| UniProt ID | COX15_HUMAN | |
|---|---|---|
| UniProt AC | Q7KZN9 | |
| Protein Name | Cytochrome c oxidase assembly protein COX15 homolog | |
| Gene Name | COX15 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 410 | |
| Subcellular Localization |
Mitochondrion membrane Multi-pass membrane protein . |
|
| Protein Description | May be involved in the biosynthesis of heme A.. | |
| Protein Sequence | MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSLPSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 62 | Phosphorylation | RGTVSLPSKAAERVV CCEECCCHHHHHHHH | 39.97 | 24719451 | |
| 63 | Ubiquitination | GTVSLPSKAAERVVG CEECCCHHHHHHHHC | 50.07 | 21906983 | |
| 63 (in isoform 2) | Ubiquitination | - | 50.07 | 21906983 | |
| 63 (in isoform 1) | Ubiquitination | - | 50.07 | 21906983 | |
| 109 (in isoform 2) | Ubiquitination | - | 49.27 | - | |
| 109 | Ubiquitination | WHLIKEMKPPTSQEE HHHHHCCCCCCCHHH | 49.27 | - | |
| 131 (in isoform 2) | Ubiquitination | - | 44.62 | - | |
| 131 | Ubiquitination | YQQFPEFKILNHDMT HHHCCCCEECCCCCC | 44.62 | - | |
| 177 | Phosphorylation | FWRKGWLSRGMKGRV HHHCCHHHCCHHHHH | 21.93 | 28634120 | |
| 200 | Phosphorylation | FQGLLGWYMVKSGLE HHHHHHHHHHHCCCC | 7.10 | - | |
| 209 | Ubiquitination | VKSGLEEKSDSHDIP HHCCCCCCCCCCCCC | 50.62 | 2190698 | |
| 209 (in isoform 2) | Ubiquitination | - | 50.62 | 21906983 | |
| 209 (in isoform 1) | Ubiquitination | - | 50.62 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COX15_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COX15_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COX15_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00473 | Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency ( | |||||
| OMIM Disease | ||||||
| 615119 | Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2) | |||||
| 256000 | Leigh syndrome (LS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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