TAM41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAM41_HUMAN
• UniProt AC: Q96BW9
• Protein Name: Phosphatidate cytidylyltransferase, mitochondrial
• Gene Name: TAMM41
• Organism: Homo sapiens (Human).
• Sequence Length: 452
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity)..
• Protein Sequence: MALQTLQSSWVTFRKILSHFPEELSLAFVYGSGVYRQAGPSSDQKNAMLDFVFTVDDPVAWHSKNLKKNWSHYSFLKVLGPKIITSIQNNYGAGVYYNSLIMCNGRLIKYGVISTNVLIEDLLNWNNLYIAGRLQKPVKIISVNEDVTLRSALDRNLKSAVTAAFLMLPESFSEEDLFIEIAGLSYSGDFRMVVGEDKTKVLNIVKPNIAHFRELYGSILQENPQVVYKSQQGWLEIDKSPEGQFTQLMTLPKTLQQQINHIMDPPGKNRDVEETLFQVAHDPDCGDVVRLGLSAIVRPSSIRQSTKGIFTAGKSFGNPCVTYLLTEWLPHSWLQCKALYLLGACEMLSFDGHKLGYCSKVQTGITAAEPGGRTMSDHWQCCWKLYCPSEFSETLPVCRVFPSYCFIYQSYRCIGLQKQQHLCSPSSSPSLRQLLPSVLVGYFCCYCHFSKW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MALQTLQSSWVT ---CCHHHHHHHHHH	27.84	28270605
8	Phosphorylation	MALQTLQSSWVTFRK CCHHHHHHHHHHHHH	29.31	28270605
9	Phosphorylation	ALQTLQSSWVTFRKI CHHHHHHHHHHHHHH	16.77	28270605
12	Phosphorylation	TLQSSWVTFRKILSH HHHHHHHHHHHHHHC	16.09	28270605
18	Phosphorylation	VTFRKILSHFPEELS HHHHHHHHCCCHHCC	26.93	24719451
35	Phosphorylation	FVYGSGVYRQAGPSS EEECCCCCCCCCCCH	10.67	24719451
41	Phosphorylation	VYRQAGPSSDQKNAM CCCCCCCCHHHCCCE	45.70	24719451
54	Phosphorylation	AMLDFVFTVDDPVAW CEEEEEEEECCHHHH	20.09	-
71	Phosphorylation	KNLKKNWSHYSFLKV CCCCHHHCHHHHHHH	23.18	26657352
73	Phosphorylation	LKKNWSHYSFLKVLG CCHHHCHHHHHHHHC	8.80	26657352
74	Phosphorylation	KKNWSHYSFLKVLGP CHHHCHHHHHHHHCH	20.76	24719451
148	Phosphorylation	ISVNEDVTLRSALDR EEECCCCHHHHHHHH	28.86	24719451
151	Phosphorylation	NEDVTLRSALDRNLK CCCCHHHHHHHHHHH	35.97	26074081
159	Phosphorylation	ALDRNLKSAVTAAFL HHHHHHHHHHHHHHH	31.01	26074081
162	Phosphorylation	RNLKSAVTAAFLMLP HHHHHHHHHHHHHCC	16.40	26074081
171	Phosphorylation	AFLMLPESFSEEDLF HHHHCCCCCCCCCCE	31.94	26074081
173	Phosphorylation	LMLPESFSEEDLFIE HHCCCCCCCCCCEEE	49.72	26074081
299 (in isoform 2)	Phosphorylation	-	7.05	25839225
300 (in isoform 2)	Phosphorylation	-	20.33	30108239
301 (in isoform 2)	Phosphorylation	-	16.74	30108239
320 (in isoform 3)	Phosphorylation	-		25839225
321 (in isoform 3)	Phosphorylation	-		30108239
322 (in isoform 3)	Phosphorylation	-		30108239
424	Phosphorylation	QKQQHLCSPSSSPSL CCCCCCCCCCCCHHH		23663014
426	Phosphorylation	QQHLCSPSSSPSLRQ CCCCCCCCCCHHHHH		23663014
427	Phosphorylation	QHLCSPSSSPSLRQL CCCCCCCCCHHHHHH		23663014
428	Phosphorylation	HLCSPSSSPSLRQLL CCCCCCCCHHHHHHH		23663014
430	Phosphorylation	CSPSSSPSLRQLLPS CCCCCCHHHHHHHHH		23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAM41_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAM41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAM41_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAM41_HUMAN	TAMM41	physical	27499296
G6PI_HUMAN	GPI	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.