KIF1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF1A_HUMAN
• UniProt AC: Q12756
• Protein Name: Kinesin-like protein KIF1A
• Gene Name: KIF1A
• Organism: Homo sapiens (Human).
• Sequence Length: 1690
• Subcellular Localization: Cytoplasm, cytoskeleton . Expressed in distal regions of neurites.
• Protein Description: Motor for anterograde axonal transport of synaptic vesicle precursors..
• Protein Sequence: MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAGASVKVAVRV ---CCCCCEEEEEEE	22.89	23403867
21	Phosphorylation	PFNSREMSRDSKCII CCCCCCCCCCCCEEE	28.34	-
24	Phosphorylation	SREMSRDSKCIIQMS CCCCCCCCCEEEEEC	28.46	-
54	Phosphorylation	PKSFSFDYSYWSHTS CCCCCCCCCCCCCCC	11.14	30576142
61	Phosphorylation	YSYWSHTSPEDINYA CCCCCCCCHHHCCHH	22.37	30576142
67	Phosphorylation	TSPEDINYASQKQVY CCHHHCCHHHHHHHH	14.15	26074081
69	Phosphorylation	PEDINYASQKQVYRD HHHCCHHHHHHHHHH	27.79	26074081
74	Phosphorylation	YASQKQVYRDIGEEM HHHHHHHHHHHHHHH	10.48	26074081
89	Phosphorylation	LQHAFEGYNVCIFAY HHHHHCCCCEEEEEE	9.38	24144214
96	Phosphorylation	YNVCIFAYGQTGAGK CCEEEEEECCCCCCC	10.06	24144214
99	Phosphorylation	CIFAYGQTGAGKSYT EEEEECCCCCCCCCC	25.33	24144214
133	Phosphorylation	LFSRINDTTNDNMSY HHHHHCCCCCCCCCE	24.02	24043423
134	Phosphorylation	FSRINDTTNDNMSYS HHHHCCCCCCCCCEE	43.36	24043423
139	Phosphorylation	DTTNDNMSYSVEVSY CCCCCCCCEEEEEEE	22.10	24043423
140	Phosphorylation	TTNDNMSYSVEVSYM CCCCCCCEEEEEEEE	13.13	24043423
141	Phosphorylation	TNDNMSYSVEVSYME CCCCCCEEEEEEEEE	12.42	24043423
145	Phosphorylation	MSYSVEVSYMEIYCE CCEEEEEEEEEEHHH	12.78	24043423
146	Phosphorylation	SYSVEVSYMEIYCER CEEEEEEEEEEHHHH	12.16	24043423
150	Phosphorylation	EVSYMEIYCERVRDL EEEEEEEHHHHHHHH	3.80	24043423
201	Ubiquitination	DLMDSGNKARTVAAT HHHHCCCHHCEEEEE	42.65	-
201 (in isoform 2)	Ubiquitination	-	42.65	-
228	Ubiquitination	FNIIFTQKRHDAETN EEEEEEECCCCCCCC	48.95	-
243	Ubiquitination	ITTEKVSKISLVDLA CCCCEECEEEEEECC	39.02	-
266	Ubiquitination	GAKGTRLKEGANINK CCCCCCCCCCCCCCH	51.30	-
274	Phosphorylation	EGANINKSLTTLGKV CCCCCCHHHHHHHHH	26.85	-
276	Phosphorylation	ANINKSLTTLGKVIS CCCCHHHHHHHHHHH	27.37	-
277	Phosphorylation	NINKSLTTLGKVISA CCCHHHHHHHHHHHH	38.51	-
290	Phosphorylation	SALAEMDSGPNKNKK HHHHHCCCCCCCCCC	55.64	-
301	Phosphorylation	KNKKKKKTDFIPYRD CCCCCCCCCCCCHHH	45.05	28555341
325	Phosphorylation	NLGGNSRTAMVAALS CCCCCCCHHHEEECC	20.94	27067055
332	Phosphorylation	TAMVAALSPADINYD HHHEEECCHHHCCHH	17.20	27067055
338	Phosphorylation	LSPADINYDETLSTL CCHHHCCHHHHHHHH	18.58	27067055
373	Ubiquitination	NKLIRELKDEVTRLR CHHHHHHHHHHHHHH	47.27	-
402	Phosphorylation	TNALVGMSPSSSLSA HHHHHCCCCCHHHHH	18.72	24719451
416	Phosphorylation	ALSSRAASVSSLHER HHHHHCCCHHHHHHH	22.88	23911959
418	Phosphorylation	SSRAASVSSLHERIL HHHCCCHHHHHHHHH	25.37	21406692
419	Phosphorylation	SRAASVSSLHERILF HHCCCHHHHHHHHHC	31.43	23911959
