MTX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTX2_HUMAN
• UniProt AC: O75431
• Protein Name: Metaxin-2
• Gene Name: MTX2
• Organism: Homo sapiens (Human).
• Sequence Length: 263
• Subcellular Localization: Mitochondrion outer membrane . Mitochondrion .
• Protein Description: Involved in transport of proteins into the mitochondrion..
• Protein Sequence: MSLVAEAFVSQIAAAEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYFEDRGKGRLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLVAEAFV ------CCHHHHHHH	31.39	25944712
2	Phosphorylation	------MSLVAEAFV ------CCHHHHHHH	31.39	28464451
10	Phosphorylation	LVAEAFVSQIAAAEP HHHHHHHHHHHHCCC	14.93	26074081
23	Phosphorylation	EPWPENATLYQQLKG CCCCCCCCHHHHHCC	37.26	24043423
25	Phosphorylation	WPENATLYQQLKGEQ CCCCCCHHHHHCCCE	7.00	22817900
44	Ubiquitination	DNAASLAVQAFLQMC CHHHHHHHHHHHHHC	5.24	22817900
46	Ubiquitination	AASLAVQAFLQMCNL HHHHHHHHHHHHCCC	10.66	22817900
59	Ubiquitination	NLPIKVVCRANAEYM CCCCEEEEECCCEEC	3.68	22817900
63	Ubiquitination	KVVCRANAEYMSPSG EEEEECCCEECCCCC	14.33	22817900
65	Phosphorylation	VCRANAEYMSPSGKV EEECCCEECCCCCCC	10.65	-
83	Ubiquitination	HVGNQVVSELGPIVQ EECCHHHHHHHHHHH	28.39	22817900
85	Ubiquitination	GNQVVSELGPIVQFV CCHHHHHHHHHHHHH	8.45	21906983
85	Ubiquitination	GNQVVSELGPIVQFV CCHHHHHHHHHHHHH	8.45	22817900
93	Ubiquitination	GPIVQFVKAKGHSLS HHHHHHHHHCCCCCC	45.74	22817900
95	Ubiquitination	IVQFVKAKGHSLSDG HHHHHHHCCCCCCHH	51.98	21906983
98	Ubiquitination	FVKAKGHSLSDGLEE HHHHCCCCCCHHHHH	37.93	22817900
98	Ubiquitination	FVKAKGHSLSDGLEE HHHHCCCCCCHHHHH	37.93	21906983
100	Phosphorylation	KAKGHSLSDGLEEVQ HHCCCCCCHHHHHHH	32.42	-
102	Ubiquitination	KGHSLSDGLEEVQKA CCCCCCHHHHHHHHH	31.45	22817900
108	Ubiquitination	DGLEEVQKAEMKAYM HHHHHHHHHHHHHHH	52.03	22817900
112	Ubiquitination	EVQKAEMKAYMELVN HHHHHHHHHHHHHHH	28.06	22817900
167	Ubiquitination	QKQWEVKRKMKAIGW HHHHHHHHHHHHHCC	49.86	29967540
176	Acetylation	MKAIGWGKKTLDQVL HHHHCCCHHHHHHHH	35.76	25953088
177	Ubiquitination	KAIGWGKKTLDQVLE HHHCCCHHHHHHHHH	50.84	29967540
237	Ubiquitination	DELSEKVKNYSNLLA HHHHHHHHCHHHHHH	62.32	-
237	Acetylation	DELSEKVKNYSNLLA HHHHHHHHCHHHHHH	62.32	26051181
239	Phosphorylation	LSEKVKNYSNLLAFC HHHHHHCHHHHHHHH	8.01	27251275
240	Phosphorylation	SEKVKNYSNLLAFCR HHHHHCHHHHHHHHH	30.32	29507054
253	Phosphorylation	CRRIEQHYFEDRGKG HHHHHHHHHCCCCCC	14.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KASH5_HUMAN	CCDC155	physical	25416956
MIC60_HUMAN	IMMT	physical	26344197
PHB_HUMAN	PHB	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
TPD52_HUMAN	TPD52	physical	26496610
VDAC2_HUMAN	VDAC2	physical	26496610
EI2BD_HUMAN	EIF2B4	physical	26496610
1433T_HUMAN	YWHAQ	physical	26496610
MIC60_HUMAN	IMMT	physical	26496610
PHB2_HUMAN	PHB2	physical	26496610
SAM50_HUMAN	SAMM50	physical	26496610
MIC19_HUMAN	CHCHD3	physical	26496610
MIC25_HUMAN	CHCHD6	physical	26496610
CE120_HUMAN	CEP120	physical	26496610
MTX3_HUMAN	MTX3	physical	28514442
CAR19_HUMAN	C9orf89	physical	28514442
MIC25_HUMAN	CHCHD6	physical	28514442
SAM50_HUMAN	SAMM50	physical	28514442
MIC19_HUMAN	CHCHD3	physical	28514442
MIC60_HUMAN	IMMT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.