MCU_HUMAN - dbPTM
MCU_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCU_HUMAN
UniProt AC Q8NE86
Protein Name Calcium uniporter protein, mitochondrial {ECO:0000303|PubMed:21685886}
Gene Name MCU {ECO:0000303|PubMed:21685886, ECO:0000312|HGNC:HGNC:23526}
Organism Homo sapiens (Human).
Sequence Length 351
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. [PubMed: 21685888]
Protein Sequence MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAAAAGRSLLLLLSS
CCCHHHHHHHHHHHC
23.5823403867
14PhosphorylationRSLLLLLSSRGGGGG
HHHHHHHHCCCCCCC
20.2623403867
15PhosphorylationSLLLLLSSRGGGGGG
HHHHHHHCCCCCCCC
34.6123403867
57PhosphorylationTVHQRIASWQNLGAV
HHHHHHHHHHHCCEE
27.1623051746
92PhosphorylationVISVRLPSRRERCQF
EEEEECCCCHHHCEE
48.8623051746
115UbiquitinationVGVFLRQLQEEDRGI
HHHHHHHHHHHHCCC
5.8229967540
157PhosphorylationKLVINDLTYHVRPPK
EEEEEHHHCCCCCCC
17.9122210691
158PhosphorylationLVINDLTYHVRPPKR
EEEEHHHCCCCCCCC
12.9622210691
162UbiquitinationDLTYHVRPPKRDLLS
HHHCCCCCCCCCCCC
37.3629967540
1642-HydroxyisobutyrylationTYHVRPPKRDLLSHE
HCCCCCCCCCCCCCC
62.32-
164UbiquitinationTYHVRPPKRDLLSHE
HCCCCCCCCCCCCCC
62.3229967540
170UbiquitinationPKRDLLSHENAATLN
CCCCCCCCCCCCHHH
32.0923503661
199AcetylationIEQHQLNKERELIER
HHHHHHHHHHHHHHH
67.7425953088
211 (in isoform 1)Ubiquitination-56.5921906983
211SuccinylationIERLEDLKEQLAPLE
HHHHHHHHHHHHCHH
56.5923954790
2112-HydroxyisobutyrylationIERLEDLKEQLAPLE
HHHHHHHHHHHHCHH
56.59-
211AcetylationIERLEDLKEQLAPLE
HHHHHHHHHHHHCHH
56.5926051181
211UbiquitinationIERLEDLKEQLAPLE
HHHHHHHHHHHHCHH
56.5922817900
218UbiquitinationKEQLAPLEKVRIEIS
HHHHHCHHHHHHEEE
48.7422817900
2192-HydroxyisobutyrylationEQLAPLEKVRIEISR
HHHHCHHHHHHEEEH
44.49-
219UbiquitinationEQLAPLEKVRIEISR
HHHHCHHHHHHEEEH
44.4923503661
219AcetylationEQLAPLEKVRIEISR
HHHHCHHHHHHEEEH
44.4923954790
226UbiquitinationKVRIEISRKAEKRTT
HHHHEEEHHHCCCEE
48.1123503661
232PhosphorylationSRKAEKRTTLVLWGG
EHHHCCCEEEEEECH
35.23-
233PhosphorylationRKAEKRTTLVLWGGL
HHHCCCEEEEEECHH
20.92-
267UbiquitinationWDIMEPVTYFITYGS
CCCCCCCEEEEHHHH
24.3529967540
283UbiquitinationMAMYAYFVMTRQEYV
HHHHHHHHHHCCHHC
2.2029967540
289PhosphorylationFVMTRQEYVYPEARD
HHHHCCHHCCCCCCC
9.28-
291PhosphorylationMTRQEYVYPEARDRQ
HHCCHHCCCCCCCCE
8.41-
295UbiquitinationEYVYPEARDRQYLLF
HHCCCCCCCCEEEEE
37.6729967540
299PhosphorylationPEARDRQYLLFFHKG
CCCCCCEEEEEEECC
13.28-
311UbiquitinationHKGAKKSRFDLEKYN
ECCCCCCCCCHHHHH
37.6729967540
316UbiquitinationKSRFDLEKYNQLKDA
CCCCCHHHHHHHHHH
57.7229967540
3162-HydroxyisobutyrylationKSRFDLEKYNQLKDA
CCCCCHHHHHHHHHH
57.72-
316AcetylationKSRFDLEKYNQLKDA
CCCCCHHHHHHHHHH
57.7225825284
321SuccinylationLEKYNQLKDAIAQAE
HHHHHHHHHHHHHHH
35.0423954790
329SulfoxidationDAIAQAEMDLKRLRD
HHHHHHHHHHHHCCC
9.0721406390
332UbiquitinationAQAEMDLKRLRDPLQ
HHHHHHHHHCCCCCC
45.1629967540
332AcetylationAQAEMDLKRLRDPLQ
HHHHHHHHHCCCCCC
45.1623236377
3322-HydroxyisobutyrylationAQAEMDLKRLRDPLQ
HHHHHHHHHCCCCCC
45.16-
332MalonylationAQAEMDLKRLRDPLQ
HHHHHHHHHCCCCCC
45.1626320211
332SuccinylationAQAEMDLKRLRDPLQ
HHHHHHHHHCCCCCC
45.1627452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
57SPhosphorylationKinaseAMPKA1Q13131
PSP
57SPhosphorylationKinaseCAMK2-Uniprot
92SPhosphorylationKinasePKCB ISO2P05771-2
PSP
92SPhosphorylationKinasePKCDQ05655
PSP
92SPhosphorylationKinasePKCEQ02156
PSP
92SPhosphorylationKinaseCAMK2-Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCU_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCU_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MRP1_HUMANABCC1physical
22939629
S38A2_HUMANSLC38A2physical
22939629
ERLN2_HUMANERLIN2physical
22939629

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MCU_HUMAN

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Related Literatures of Post-Translational Modification

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