dbPTM

PUR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUR2_HUMAN
UniProt AC	P22102
Protein Name	Trifunctional purine biosynthetic protein adenosine-3
Gene Name	GART
Organism	Homo sapiens (Human).
Sequence Length	1010
Subcellular Localization
Protein Description
Protein Sequence	MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKDVGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPHLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKNLIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAARVLIIG ------CCEEEEEEC	18.45	19413330
10	Phosphorylation	ARVLIIGSGGREHTL EEEEEECCCCHHHHH	27.89	30108239
13	Methylation	LIIGSGGREHTLAWK EEECCCCHHHHHHHH	35.73	-
16	Phosphorylation	GSGGREHTLAWKLAQ CCCCHHHHHHHHHHH	17.26	28857561
20	Methylation	REHTLAWKLAQSHHV HHHHHHHHHHHCCCC	28.47	-
20	Ubiquitination	REHTLAWKLAQSHHV HHHHHHHHHHHCCCC	28.47	-
28	Acetylation	LAQSHHVKQVLVAPG HHHCCCCEEEEECCC	30.27	23749302
28	Ubiquitination	LAQSHHVKQVLVAPG HHHCCCCEEEEECCC	30.27	-
41	S-nitrosylation	PGNAGTACSEKISNT CCCCCHHCCHHHHCC	5.61	22178444
42	Phosphorylation	GNAGTACSEKISNTA CCCCHHCCHHHHCCC	39.19	21712546
44	Acetylation	AGTACSEKISNTAIS CCHHCCHHHHCCCEE	34.83	25953088
44	Ubiquitination	AGTACSEKISNTAIS CCHHCCHHHHCCCEE	34.83	-
62	Glutathionylation	HTALAQFCKEKKIEF HHHHHHHHHHCCCEE	3.56	22555962
63	Ubiquitination	TALAQFCKEKKIEFV HHHHHHHHHCCCEEE	74.07	-
65	Ubiquitination	LAQFCKEKKIEFVVV HHHHHHHCCCEEEEE	44.54	-
66	Acetylation	AQFCKEKKIEFVVVG HHHHHHCCCEEEEEC	48.86	26051181
66	Ubiquitination	AQFCKEKKIEFVVVG HHHHHHCCCEEEEEC	48.86	21906983
66 (in isoform 1)	Ubiquitination	-	48.86	21890473
66 (in isoform 2)	Ubiquitination	-	48.86	21906983
93	Glutathionylation	LRSAGVQCFGPTAEA HHHCCCCEECCHHHH	3.85	22555962
93	S-nitrosylation	LRSAGVQCFGPTAEA HHHCCCCEECCHHHH	3.85	2212679
97	Phosphorylation	GVQCFGPTAEAAQLE CCCEECCHHHHHHHH	37.19	28857561
105	Phosphorylation	AEAAQLESSKRFAKE HHHHHHHHHHHHHHH	50.15	28857561
106	Phosphorylation	EAAQLESSKRFAKEF HHHHHHHHHHHHHHH	20.62	24719451
107	Acetylation	AAQLESSKRFAKEFM HHHHHHHHHHHHHHH	61.90	26051181
107	Ubiquitination	AAQLESSKRFAKEFM HHHHHHHHHHHHHHH	61.90	21906983
107 (in isoform 1)	Ubiquitination	-	61.90	21890473
107 (in isoform 2)	Ubiquitination	-	61.90	21906983
111	Acetylation	ESSKRFAKEFMDRHG HHHHHHHHHHHHHHC	49.09	26822725
111	Ubiquitination	ESSKRFAKEFMDRHG HHHHHHHHHHHHHHC	49.09	21906983
111 (in isoform 1)	Ubiquitination	-	49.09	21890473
111 (in isoform 2)	Ubiquitination	-	49.09	21906983
116	Methylation	FAKEFMDRHGIPTAQ HHHHHHHHHCCCHHH	20.39	-
121	Phosphorylation	MDRHGIPTAQWKAFT HHHHCCCHHHHEEEC	29.56	20068231
125	Methylation	GIPTAQWKAFTKPEE CCCHHHHEEECCHHH	22.88	-
125	Ubiquitination	GIPTAQWKAFTKPEE CCCHHHHEEECCHHH	22.88	-
129	Ubiquitination	AQWKAFTKPEEACSF HHHEEECCHHHHHHH	43.93	-
134	Glutathionylation	FTKPEEACSFILSAD ECCHHHHHHHHHCCC	3.74	22555962
148	Ubiquitination	DFPALVVKASGLAAG CCCEEEEECCCCCCC	29.38	-