425 (in isoform 3)	Phosphorylation	-	3.62	27251275
428 (in isoform 3)	Phosphorylation	-	39.24	27251275
430	Phosphorylation	RILFAPGSEEAIERL HHHCCCCCHHHHHHH	31.07	27732954
458	Phosphorylation	WEEKLRRTEAIRMER HHHHHHHHHHHHHHH	24.28	21406692
482	Phosphorylation	AMREDGGTLGVFSPK EEECCCCEEEECCCC	26.35	25159151
487	Phosphorylation	GGTLGVFSPKKTPHL CCEEEECCCCCCCCC	33.14	25159151
512	Ubiquitination	ECLLYYIKDGITRVG HHHHHHHHHCCCEEC	33.51	-
548	Methylation	CVFRSDSRGGSEAVV EEEEECCCCCCEEEE	59.49	115481141
573	Phosphorylation	YVNGKKVTEPSILRS EECCEECCCCHHHCC	51.57	24961811
607	Phosphorylation	ARQERERTPCAETPA HHHHHHCCCCCCCCC	20.26	-
612	Phosphorylation	ERTPCAETPAEPVDW HCCCCCCCCCCCCCH	14.85	-
669	Phosphorylation	QQRLDYESKLEALQK HHCCCHHHHHHHHHH	35.99	27174698
670	Ubiquitination	QRLDYESKLEALQKQ HCCCHHHHHHHHHHH	38.11	2189047
670 (in isoform 1)	Ubiquitination	-	38.11	21890473
676	Ubiquitination	SKLEALQKQMDSRYY HHHHHHHHHHHHCCC	48.73	-
676 (in isoform 2)	Phosphorylation	-	48.73	27642862
679	Ubiquitination	EALQKQMDSRYYPEV HHHHHHHHHCCCCCC	27.71	21890473
679 (in isoform 2)	Ubiquitination	-	27.71	21890473
680	Phosphorylation	ALQKQMDSRYYPEVN HHHHHHHHCCCCCCC	19.48	27174698
682	Phosphorylation	QKQMDSRYYPEVNEE HHHHHHCCCCCCCCC	27.59	18083107
683	Phosphorylation	KQMDSRYYPEVNEEE HHHHHCCCCCCCCCC	7.57	18083107
685 (in isoform 2)	Ubiquitination	-	41.68	-
744	Ubiquitination	NAISVELKKKVQFQF CCEEEEEHHHCCEEE	36.72	-
793	Ubiquitination	AVEVQDQKNGATHYW EEEEECCCCCCEEEE	66.68	-
804	Acetylation	THYWTLEKLRQRLDL EEEECHHHHHHHHHH	52.67	19820159
825	Phosphorylation	RAAEVPSSVIEDCDN HHCCCCCHHHCCCCC	22.50	-
835	Phosphorylation	EDCDNVVTGGDPFYD CCCCCCCCCCCCHHH	31.03	-
841	Phosphorylation	VTGGDPFYDRFPWFR CCCCCCHHHCCHHHH	16.17	-
850 (in isoform 2)	Phosphorylation	-	4.20	27642862
869	Methylation	YPVPLVHRVAIVSEK CCCCEEEEEEEEECC	16.45	115481133
869 (in isoform 2)	Phosphorylation	-	16.45	27251275
869 (in isoform 3)	Phosphorylation	-	16.45	27251275
876	Ubiquitination	RVAIVSEKGEVKGFL EEEEEECCCCHHHHH	53.52	22053931
880	Ubiquitination	VSEKGEVKGFLRVAV EECCCCHHHHHHHHH	39.38	-
910	Ubiquitination	VRQSGTAKISFDDQH CCCCCEEEEECCHHH	38.43	22053931
920	Ubiquitination	FDDQHFEKFQSESCP CCHHHHHHHCCCCCC	48.00	-
932	Phosphorylation	SCPVVGMSRSGTSQE CCCEECCCCCCCCHH	19.84	27732954
934	Phosphorylation	PVVGMSRSGTSQEEL CEECCCCCCCCHHHE	38.83	28857561
936	Phosphorylation	VGMSRSGTSQEELRI ECCCCCCCCHHHEEE	28.60	28857561
937	Phosphorylation	GMSRSGTSQEELRIV CCCCCCCCHHHEEEE	38.84	27499020
1001	Phosphorylation	LRLGNTFTFRVTVLQ HHCCCEEEEEEEEEE	14.43	-
1011 (in isoform 2)	Ubiquitination	-	24.47	-
1033 (in isoform 3)	Phosphorylation	-	9.75	27251275
1039	Ubiquitination	AFSTEPLKNTGRGPP CCCCCCCCCCCCCCC	64.28	22053931
1094	Phosphorylation	PLCKDVLSPLRPSRR CHHHHHCCCCCCCCC	23.03	26846344
1099	Phosphorylation	VLSPLRPSRRHFPRV HCCCCCCCCCCCCCC	35.20	21406692
