| UniProt ID | ADRO_HUMAN | |
|---|---|---|
| UniProt AC | P22570 | |
| Protein Name | NADPH:adrenodoxin oxidoreductase, mitochondrial | |
| Gene Name | FDXR {ECO:0000312|HGNC:HGNC:3642} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 491 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein . |
|
| Protein Description | Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.. | |
| Protein Sequence | MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVPELREAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 59 | Malonylation | YTAQHLLKHPQAHVD HHHHHHHHCCCCCCC | 60.65 | 26320211 | |
| 90 | Malonylation | APDHPEVKNVINTFT CCCCHHHHHHHHHHH | 43.78 | 26320211 | |
| 169 | Ubiquitination | NGLPENQELEPDLSC CCCCCCCCCCCCCCC | 67.68 | 21890473 | |
| 208 | Phosphorylation | HLERTDITKAALGVL HHCCCCHHHHHHHHH | 19.90 | - | |
| 209 | Ubiquitination | LERTDITKAALGVLR HCCCCHHHHHHHHHH | 31.81 | - | |
| 209 (in isoform 1) | Ubiquitination | - | 31.81 | 21890473 | |
| 209 | Ubiquitination | LERTDITKAALGVLR HCCCCHHHHHHHHHH | 31.81 | 21890473 | |
| 209 | Ubiquitination | LERTDITKAALGVLR HCCCCHHHHHHHHHH | 31.81 | 21890473 | |
| 209 | Malonylation | LERTDITKAALGVLR HCCCCHHHHHHHHHH | 31.81 | 26320211 | |
| 215 (in isoform 2) | Ubiquitination | - | 3.80 | - | |
| 239 | Acetylation | LQVAFTIKELREMIQ HHHEEEHHHHHHHHC | 47.87 | 25038526 | |
| 240 | Ubiquitination | QVAFTIKELREMIQL HHEEEHHHHHHHHCC | 49.57 | 21890473 | |
| 252 | Ubiquitination | IQLPGARPILDPVDF HCCCCCCCCCCHHHH | 30.84 | 21890473 | |
| 252 | Ubiquitination | IQLPGARPILDPVDF HCCCCCCCCCCHHHH | 30.84 | - | |
| 271 (in isoform 2) | Ubiquitination | - | 49.16 | - | |
| 277 | Phosphorylation | PRPRKRLTELLLRTA CCCHHHHHHHHHHHH | 28.72 | - | |
| 283 | Phosphorylation | LTELLLRTATEKPGP HHHHHHHHHCCCCCH | 37.59 | 21406692 | |
| 285 | Phosphorylation | ELLLRTATEKPGPAE HHHHHHHCCCCCHHH | 43.88 | 21406692 | |
| 289 (in isoform 2) | Phosphorylation | - | 45.15 | 21406692 | |
| 310 | Phosphorylation | WGLRFFRSPQQVLPS HCCHHCCCHHHCCCC | 23.15 | 30266825 | |
| 317 | Phosphorylation | SPQQVLPSPDGRRAA CHHHCCCCCCCCCHH | 31.31 | 30266825 | |
| 323 (in isoform 2) | Phosphorylation | - | 13.75 | 24719451 | |
| 340 | Phosphorylation | LEGVDEATRAVPTGD EECCCHHHCCCCCCC | 19.67 | - | |
| 353 | Phosphorylation | GDMEDLPCGLVLSSI CCHHHCCCCEEEEEC | 9.52 | - | |
| 360 | Phosphorylation | CGLVLSSIGYKSRPV CCEEEEECCCCCCCC | 6.67 | 27251275 | |
| 376 | 2-Hydroxyisobutyrylation | PSVPFDSKLGVIPNV CCCCCCCCCCCCCCC | 51.62 | - | |
| 376 | Acetylation | PSVPFDSKLGVIPNV CCCCCCCCCCCCCCC | 51.62 | 25953088 | |
| 382 (in isoform 2) | Ubiquitination | - | 33.09 | - | |
| 419 | Acetylation | TDSFLTGQMLLQDLK CCCHHHHHHHHHHHH | 17.70 | - | |
| 419 | Ubiquitination | TDSFLTGQMLLQDLK CCCHHHHHHHHHHHH | 17.70 | - | |
| 446 | Phosphorylation | AAIQALLSSRGVRPV HHHHHHHHCCCCCCC | 20.88 | 24719451 | |
| 447 | Phosphorylation | AIQALLSSRGVRPVS HHHHHHHCCCCCCCC | 32.78 | 24719451 | |
| 454 | Phosphorylation | SRGVRPVSFSDWEKL CCCCCCCCHHHHHHC | 23.01 | 30266825 | |
| 456 | Phosphorylation | GVRPVSFSDWEKLDA CCCCCCHHHHHHCCH | 34.02 | 30266825 | |
| 460 (in isoform 2) | Phosphorylation | - | 47.62 | - | |
| 462 (in isoform 2) | Phosphorylation | - | 64.10 | - | |
| 497 | Phosphorylation | GH------------- CC------------- | 20068231 | ||
| 499 | Phosphorylation | --------------- --------------- | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ADRO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADRO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADRO_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GSHR_HUMAN | GSR | physical | 26344197 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB03147 | Flavin adenine dinucleotide |
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