KGUA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KGUA_HUMAN
• UniProt AC: Q16774
• Protein Name: Guanylate kinase
• Gene Name: GUK1
• Organism: Homo sapiens (Human).
• Sequence Length: 197
• Protein Description: Essential for recycling GMP and indirectly, cGMP..
• Protein Sequence: MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGPRPVVL ------CCCCCCEEE	58.46	27067055
2	Acetylation	------MSGPRPVVL ------CCCCCCEEE	58.46	19413330
13	Phosphorylation	PVVLSGPSGAGKSTL CEEECCCCCCCHHHH	44.81	29514088
17	Ubiquitination	SGPSGAGKSTLLKRL CCCCCCCHHHHHHHH	39.47	-
18	Phosphorylation	GPSGAGKSTLLKRLL CCCCCCHHHHHHHHH	24.30	24719451
19	Phosphorylation	PSGAGKSTLLKRLLQ CCCCCHHHHHHHHHH	39.33	29514088
23 (in isoform 3)	Phosphorylation	-	40.37	22210691
23 (in isoform 2)	Phosphorylation	-	40.37	22210691
31 (in isoform 3)	Phosphorylation	-	3.23	22210691
31 (in isoform 2)	Phosphorylation	-	3.23	22210691
51	Ubiquitination	RPGEENGKDYYFVTR CCCCCCCCEEEEEEH	54.89	21890473
53	Phosphorylation	GEENGKDYYFVTREV CCCCCCEEEEEEHHH	11.42	26356563
54	Phosphorylation	EENGKDYYFVTREVM CCCCCEEEEEEHHHH	11.16	26356563
72	Ubiquitination	IAAGDFIEHAEFSGN HHCCCCHHEEEECCC	36.72	21890473
94	Sulfoxidation	AVQAVQAMNRICVLD HHHHHHHHHCEEEEE	1.61	21406390
111	Ubiquitination	LQGVRNIKATDLRPI CCCCCCCCCCCCCCE	49.10	-
139	Phosphorylation	QRLRQRNTETEESLV HHHHHCCCCCHHHHH	46.61	21406692
141	Phosphorylation	LRQRNTETEESLVKR HHHCCCCCHHHHHHH	42.91	21406692
144	Phosphorylation	RNTETEESLVKRLAA CCCCCHHHHHHHHHH	32.03	21406692
147	Ubiquitination	ETEESLVKRLAAAQA CCHHHHHHHHHHHHC	47.16	-
147	Acetylation	ETEESLVKRLAAAQA CCHHHHHHHHHHHHC	47.16	25953088
158	Phosphorylation	AAQADMESSKEPGLF HHHCHHHHCCCCCCC	39.82	-
159	Phosphorylation	AQADMESSKEPGLFD HHCHHHHCCCCCCCE	27.94	-
173	Phosphorylation	DVVIINDSLDQAYAE EEEEECCCHHHHHHH	29.38	-
178	Phosphorylation	NDSLDQAYAELKEAL CCCHHHHHHHHHHHH	8.58	-
190	Acetylation	EALSEEIKKAQRTGA HHHHHHHHHHHHHCC	45.39	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KGUA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KGUA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KGUA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC19_HUMAN	TTC19	physical	26186194
TTC19_HUMAN	TTC19	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.