1116	Phosphorylation	LSKPVPATKLSTLTR CCCCCCCCCCCCCCC	26.84	26074081
1119	Phosphorylation	PVPATKLSTLTRPCP CCCCCCCCCCCCCCC	23.95	26074081
1120	Phosphorylation	VPATKLSTLTRPCPG CCCCCCCCCCCCCCC	42.45	26074081
1122	Phosphorylation	ATKLSTLTRPCPGPC CCCCCCCCCCCCCCC	32.43	26074081
1140 (in isoform 2)	Ubiquitination	-	29.10	-
1195 (in isoform 3)	Phosphorylation	-	32.40	27251275
1258	Phosphorylation	SLLLNRVTPYREKIY HHHHCCCCCCHHHHH	16.03	25693802
1260	Phosphorylation	LLNRVTPYREKIYMT HHCCCCCCHHHHHHH	23.26	25693802
1265	Phosphorylation	TPYREKIYMTLSAYI CCCHHHHHHHHHHHH	8.63	25693802
1267	Phosphorylation	YREKIYMTLSAYIEM CHHHHHHHHHHHHCC	10.69	25693802
1269	Phosphorylation	EKIYMTLSAYIEMEN HHHHHHHHHHHCCCC	15.17	25693802
1271	Phosphorylation	IYMTLSAYIEMENCT HHHHHHHHHCCCCCC	8.27	25693802
1278	Phosphorylation	YIEMENCTQPAVVTK HHCCCCCCCCEEEEC	49.52	25693802
1284	Phosphorylation	CTQPAVVTKDFCMVF CCCCEEEECCEEEEE	20.49	25693802
1303	Phosphorylation	AKLPASRSIRNLFGS CCCCCCHHHHHHHCC	24.33	22210691
1310	Phosphorylation	SIRNLFGSGSLRASE HHHHHHCCCCCCCCC	20.20	21406692
1312	Phosphorylation	RNLFGSGSLRASESN HHHHCCCCCCCCCCC	19.17	22617229
1316	Phosphorylation	GSGSLRASESNRVTG CCCCCCCCCCCCCCE	34.81	21406692
1318	Phosphorylation	GSLRASESNRVTGVY CCCCCCCCCCCCEEE	27.69	21406692
1322	Phosphorylation	ASESNRVTGVYELSL CCCCCCCCEEEEEEE	20.07	21406692
1325	Phosphorylation	SNRVTGVYELSLCHV CCCCCEEEEEEEEEH	16.70	29978859
1328	Phosphorylation	VTGVYELSLCHVADA CCEEEEEEEEEHHCC	19.60	29978859
1337	Phosphorylation	CHVADAGSPGMQRRR EEHHCCCCCCHHHHH	21.72	27362937
1343 (in isoform 2)	Phosphorylation	-	21.40	29978859
1344 (in isoform 2)	Methylation	-	32.71	-
1368	Phosphorylation	LAGWRPRSDSLILDH CCCCCCCCCCEEECC	33.94	30266825
1370	Phosphorylation	GWRPRSDSLILDHQW CCCCCCCCEEECCHH	20.68	30266825
1390	Ubiquitination	SLLQEVEKTRHYLLL HHHHHHHHHHHHHHH	56.91	-
1413	Phosphorylation	RPVPEALSPAFSEDS CCCCHHHCCCCCCCC	22.64	25921289
1420	Phosphorylation	SPAFSEDSESHGSSS CCCCCCCCCCCCCCC	36.63	25921289
1426	Phosphorylation	DSESHGSSSASSPLS CCCCCCCCCCCCCCC	34.22	23898821
1429	Phosphorylation	SHGSSSASSPLSAEG CCCCCCCCCCCCCCC	34.14	25921289
1430	Phosphorylation	HGSSSASSPLSAEGR CCCCCCCCCCCCCCC	29.58	25921289
1438 (in isoform 3)	Phosphorylation	-	51.67	27251275
1454	Ubiquitination	RQRELAVKCLRLLTH HHHHHHHHHHHHHHH	23.19	-
1463 (in isoform 2)	Phosphorylation	-	6.69	27642862
1467	Phosphorylation	THTFNREYTHSHVCV HHHCCCCCCCCEEEE	13.40	24043423
1468	Phosphorylation	HTFNREYTHSHVCVS HHCCCCCCCCEEEEE	16.49	24043423
1470	Phosphorylation	FNREYTHSHVCVSAS CCCCCCCCEEEEECC	15.15	24043423
1471 (in isoform 3)	Phosphorylation	-	14.91	27251275
1475	Phosphorylation	THSHVCVSASESKLS CCCEEEEECCHHHHC	22.43	24117733
1477	Phosphorylation	SHVCVSASESKLSEM CEEEEECCHHHHCCC	34.59	24117733
1479	Phosphorylation	VCVSASESKLSEMSV EEEECCHHHHCCCEE	36.08	24117733
