| UniProt ID | MTX3_HUMAN | |
|---|---|---|
| UniProt AC | Q5HYI7 | |
| Protein Name | Metaxin-3 | |
| Gene Name | MTX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 312 | |
| Subcellular Localization | Mitochondrion . Mitochondrion outer membrane . | |
| Protein Description | Could function in transport of proteins into the mitochondrion.. | |
| Protein Sequence | MAAPLELSCWGGGWGLPSVHSESLVVMAYAKFSGAPLKVNVIDNTWRGSRGDVPILTTEDDMVSQPAKILNFLRKQKYNADYELSAKQGADTLAYIALLEEKLLPAVLHTFWVESDNYFTVTKPWFASQIPFPLSLILPGRMSKGALNRILLTRGQPPLYHLREVEAQIYRDAKECLNLLSNRLGTSQFFFGDTPSTLDAYVFGFLAPLYKVRFPKVQLQEHLKQLSNLCRFCDDILSSYFRLSLGGISPAGQETVDANLQKLTQLVNKESNLIEKMDDNLRQSPQLPPRKLPTLKLTPAEEENNSFQRLSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Ubiquitination | LSCWGGGWGLPSVHS EEECCCCCCCCCCCC | 14.39 | 23000965 | |
| 16 | Ubiquitination | CWGGGWGLPSVHSES ECCCCCCCCCCCCCH | 2.00 | 23000965 | |
| 38 | Methylation | KFSGAPLKVNVIDNT ECCCCCEEEEEECCC | 30.61 | 115973399 | |
| 38 | Ubiquitination | KFSGAPLKVNVIDNT ECCCCCEEEEEECCC | 30.61 | 32015554 | |
| 68 | Ubiquitination | DMVSQPAKILNFLRK HHHCCHHHHHHHHHH | 55.18 | 29967540 | |
| 75 | Ubiquitination | KILNFLRKQKYNADY HHHHHHHHHCCCCCC | 53.97 | 23000965 | |
| 77 | Ubiquitination | LNFLRKQKYNADYEL HHHHHHHCCCCCCHH | 43.43 | 21890473 | |
| 77 (in isoform 4) | Ubiquitination | - | 43.43 | 21890473 | |
| 77 (in isoform 2) | Ubiquitination | - | 43.43 | 21890473 | |
| 77 (in isoform 1) | Ubiquitination | - | 43.43 | 21890473 | |
| 77 | Ubiquitination | LNFLRKQKYNADYEL HHHHHHHCCCCCCHH | 43.43 | 23000965 | |
| 87 (in isoform 4) | Ubiquitination | - | 45.98 | 21890473 | |
| 87 | Ubiquitination | ADYELSAKQGADTLA CCCHHHHHCCHHHHH | 45.98 | 2190698 | |
| 87 (in isoform 2) | Ubiquitination | - | 45.98 | 21890473 | |
| 87 (in isoform 1) | Ubiquitination | - | 45.98 | 21890473 | |
| 163 | Ubiquitination | QPPLYHLREVEAQIY CCCCCCHHHHHHHHH | 32.38 | 32015554 | |
| 183 (in isoform 5) | Phosphorylation | - | 30.99 | 27251275 | |
| 188 | Phosphorylation | SNRLGTSQFFFGDTP CCCCCCCCCCCCCCH | 38.72 | 32142685 | |
| 188 (in isoform 5) | Phosphorylation | - | 38.72 | 24719451 | |
| 208 | Ubiquitination | YVFGFLAPLYKVRFP HHHHHHHHHHHCCCC | 38.07 | 30230243 | |
| 216 | Acetylation | LYKVRFPKVQLQEHL HHHCCCCHHHHHHHH | 39.64 | 7674153 | |
| 223 | Phosphorylation | KVQLQEHLKQLSNLC HHHHHHHHHHHHHHH | 3.58 | 32142685 | |
| 223 (in isoform 5) | Phosphorylation | - | 3.58 | 24719451 | |
| 224 | Ubiquitination | VQLQEHLKQLSNLCR HHHHHHHHHHHHHHH | 51.61 | 32015554 | |
| 237 (in isoform 5) | Phosphorylation | - | 3.42 | 27251275 | |
| 244 | Phosphorylation | LSSYFRLSLGGISPA HHHHHHHHHCCCCCC | 22.25 | 30266825 | |
| 249 | Phosphorylation | RLSLGGISPAGQETV HHHHCCCCCCCHHHH | 16.39 | 30266825 | |
| 250 (in isoform 5) | Phosphorylation | - | 38.19 | 24719451 | |
| 255 | Phosphorylation | ISPAGQETVDANLQK CCCCCHHHHHHHHHH | 18.79 | 30266825 | |
| 269 | Ubiquitination | KLTQLVNKESNLIEK HHHHHHHHHCCHHHH | 55.85 | 30230243 | |
| 284 | Phosphorylation | MDDNLRQSPQLPPRK HCHHHHHCCCCCCCC | 14.26 | 30266825 | |
| 294 | Phosphorylation | LPPRKLPTLKLTPAE CCCCCCCCCCCCCHH | 47.14 | 21712546 | |
| 298 | Phosphorylation | KLPTLKLTPAEEENN CCCCCCCCCHHHCCC | 20.90 | 25159151 | |
| 306 | Phosphorylation | PAEEENNSFQRLSP- CHHHCCCCCCCCCC- | 34.05 | 23927012 | |
| 311 | Phosphorylation | NNSFQRLSP------ CCCCCCCCC------ | 30.65 | 22167270 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MTX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MTX3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249 AND SER-311, ANDMASS SPECTROMETRY. | |
