COQ8A_HUMAN - dbPTM
COQ8A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COQ8A_HUMAN
UniProt AC Q8NI60
Protein Name Atypical kinase COQ8A, mitochondrial {ECO:0000305}
Gene Name COQ8A {ECO:0000303|PubMed:27499294, ECO:0000312|HGNC:HGNC:16812}
Organism Homo sapiens (Human).
Sequence Length 647
Subcellular Localization Mitochondrion . Membrane
Single-pass membrane protein .
Protein Description Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. [PubMed: 25498144]
Protein Sequence MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKRQAQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
91 (in isoform 2)Ubiquitination-21890473
91 (in isoform 4)Ubiquitination-21890473
135PhosphorylationAGFPGQASSPLGRAN
CCCCCCCCCCCCCCC		25627689
140 (in isoform 2)Ubiquitination-21890473
140 (in isoform 4)Ubiquitination-21890473
155 (in isoform 4)Ubiquitination-21890473
159 (in isoform 4)Ubiquitination-21890473
168PhosphorylationRFFHQDQSPVGGLTA
HHCCCCCCCCCCCCH		26657352
172 (in isoform 4)Ubiquitination-21890473
194 (in isoform 3)Ubiquitination-21890473
198PhosphorylationKQHKQTLSEHARERK
HHHHHHHHHHHHHCC		26437602
236PhosphorylationLAEVAKKSLRSEDPS
HHHHHHHHHCCCCCC		50563671
239PhosphorylationVAKKSLRSEDPSGKK
HHHHHHCCCCCCCCC		50563677
243 (in isoform 3)Ubiquitination-21890473
245UbiquitinationRSEDPSGKKAVLGSS
CCCCCCCCCEECCCC		22817900
246 (in isoform 1)Ubiquitination-21890473
246UbiquitinationSEDPSGKKAVLGSSP
CCCCCCCCEECCCCC		22817900
258 (in isoform 3)Ubiquitination-21890473
262 (in isoform 3)Ubiquitination-21890473
275 (in isoform 3)Ubiquitination-21890473
295 (in isoform 1)Ubiquitination-21890473
295UbiquitinationFINPHLAKIFERVRQ
CCCHHHHHHHHHHHH		21890473
309 (in isoform 2)Ubiquitination-21890473
310 (in isoform 1)Ubiquitination-21890473
310UbiquitinationSADFMPLKQMMKTLN
CCCCCCHHHHHHHHC		21890473
314 (in isoform 1)Ubiquitination-21890473
314UbiquitinationMPLKQMMKTLNNDLG
CCHHHHHHHHCCCCC		21890473
327 (in isoform 1)Ubiquitination-21890473
327UbiquitinationLGPNWRDKLEYFEER
CCCCHHHHHHHHHHC		22817900
408PhosphorylationELALECDYQREAACA
HHHHHCHHHHHHHHH		37817065
487 (in isoform 4)Ubiquitination-21890473
590 (in isoform 3)Ubiquitination-21890473
616PhosphorylationLHRKMGGSFLICSKL
HHHHCCCEEEEECCC		21406692
621PhosphorylationGGSFLICSKLKARFP
CCEEEEECCCHHHCC		21406692
642 (in isoform 1)Ubiquitination-21890473
642UbiquitinationEAYSNYCKRQAQQ--
HHHHHHHHHHHCC--		21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COQ8A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COQ8A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COQ8A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATRAP_HUMANAGTRAPphysical
25416956
TM159_HUMANTMEM159physical
25416956
REEP6_HUMANREEP6physical
25416956
TM239_HUMANTMEM239physical
25416956
COQ5_HUMANCOQ5physical
26344197
COQ8A_HUMANADCK3physical
27499296
COQ3_HUMANCOQ3physical
27499296
COQ5_HUMANCOQ5physical
27499296
COQ7_HUMANCOQ7physical
27499296
COQ6_HUMANCOQ6physical
27499296
CPT2_HUMANCPT2physical
27499296
CHCH2_HUMANCHCHD2physical
27499296
COQ9_HUMANCOQ9physical
27499296
GOLP3_HUMANGOLPH3physical
27499296
MPPB_HUMANPMPCBphysical
27499296
MPPA_HUMANPMPCAphysical
27499296
CLPB_HUMANCLPBphysical
27499296
CX6A1_HUMANCOX6A1physical
27499296
NDUS3_HUMANNDUFS3physical
27499296
TIM44_HUMANTIMM44physical
27499296
RT16_HUMANMRPS16physical
27499296
PDIP2_HUMANPOLDIP2physical
27499296
ATPO_HUMANATP5Ophysical
27499296
ECH1_HUMANECH1physical
27499296
DOK2_HUMANDOK2physical
28514442
G3PT_HUMANGAPDHSphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COQ8A_HUMAN

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Related Literatures of Post-Translational Modification

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