COQ6_HUMAN - dbPTM
COQ6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COQ6_HUMAN
UniProt AC Q9Y2Z9
Protein Name Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03193}
Gene Name COQ6 {ECO:0000255|HAMAP-Rule:MF_03193}
Organism Homo sapiens (Human).
Sequence Length 468
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side . Golgi apparatus . Cell projection . Localizes to cell processes and Golgi apparatus in podocytes.
Protein Description FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6..
Protein Sequence MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYDIHFHDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLRTWGLQATNAVSPLKEQIMAFASK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9 (in isoform 3)Phosphorylation-2.9824245541
53UbiquitinationVGAAMACALGYDIHF
HHHHHHHHHCCEEEE		8.4221890473
74AcetylationLLEAGPKKVLEKLSE
EEECCHHHHHHHHHH		56.0130587849
78UbiquitinationGPKKVLEKLSETYSN
CHHHHHHHHHHHHHC		53.8321890473
88PhosphorylationETYSNRVSSISPGSA
HHHHCCCCCCCCCCC		20.79-
319PhosphorylationAMLQYAVSLLKPTKV
HHHHHHHHHHCCCCC		21.5824719451
327PhosphorylationLLKPTKVSARQLPPS
HHCCCCCCHHHCCCC		21.20-
334PhosphorylationSARQLPPSVARVDAK
CHHHCCCCCCCCCCC		26.86-
414PhosphorylationSHLTGYETERQRHNT
HHHCCCHHHHHHHHH		28.16-
421O-linked_GlycosylationTERQRHNTALLAATD
HHHHHHHHHHHHHHH		16.7431492838
4312-HydroxyisobutyrylationLAATDLLKRLYSTSA
HHHHHHHHHHHCCCC		47.88-
434PhosphorylationTDLLKRLYSTSASPL
HHHHHHHHCCCCCHH		17.5920068231
435PhosphorylationDLLKRLYSTSASPLV
HHHHHHHCCCCCHHH		22.0720068231
436PhosphorylationLLKRLYSTSASPLVL
HHHHHHCCCCCHHHH		18.1120068231
437PhosphorylationLKRLYSTSASPLVLL
HHHHHCCCCCHHHHH		22.3220068231
439PhosphorylationRLYSTSASPLVLLRT
HHHCCCCCHHHHHHH		20.6620068231
456PhosphorylationLQATNAVSPLKEQIM
CCCCCCCCCHHHHHH		23.3124719451
459UbiquitinationTNAVSPLKEQIMAFA
CCCCCCHHHHHHHHH		51.46-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COQ6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COQ6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COQ6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZBT16_HUMANZBTB16physical
16169070
A4_HUMANAPPphysical
21832049
COQ3_HUMANCOQ3physical
26344197
COQ5_HUMANCOQ5physical
27499296
COQ6_HUMANCOQ6physical
27499296
NDUF5_HUMANNDUFAF5physical
27499296
DCMC_HUMANMLYCDphysical
27499296
BOLA3_HUMANBOLA3physical
27499296
NRDC_HUMANNRD1physical
27499296
MPPB_HUMANPMPCBphysical
27499296
MPPA_HUMANPMPCAphysical
27499296
CHCH2_HUMANCHCHD2physical
27499296
PDIP2_HUMANPOLDIP2physical
27499296
ECH1_HUMANECH1physical
27499296
CYC_HUMANCYCSphysical
27499296
ATP5E_HUMANATP5Ephysical
27499296
ATPG_HUMANATP5C1physical
27499296
C1QBP_HUMANC1QBPphysical
27499296
NIT2_HUMANNIT2physical
27499296
RM13_HUMANMRPL13physical
27499296
ODBA_HUMANBCKDHAphysical
27499296
ATP5J_HUMANATP5Jphysical
27499296
ETFA_HUMANETFAphysical
27499296
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614650Coenzyme Q10 deficiency, primary, 6 (COQ10D6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COQ6_HUMAN

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Related Literatures of Post-Translational Modification

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