorylation	RKAEKRTTLVLWGGL HHHCCCEEEEEECHH	20.92	-
267	Ubiquitination	WDIMEPVTYFITYGS CCCCCCCEEEEHHHH	24.35	29967540
283	Ubiquitination	MAMYAYFVMTRQEYV HHHHHHHHHHCCHHC	2.20	29967540
289	Phosphorylation	FVMTRQEYVYPEARD HHHHCCHHCCCCCCC	9.28	-
291	Phosphorylation	MTRQEYVYPEARDRQ HHCCHHCCCCCCCCE	8.41	-
295	Ubiquitination	EYVYPEARDRQYLLF HHCCCCCCCCEEEEE	37.67	29967540
299	Phosphorylation	PEARDRQYLLFFHKG CCCCCCEEEEEEECC	13.28	-
311	Ubiquitination	HKGAKKSRFDLEKYN ECCCCCCCCCHHHHH	37.67	29967540
316	Ubiquitination	KSRFDLEKYNQLKDA CCCCCHHHHHHHHHH	57.72	29967540
316	2-Hydroxyisobutyrylation	KSRFDLEKYNQLKDA CCCCCHHHHHHHHHH	57.72	-
316	Acetylation	KSRFDLEKYNQLKDA CCCCCHHHHHHHHHH	57.72	25825284
321	Succinylation	LEKYNQLKDAIAQAE HHHHHHHHHHHHHHH	35.04	23954790
329	Sulfoxidation	DAIAQAEMDLKRLRD HHHHHHHHHHHHCCC	9.07	21406390
332	Ubiquitination	AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC	45.16	29967540
332	Acetylation	AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC	45.16	23236377
332	2-Hydroxyisobutyrylation	AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC	45.16	-
332	Malonylation	AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC	45.16	26320211
332	Succinylation	AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC	45.16	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
57	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
57	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
92	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
92	S	Phosphorylation	Kinase	PKCD	Q05655	PSP
92	S	Phosphorylation	Kinase	PKCE	Q02156	PSP
92	S	Phosphorylation	Kinase	CAMK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCU_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MRP1_HUMAN	ABCC1	physical	22939629
S38A2_HUMAN	SLC38A2	physical	22939629
ERLN2_HUMAN	ERLIN2	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.