1482	Phosphorylation	SASESKLSEMSVTLL ECCHHHHCCCEEEEC	34.68	20068231
1485	Phosphorylation	ESKLSEMSVTLLRDP HHHHCCCEEEECCCC	14.11	20068231
1487	Phosphorylation	KLSEMSVTLLRDPSM HHCCCEEEECCCCCC	16.87	21406692
1490	Dimethylation	EMSVTLLRDPSMSPL CCEEEECCCCCCCCC	57.83	-
1490	Methylation	EMSVTLLRDPSMSPL CCEEEECCCCCCCCC	57.83	24412489
1495	Phosphorylation	LLRDPSMSPLGVATL ECCCCCCCCCEEEEE	22.70	24719451
1505	Phosphorylation	GVATLTPSSTCPSLV EEEEECCCCCCHHHH	32.80	27251275
1506	Phosphorylation	VATLTPSSTCPSLVE EEEECCCCCCHHHHC	34.92	27251275
1507	Phosphorylation	ATLTPSSTCPSLVEG EEECCCCCCHHHHCC	32.54	27251275
1516	Phosphorylation	PSLVEGRYGATDLRT HHHHCCCCCCCCCCC	23.20	21406692
1519	Phosphorylation	VEGRYGATDLRTPQP HCCCCCCCCCCCCCC	31.07	21406692
1523	Phosphorylation	YGATDLRTPQPCSRP CCCCCCCCCCCCCCC	33.31	22617229
1528	Phosphorylation	LRTPQPCSRPASPEP CCCCCCCCCCCCCCC	48.24	19664994
1532	Phosphorylation	QPCSRPASPEPELLP CCCCCCCCCCCCCCC	32.26	19664994
1543	Phosphorylation	ELLPEADSKKLPSPA CCCCCCHHCCCCCCC	38.44	21406692
1548	Phosphorylation	ADSKKLPSPARATET CHHCCCCCCCCCCCC	41.44	30266825
1553	Phosphorylation	LPSPARATETDKEPQ CCCCCCCCCCCCCCC	33.59	-
1555	Phosphorylation	SPARATETDKEPQRL CCCCCCCCCCCCCCC	48.28	-
1573	Phosphorylation	DIQEIRVSPIVSKKG CHHEEEEECCCCCCC	10.08	24719451
1577	Phosphorylation	IRVSPIVSKKGYLHF EEEECCCCCCCEEEE	29.39	-
1578 (in isoform 3)	Phosphorylation	-	39.05	27251275
1605	Phosphorylation	VVRRPYAYMYNSDKD EEECCEEECCCCCHH	8.35	-
1607	Phosphorylation	RRPYAYMYNSDKDTV ECCEEECCCCCHHHH	9.99	-
1608 (in isoform 3)	Phosphorylation	-	27.48	27251275
1629 (in isoform 3)	Phosphorylation	-	22.61	27251275
1633 (in isoform 3)	Phosphorylation	-	40.85	27251275
1685	Phosphorylation	SKLSRRRSAQMRV-- HHHHHHHHHHCCC--	22.50	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	24722188
RIMB1_HUMAN	BZRAP1	physical	24722188
ATL4_HUMAN	ADAMTSL4	physical	24722188
FXR2_HUMAN	FXR2	physical	24722188
MDFI_HUMAN	MDFI	physical	24722188
TRIM1_HUMAN	MID2	physical	24722188
MKRN3_HUMAN	MKRN3	physical	24722188
MTUS2_HUMAN	MTUS2	physical	24722188
NT2NL_HUMAN	NOTCH2NL	physical	24722188
PLS1_HUMAN	PLSCR1	physical	24722188
PSA3_HUMAN	PSMA3	physical	24722188
RBPMS_HUMAN	RBPMS	physical	24722188
RFX6_HUMAN	RFX6	physical	24722188
RGS20_HUMAN	RGS20	physical	24722188
RNF31_HUMAN	RNF31	physical	24722188
SPY2_HUMAN	SPRY2	physical	24722188
TNS2_HUMAN	TENC1	physical	24722188
TRAF1_HUMAN	TRAF1	physical	24722188
TRI27_HUMAN	TRIM27	physical	24722188
TRIP6_HUMAN	TRIP6	physical	24722188
KINH_HUMAN	KIF5B	physical	26344197
JIP3_HUMAN	MAPK8IP3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610357: Spastic paraplegia 30, autosomal recessive (SPG30)
• 614213: Neuropathy, hereditary sensory, 2C (HSN2C)
• 614255: Mental retardation, autosomal dominant 9 (MRD9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.