| UniProt ID | MIC25_HUMAN | |
|---|---|---|
| UniProt AC | Q9BRQ6 | |
| Protein Name | MICOS complex subunit MIC25 | |
| Gene Name | CHCHD6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 235 | |
| Subcellular Localization |
Mitochondrion inner membrane Lipid-anchor . Mitochondrion . |
|
| Protein Description | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.. | |
| Protein Sequence | MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGSTESSEG ------CCCCCCCCC | - | ||
| 13 | Phosphorylation | SSEGRRVSFGVDEEE CCCCCCCCCCCCHHH | 29255136 | ||
| 31 | Phosphorylation | VLQGVRLSENVVNRM HHHCCCCCHHHHHHC | - | ||
| 42 | Phosphorylation | VNRMKEPSSPPPAPT HHHCCCCCCCCCCCC | 21815630 | ||
| 43 | Phosphorylation | NRMKEPSSPPPAPTS HHCCCCCCCCCCCCC | 25159151 | ||
| 49 | Phosphorylation | SSPPPAPTSSTFGLQ CCCCCCCCCCCCCCC | 30576142 | ||
| 50 | Phosphorylation | SPPPAPTSSTFGLQD CCCCCCCCCCCCCCC | 27732954 | ||
| 51 | Phosphorylation | PPPAPTSSTFGLQDG CCCCCCCCCCCCCCC | 29214152 | ||
| 52 | Phosphorylation | PPAPTSSTFGLQDGN CCCCCCCCCCCCCCC | 28857561 | ||
| 65 | Ubiquitination | GNLRAPHKESTLPRS CCCCCCCCCCCCCCC | 29967540 | ||
| 67 | Phosphorylation | LRAPHKESTLPRSGS CCCCCCCCCCCCCCC | 26074081 | ||
| 68 | Phosphorylation | RAPHKESTLPRSGSS CCCCCCCCCCCCCCC | 26074081 | ||
| 72 | Phosphorylation | KESTLPRSGSSGGQQ CCCCCCCCCCCCCCC | 30576142 | ||
| 74 | Phosphorylation | STLPRSGSSGGQQPS CCCCCCCCCCCCCCC | 25159151 | ||
| 75 | Phosphorylation | TLPRSGSSGGQQPSG CCCCCCCCCCCCCCH | 26074081 | ||
| 81 | Phosphorylation | SSGGQQPSGMKEGVK CCCCCCCCHHHHHHH | 26074081 | ||
| 84 | Acetylation | GQQPSGMKEGVKRYE CCCCCHHHHHHHHHH | 7431215 | ||
| 100 | Acetylation | EHAAIQDKLFQVAKR HHHHHHHHHHHHHHH | 23954790 | ||
| 106 | 2-Hydroxyisobutyrylation | DKLFQVAKREREAAT HHHHHHHHHHHHHHH | - | ||
| 106 | Acetylation | DKLFQVAKREREAAT HHHHHHHHHHHHHHH | 7367267 | ||
| 114 | Ubiquitination | REREAATKHSKASLP HHHHHHHHHCCCCCC | - | ||
| 114 | Acetylation | REREAATKHSKASLP HHHHHHHHHCCCCCC | 7367277 | ||
| 117 | Acetylation | EAATKHSKASLPTGE HHHHHHCCCCCCCCC | 7367287 | ||
| 119 | Phosphorylation | ATKHSKASLPTGEGS HHHHCCCCCCCCCCC | 23312004 | ||
| 122 | Phosphorylation | HSKASLPTGEGSISH HCCCCCCCCCCCCCH | 23312004 | ||
| 126 | Phosphorylation | SLPTGEGSISHEEQK CCCCCCCCCCHHHHH | 28348404 | ||
| 128 | Phosphorylation | PTGEGSISHEEQKSV CCCCCCCCHHHHHHH | 23312004 | ||
| 133 | Malonylation | SISHEEQKSVRLARE CCCHHHHHHHHHHHH | 26320211 | ||
| 133 | Acetylation | SISHEEQKSVRLARE CCCHHHHHHHHHHHH | 23954790 | ||
| 134 | Phosphorylation | ISHEEQKSVRLAREL CCHHHHHHHHHHHHH | 25002506 | ||
| 153 | Phosphorylation | AELRRRDTFYKEQLE HHHHHHHHHHHHHHH | 25884760 | ||
| 155 | Phosphorylation | LRRRDTFYKEQLERI HHHHHHHHHHHHHHH | 23312004 | ||
| 156 | Ubiquitination | RRRDTFYKEQLERIE HHHHHHHHHHHHHHH | 29967540 | ||
| 157 | Ubiquitination | RRDTFYKEQLERIER HHHHHHHHHHHHHHH | 29967540 | ||
| 165 | Acetylation | QLERIERKNAEMYKL HHHHHHHHCHHHHHC | 26051181 | ||
| 170 | Phosphorylation | ERKNAEMYKLSSEQF HHHCHHHHHCCHHHH | - | ||
| 171 | Acetylation | RKNAEMYKLSSEQFH HHCHHHHHCCHHHHH | 26051181 | ||
| 173 | Phosphorylation | NAEMYKLSSEQFHEA CHHHHHCCHHHHHHH | - | ||
| 186 | Phosphorylation | EAASKMESTIKPRRV HHHHHCHHCCCCCCC | 20068231 | ||
| 187 | Ubiquitination | AASKMESTIKPRRVE HHHHCHHCCCCCCCH | 21963094 | ||
| 187 | Phosphorylation | AASKMESTIKPRRVE HHHHCHHCCCCCCCH | 20068231 | ||
| 223 | Ubiquitination | LLCSDLVKAYQRCVS EECHHHHHHHHHHHH | 21963094 | ||
| 223 | Acetylation | LLCSDLVKAYQRCVS EECHHHHHHHHHHHH | 26051181 | ||
| 224 | Ubiquitination | LCSDLVKAYQRCVSA ECHHHHHHHHHHHHH | 21963094 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIC25_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIC25_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIC25_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| ERLN1_HUMAN | ERLIN1 | physical | 22939629 | |
| TMED4_HUMAN | TMED4 | physical | 22939629 | |
| CMC1_HUMAN | SLC25A12 | physical | 22939629 | |
| HACD3_HUMAN | PTPLAD1 | physical | 22939629 | |
| CHCH2_HUMAN | CHCHD2 | physical | 26344197 | |
| NDUA8_HUMAN | NDUFA8 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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