COQ7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COQ7_HUMAN
• UniProt AC: Q99807
• Protein Name: 5-demethoxyubiquinone hydroxylase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03194}
• Gene Name: COQ7 {ECO:0000255|HAMAP-Rule:MF_03194}
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner..
• Protein Sequence: MSCAGAAAAPRLWRLRPGARRSLSAYGRRTSVRFRSSGMTLDNISRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLWNVLGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFRDEELEHHDIGLDHDAELAPAYAVLKSIIQAGCRVAIYLSERL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LRPGARRSLSAYGRR CCCCCCHHHHHHCCC	22.56	24719451
26	Phosphorylation	ARRSLSAYGRRTSVR CCHHHHHHCCCCEEE	14.06	24719451
47	Ubiquitination	TLDNISRAAVDRIIR CHHHHHHHHHHHHEE	12.68	21890473
51	Methylation	ISRAAVDRIIRVDHA HHHHHHHHHEECCCC	21.45	-
77	Phosphorylation	QMAVLGRTSVGPVIQ CEEECCCCCCHHHHH	26.43	26437602
78	Phosphorylation	MAVLGRTSVGPVIQK EEECCCCCCHHHHHH	24.58	26437602
85	Ubiquitination	SVGPVIQKMWDQEKD CCHHHHHHHHHHCHH	30.73	21890473
85	Ubiquitination	SVGPVIQKMWDQEKD CCHHHHHHHHHHCHH	30.73	21890473
95	Acetylation	DQEKDHLKKFNELMV HHCHHHHHHHHHHHH	52.48	6567977
96	Acetylation	QEKDHLKKFNELMVT HCHHHHHHHHHHHHH	60.84	30585361
103	Phosphorylation	KFNELMVTFRVRPTV HHHHHHHHEECCCCC	7.55	24719451
135	Ubiquitination	LLGKEGAMACTVAVE HCCCCCCCHHEEEHH	4.65	29967540
138	Phosphorylation	KEGAMACTVAVEESI CCCCCHHEEEHHHHH	11.27	21406692
144	Phosphorylation	CTVAVEESIAHHYNN HEEEHHHHHHHHHHH	16.15	21406692
149	Phosphorylation	EESIAHHYNNQIRTL HHHHHHHHHHHHHHH	13.12	21406692
155	Phosphorylation	HYNNQIRTLMEEDPE HHHHHHHHHHHHCHH	31.89	21406692
173	Ubiquitination	ELLQLIKKFRDEELE HHHHHHHHHCCHHHH	38.34	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COQ7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COQ7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COQ7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COQ7_HUMAN	COQ7	physical	27499296
BOLA3_HUMAN	BOLA3	physical	27499296
NRDC_HUMAN	NRD1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
GLRX5_HUMAN	GLRX5	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
IDE_HUMAN	IDE	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.