CISD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CISD2_HUMAN
• UniProt AC: Q8N5K1
• Protein Name: CDGSH iron-sulfur domain-containing protein 2
• Gene Name: CISD2
• Organism: Homo sapiens (Human).
• Sequence Length: 135
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mai
• Protein Description: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy..
• Protein Sequence: MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVLESVARIVKV ---CCHHHHHHHHHC	19.54	30001349
19	2-Hydroxyisobutyrylation	VQLPAYLKRLPVPES CHHHHHHHCCCCCCH	38.93	-
19	Ubiquitination	VQLPAYLKRLPVPES CHHHHHHHCCCCCCH	38.93	21890473
34	Phosphorylation	ITGFARLTVSEWLRL HCCCHHCCHHHHHHH	19.21	20068231
36	Phosphorylation	GFARLTVSEWLRLLP CCHHCCHHHHHHHHH	20.16	20068231
67	Ubiquitination	LPKKKQQKDSLINLK CCCCHHCCCCHHCCE	46.95	33845483
67	2-Hydroxyisobutyrylation	LPKKKQQKDSLINLK CCCCHHCCCCHHCCE	46.95	-
69	Phosphorylation	KKKQQKDSLINLKIQ CCHHCCCCHHCCEEC	37.88	27499020
74	Acetylation	KDSLINLKIQKENPK CCCHHCCEECCCCCC	38.31	23236377
74	Ubiquitination	KDSLINLKIQKENPK CCCHHCCEECCCCCC	38.31	33845483
74	2-Hydroxyisobutyrylation	KDSLINLKIQKENPK CCCHHCCEECCCCCC	38.31	-
74	Malonylation	KDSLINLKIQKENPK CCCHHCCEECCCCCC	38.31	26320211
81	Acetylation	KIQKENPKVVNEINI EECCCCCCCCCCCCH	71.09	26051181
81	Ubiquitination	KIQKENPKVVNEINI EECCCCCCCCCCCCH	71.09	33845483
92	Glutathionylation	EINIEDLCLTKAAYC CCCHHHHHHHHHHHH	7.59	22555962
95	Acetylation	IEDLCLTKAAYCRCW HHHHHHHHHHHHHHH	20.33	25953088
95	Ubiquitination	IEDLCLTKAAYCRCW HHHHHHHHHHHHHHH	20.33	21963094
104	Phosphorylation	AYCRCWRSKTFPACD HHHHHHHCCCCCCCC	16.14	23312004
105	Ubiquitination	YCRCWRSKTFPACDG HHHHHHCCCCCCCCC	45.68	33845483
106	Phosphorylation	CRCWRSKTFPACDGS HHHHHCCCCCCCCCC	35.78	26657352
116	Ubiquitination	ACDGSHNKHNELTGD CCCCCCCCCCCCCCC	42.24	33845483
131	2-Hydroxyisobutyrylation	NVGPLILKKKEV--- CCCCEEEEECCC---	55.60	-
131	Ubiquitination	NVGPLILKKKEV--- CCCCEEEEECCC---	55.60	33845483
131	Methylation	NVGPLILKKKEV--- CCCCEEEEECCC---	55.60	-
131	Acetylation	NVGPLILKKKEV--- CCCCEEEEECCC---	55.60	23236377
132	Ubiquitination	VGPLILKKKEV---- CCCEEEEECCC----	51.20	24816145
132	Methylation	VGPLILKKKEV---- CCCEEEEECCC----	51.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CISD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CISD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CISD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	20010695
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• H00854: Wolfram syndrome (WFS); DIDMOAD syndrome
• OMIM Disease
• 604928: Wolfram syndrome 2 (WFS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.