COQ5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COQ5_HUMAN
• UniProt AC: Q5HYK3
• Protein Name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03191}
• Gene Name: COQ5 {ECO:0000255|HAMAP-Rule:MF_03191}
• Organism: Homo sapiens (Human).
• Sequence Length: 327
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)..
• Protein Sequence: MAAPGSCALWSYCGRGWSRAMRGCQLLGLRSSWPGDLLSARLLSQEKRAAETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQHQRKQKRQLRAQQNLSWEEIAKEYQNEEDSLGGSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAAPGSCALWSYC --CCCCCCCCHHHHC	8.65	23663014
11	Phosphorylation	PGSCALWSYCGRGWS CCCCCHHHHCCCCHH	16.05	23663014
12	Phosphorylation	GSCALWSYCGRGWSR CCCCHHHHCCCCHHH	6.32	23663014
14	Ubiquitination	CALWSYCGRGWSRAM CCHHHHCCCCHHHHH	23.93	21890473
39	Phosphorylation	SWPGDLLSARLLSQE CCCHHHHHHHHHCHH	20.74	24719451
58	Phosphorylation	ETHFGFETVSEEEKG HHCCCCEECCHHHCC	27.37	-
60	Phosphorylation	HFGFETVSEEEKGGK CCCCEECCHHHCCCE	46.86	-
69	Phosphorylation	EEKGGKVYQVFESVA HHCCCEEEHHHHHHH	11.49	-
95	Ubiquitination	LGIHRVWKDLLLWKM HCHHHHHHHHHHHHC	35.32	22817900
95	Ubiquitination	LGIHRVWKDLLLWKM HCHHHHHHHHHHHHC	35.32	21890473
95	Ubiquitination	LGIHRVWKDLLLWKM HCHHHHHHHHHHHHC	35.32	21890473
95 (in isoform 1)	Ubiquitination	-	35.32	21890473
95 (in isoform 2)	Ubiquitination	-	35.32	21890473
147	Phosphorylation	LRAQQNLSWEEIAKE HHHHHHCCHHHHHHH	39.74	28857561
153	Ubiquitination	LSWEEIAKEYQNEED CCHHHHHHHHCCCCC	63.72	-
174	Ubiquitination	VVVCDINKEMLKVGK EEEEECCHHHHHHCH	44.85	-
174	Acetylation	VVVCDINKEMLKVGK EEEEECCHHHHHHCH	44.85	26822725
283	Phosphorylation	GDWKSYQYLVESIRR CCHHHHHHHHHHHHC	12.41	25147952

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COQ5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COQ5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COQ5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COQ4_HUMAN	COQ4	physical	25152161
COQ9_HUMAN	COQ9	physical	27499296
COQ5_HUMAN	COQ5	physical	27499296
COQ3_HUMAN	COQ3	physical	27499296
COQ6_HUMAN	COQ6	physical	27499296
COQ7_HUMAN	COQ7	physical	27499296
COQ8A_HUMAN	ADCK3	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
RM18_HUMAN	MRPL18	physical	27499296
CLPX_HUMAN	CLPX	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
SPRY4_HUMAN	SPRYD4	physical	27499296
L2HDH_HUMAN	L2HGDH	physical	27499296
PREY_HUMAN	PYURF	physical	27499296
RT35_HUMAN	MRPS35	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.