TMM70_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM70_HUMAN
• UniProt AC: Q9BUB7
• Protein Name: Transmembrane protein 70, mitochondrial
• Gene Name: TMEM70
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Involved in biogenesis of mitochondrial ATP synthase..
• Protein Sequence: MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LPLCGRRTALCAAAA CCCCCHHHHHHHHHH	23.71	22210691
35	Phosphorylation	ALRGPRASVSRASSS HHHCCCEEECCCCCC	23.16	-
37	Phosphorylation	RGPRASVSRASSSSG HCCCEEECCCCCCCC	21.45	28857561
74	Phosphorylation	GRAQIPVYWEGYVRF CCCCCCEEEEEEEEE	7.74	27642862
84	Phosphorylation	GYVRFLNTPSDKSED EEEEEECCCCCCCCC	26.73	-
86	Phosphorylation	VRFLNTPSDKSEDGR EEEECCCCCCCCCCC	56.48	-
88	Ubiquitination	FLNTPSDKSEDGRLI EECCCCCCCCCCCEE	61.14	21906983
88 (in isoform 1)	Ubiquitination	-	61.14	21890473
89	Phosphorylation	LNTPSDKSEDGRLIY ECCCCCCCCCCCEEE	46.00	24719451
96	Phosphorylation	SEDGRLIYTGNMARA CCCCCEEECCCHHHH	17.12	29496907
102 (in isoform 2)	Ubiquitination	-	22.10	21890473
118 (in isoform 2)	Ubiquitination	-	24.77	21890473
171	Phosphorylation	KGYVIRLYHEATTDT CCCEEEEEEECCCCH	6.43	-
179	Phosphorylation	HEATTDTYKAITYNA EECCCCHHHHHHHHH	10.96	-
184	Phosphorylation	DTYKAITYNAMLAET CHHHHHHHHHHHHCC	8.53	-
201	Ubiquitination	VFHQNDVKIPDAKHV EECCCCCCCCCHHHE	51.92	21906983
201 (in isoform 1)	Ubiquitination	-	51.92	21890473
206	Ubiquitination	DVKIPDAKHVFTTFY CCCCCCHHHEEEEEE	47.91	22817900
206	Malonylation	DVKIPDAKHVFTTFY CCCCCCHHHEEEEEE	47.91	30639696
213	Phosphorylation	KHVFTTFYAKTKSLL HHEEEEEEECCHHHE	12.70	29496907
215	Ubiquitination	VFTTFYAKTKSLLVN EEEEEEECCHHHEEE	45.14	22817900
217	Ubiquitination	TTFYAKTKSLLVNPV EEEEECCHHHEEECE	38.10	27667366
217 (in isoform 1)	Ubiquitination	-	38.10	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM70_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM70_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM70_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACS2L_HUMAN	ACSS1	physical	28514442
CHDH_HUMAN	CHDH	physical	28514442
MIPEP_HUMAN	MIPEP	physical	28514442
SYNM_HUMAN	NARS2	physical	28514442
ZMY19_HUMAN	ZMYND19	physical	28514442
MCCA_HUMAN	MCCC1	physical	28514442
COQ6_HUMAN	COQ6	physical	28514442
CPSM_HUMAN	CPS1	physical	28514442
CPT2_HUMAN	CPT2	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442
ACSF3_HUMAN	ACSF3	physical	28514442
MAEA_HUMAN	MAEA	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• 614052: Mitochondrial complex V deficiency, nuclear 2 (MC5DN2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.