UniProt ID | MCU_HUMAN | |
---|---|---|
UniProt AC | Q8NE86 | |
Protein Name | Calcium uniporter protein, mitochondrial {ECO:0000303|PubMed:21685886} | |
Gene Name | MCU {ECO:0000303|PubMed:21685886, ECO:0000312|HGNC:HGNC:23526} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 351 | |
Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . |
|
Protein Description | Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. [PubMed: 21685888] | |
Protein Sequence | MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 | Phosphorylation | MAAAAGRSLLLLLSS CCCHHHHHHHHHHHC | 23.58 | 23403867 | |
14 | Phosphorylation | RSLLLLLSSRGGGGG HHHHHHHHCCCCCCC | 20.26 | 23403867 | |
15 | Phosphorylation | SLLLLLSSRGGGGGG HHHHHHHCCCCCCCC | 34.61 | 23403867 | |
57 | Phosphorylation | TVHQRIASWQNLGAV HHHHHHHHHHHCCEE | 27.16 | 23051746 | |
92 | Phosphorylation | VISVRLPSRRERCQF EEEEECCCCHHHCEE | 48.86 | 23051746 | |
115 | Ubiquitination | VGVFLRQLQEEDRGI HHHHHHHHHHHHCCC | 5.82 | 29967540 | |
157 | Phosphorylation | KLVINDLTYHVRPPK EEEEEHHHCCCCCCC | 17.91 | 22210691 | |
158 | Phosphorylation | LVINDLTYHVRPPKR EEEEHHHCCCCCCCC | 12.96 | 22210691 | |
162 | Ubiquitination | DLTYHVRPPKRDLLS HHHCCCCCCCCCCCC | 37.36 | 29967540 | |
164 | 2-Hydroxyisobutyrylation | TYHVRPPKRDLLSHE HCCCCCCCCCCCCCC | 62.32 | - | |
164 | Ubiquitination | TYHVRPPKRDLLSHE HCCCCCCCCCCCCCC | 62.32 | 29967540 | |
170 | Ubiquitination | PKRDLLSHENAATLN CCCCCCCCCCCCHHH | 32.09 | 23503661 | |
199 | Acetylation | IEQHQLNKERELIER HHHHHHHHHHHHHHH | 67.74 | 25953088 | |
211 (in isoform 1) | Ubiquitination | - | 56.59 | 21906983 | |
211 | Succinylation | IERLEDLKEQLAPLE HHHHHHHHHHHHCHH | 56.59 | 23954790 | |
211 | 2-Hydroxyisobutyrylation | IERLEDLKEQLAPLE HHHHHHHHHHHHCHH | 56.59 | - | |
211 | Acetylation | IERLEDLKEQLAPLE HHHHHHHHHHHHCHH | 56.59 | 26051181 | |
211 | Ubiquitination | IERLEDLKEQLAPLE HHHHHHHHHHHHCHH | 56.59 | 22817900 | |
218 | Ubiquitination | KEQLAPLEKVRIEIS HHHHHCHHHHHHEEE | 48.74 | 22817900 | |
219 | 2-Hydroxyisobutyrylation | EQLAPLEKVRIEISR HHHHCHHHHHHEEEH | 44.49 | - | |
219 | Ubiquitination | EQLAPLEKVRIEISR HHHHCHHHHHHEEEH | 44.49 | 23503661 | |
219 | Acetylation | EQLAPLEKVRIEISR HHHHCHHHHHHEEEH | 44.49 | 23954790 | |
226 | Ubiquitination | KVRIEISRKAEKRTT HHHHEEEHHHCCCEE | 48.11 | 23503661 | |
232 | Phosphorylation | SRKAEKRTTLVLWGG EHHHCCCEEEEEECH | 35.23 | - | |
233 | Phosphorylation | RKAEKRTTLVLWGGL HHHCCCEEEEEECHH | 20.92 | - | |
267 | Ubiquitination | WDIMEPVTYFITYGS CCCCCCCEEEEHHHH | 24.35 | 29967540 | |
283 | Ubiquitination | MAMYAYFVMTRQEYV HHHHHHHHHHCCHHC | 2.20 | 29967540 | |
289 | Phosphorylation | FVMTRQEYVYPEARD HHHHCCHHCCCCCCC | 9.28 | - | |
291 | Phosphorylation | MTRQEYVYPEARDRQ HHCCHHCCCCCCCCE | 8.41 | - | |
295 | Ubiquitination | EYVYPEARDRQYLLF HHCCCCCCCCEEEEE | 37.67 | 29967540 | |
299 | Phosphorylation | PEARDRQYLLFFHKG CCCCCCEEEEEEECC | 13.28 | - | |
311 | Ubiquitination | HKGAKKSRFDLEKYN ECCCCCCCCCHHHHH | 37.67 | 29967540 | |
316 | Ubiquitination | KSRFDLEKYNQLKDA CCCCCHHHHHHHHHH | 57.72 | 29967540 | |
316 | 2-Hydroxyisobutyrylation | KSRFDLEKYNQLKDA CCCCCHHHHHHHHHH | 57.72 | - | |
316 | Acetylation | KSRFDLEKYNQLKDA CCCCCHHHHHHHHHH | 57.72 | 25825284 | |
321 | Succinylation | LEKYNQLKDAIAQAE HHHHHHHHHHHHHHH | 35.04 | 23954790 | |
329 | Sulfoxidation | DAIAQAEMDLKRLRD HHHHHHHHHHHHCCC | 9.07 | 21406390 | |
332 | Ubiquitination | AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC | 45.16 | 29967540 | |
332 | Acetylation | AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC | 45.16 | 23236377 | |
332 | 2-Hydroxyisobutyrylation | AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC | 45.16 | - | |
332 | Malonylation | AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC | 45.16 | 26320211 | |
332 | Succinylation | AQAEMDLKRLRDPLQ HHHHHHHHHCCCCCC | 45.16 | 27452117 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
57 | S | Phosphorylation | Kinase | AMPKA1 | Q13131 | PSP |
57 | S | Phosphorylation | Kinase | CAMK2 | - | Uniprot |
92 | S | Phosphorylation | Kinase | PKCB ISO2 | P05771-2 | PSP |
92 | S | Phosphorylation | Kinase | PKCD | Q05655 | PSP |
92 | S | Phosphorylation | Kinase | PKCE | Q02156 | PSP |
92 | S | Phosphorylation | Kinase | CAMK2 | - | Uniprot |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCU_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCU_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
MRP1_HUMAN | ABCC1 | physical | 22939629 | |
S38A2_HUMAN | SLC38A2 | physical | 22939629 | |
ERLN2_HUMAN | ERLIN2 | physical | 22939629 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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