| UniProt ID | COQ9_HUMAN | |
|---|---|---|
| UniProt AC | O75208 | |
| Protein Name | Ubiquinone biosynthesis protein COQ9, mitochondrial | |
| Gene Name | COQ9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 318 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.. | |
| Protein Sequence | MAAAAVSGALGRAGWRLLQLRCLPVARCRQALVPRAFHASAVGLRSSDEQKQQPPNSFSQQHSETQGAEKPDPESSHSPPRYTDQGGEEEEDYESEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MAAAAVSGALGRAG -CHHHHHHHHHHHHH | 17.39 | 21406692 | |
| 59 | Phosphorylation | QQPPNSFSQQHSETQ CCCCCCHHHHHHCCC | 28.84 | 23186163 | |
| 63 | Phosphorylation | NSFSQQHSETQGAEK CCHHHHHHCCCCCCC | 37.69 | 23186163 | |
| 65 | Phosphorylation | FSQQHSETQGAEKPD HHHHHHCCCCCCCCC | 35.00 | 23186163 | |
| 75 | Phosphorylation | AEKPDPESSHSPPRY CCCCCCCCCCCCCCC | 38.45 | 26657352 | |
| 76 | Phosphorylation | EKPDPESSHSPPRYT CCCCCCCCCCCCCCC | 26.73 | 23186163 | |
| 78 | Phosphorylation | PDPESSHSPPRYTDQ CCCCCCCCCCCCCCC | 38.25 | 23917254 | |
| 82 | Phosphorylation | SSHSPPRYTDQGGEE CCCCCCCCCCCCCCC | 22.05 | 21082442 | |
| 93 | Phosphorylation | GGEEEEDYESEEQLQ CCCCCCCCCCHHHHH | 25.32 | 21552520 | |
| 95 | Phosphorylation | EEEEDYESEEQLQHR CCCCCCCCHHHHHHH | 39.96 | - | |
| 166 | Ubiquitination | RVLEEEQKLVQLGQA HHHHHHHHHHHHHHH | 54.64 | - | |
| 175 | Acetylation | VQLGQAEKRKTDQFL HHHHHHHHHCCHHHH | 63.31 | - | |
| 175 | 2-Hydroxyisobutyrylation | VQLGQAEKRKTDQFL HHHHHHHHHCCHHHH | 63.31 | - | |
| 178 | Phosphorylation | GQAEKRKTDQFLRDA HHHHHHCCHHHHHHH | 38.78 | 24043423 | |
| 183 | Methylation | RKTDQFLRDAVETRL HCCHHHHHHHHHHHH | 31.00 | - | |
| 188 | Phosphorylation | FLRDAVETRLRMLIP HHHHHHHHHHHHHHH | 28.53 | 24043423 | |
| 276 | Methylation | TWRFLENRVNDAMNM HHHHHHHHHHHHHHC | 21.17 | - | |
| 286 | Phosphorylation | DAMNMGHTAKQVKST HHHHCCCCHHHHHHH | 29.80 | - | |
| 292 | Phosphorylation | HTAKQVKSTGEALVQ CCHHHHHHHHHHHHH | 42.67 | 20068231 | |
| 293 | Phosphorylation | TAKQVKSTGEALVQG CHHHHHHHHHHHHHH | 33.07 | 20068231 | |
| 307 | Phosphorylation | GLMGAAVTLKNLTGL HHHHHHHHHHHHCCC | 27.56 | 20068231 | |
| 312 | Phosphorylation | AVTLKNLTGLNQRR- HHHHHHHCCCCCCC- | 49.36 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COQ9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COQ9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COQ9_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614654 | Coenzyme Q10 deficiency, primary, 5 (COQ10D5) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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