156	2-Hydroxyisobutyrylation	ASGLAAGKGVIVAKS CCCCCCCCCEEEECC	45.32	-
156	Acetylation	ASGLAAGKGVIVAKS CCCCCCCCCEEEECC	45.32	26051181
156	Malonylation	ASGLAAGKGVIVAKS CCCCCCCCCEEEECC	45.32	26320211
156	Ubiquitination	ASGLAAGKGVIVAKS CCCCCCCCCEEEECC	45.32	-
156 (in isoform 1)	Ubiquitination	-	45.32	21890473
156 (in isoform 2)	Ubiquitination	-	45.32	21906983
162	Acetylation	GKGVIVAKSKEEACK CCCEEEECCHHHHHH	51.68	25953088
162	Ubiquitination	GKGVIVAKSKEEACK CCCEEEECCHHHHHH	51.68	-
164	Acetylation	GVIVAKSKEEACKAV CEEEECCHHHHHHHH	59.89	25953088
168	Glutathionylation	AKSKEEACKAVQEIM ECCHHHHHHHHHHHH	3.08	22555962
169	Acetylation	KSKEEACKAVQEIMQ CCHHHHHHHHHHHHH	59.65	25953088
169	Ubiquitination	KSKEEACKAVQEIMQ CCHHHHHHHHHHHHH	59.65	-
175	Sulfoxidation	CKAVQEIMQEKAFGA HHHHHHHHHHHCCCC	4.07	30846556
212	Sulfoxidation	DGKTVAPMPPAQDHK CCCEECCCCCHHHCC	4.47	30846556
219	2-Hydroxyisobutyrylation	MPPAQDHKRLLEGDG CCCHHHCCHHHCCCC	53.70	-
219	Acetylation	MPPAQDHKRLLEGDG CCCHHHCCHHHCCCC	53.70	30588885
219	Ubiquitination	MPPAQDHKRLLEGDG CCCHHHCCHHHCCCC	53.70	21906983
219 (in isoform 1)	Ubiquitination	-	53.70	21890473
219 (in isoform 2)	Ubiquitination	-	53.70	21906983
230	Phosphorylation	EGDGGPNTGGMGAYC CCCCCCCCCCCCCCC	37.94	20860994
237	Glutathionylation	TGGMGAYCPAPQVSN CCCCCCCCCCCCCCC	1.99	22555962
249	Acetylation	VSNDLLLKIKDTVLQ CCCCHHHHHHHHHHH	47.91	26051181
249	Ubiquitination	VSNDLLLKIKDTVLQ CCCCHHHHHHHHHHH	47.91	-
251	2-Hydroxyisobutyrylation	NDLLLKIKDTVLQRT CCHHHHHHHHHHHHH	45.84	-
251	Ubiquitination	NDLLLKIKDTVLQRT CCHHHHHHHHHHHHH	45.84	21906983
251 (in isoform 1)	Ubiquitination	-	45.84	21890473
251 (in isoform 2)	Ubiquitination	-	45.84	21906983
258	Phosphorylation	KDTVLQRTVDGMQQE HHHHHHHHHCCCCCC	15.24	24043423
267	Phosphorylation	DGMQQEGTPYTGILY CCCCCCCCCCCCEEE	16.63	24043423
269	Phosphorylation	MQQEGTPYTGILYAG CCCCCCCCCCEEEEE	19.89	24043423
270	Phosphorylation	QQEGTPYTGILYAGI CCCCCCCCCEEEEEE	20.96	24043423
274	Phosphorylation	TPYTGILYAGIMLTK CCCCCEEEEEEEEEC	10.81	24043423
280	Phosphorylation	LYAGIMLTKNGPKVL EEEEEEEECCCCEEE	12.70	24043423
281	Ubiquitination	YAGIMLTKNGPKVLE EEEEEEECCCCEEEE	56.81	21906983
281 (in isoform 1)	Ubiquitination	-	56.81	21890473
281 (in isoform 2)	Ubiquitination	-	56.81	21906983
285	Acetylation	MLTKNGPKVLEFNCR EEECCCCEEEEEECC	61.93	27452117
285	Ubiquitination	MLTKNGPKVLEFNCR EEECCCCEEEEEECC	61.93	-
298	S-nitrosocysteine	CRFGDPECQVILPLL CCCCCCCCCHHHHHH	4.82	-
298	Glutathionylation	CRFGDPECQVILPLL CCCCCCCCCHHHHHH	4.82	22555962
298	S-nitrosylation	CRFGDPECQVILPLL CCCCCCCCCHHHHHH	4.82	19483679
298	S-palmitoylation	CRFGDPECQVILPLL CCCCCCCCCHHHHHH	4.82	26865113
341	Phosphorylation	ALTVVMASKGYPGDY EEEEEEECCCCCCCC	14.44	26074081
344	Phosphorylation	VVMASKGYPGDYTKG EEEECCCCCCCCCCC	14.05	26356563
348	Phosphorylation	SKGYPGDYTKGVEIT CCCCCCCCCCCEEEC	19.10	27155012
349	Phosphorylation	KGYPGDYTKGVEITG CCCCCCCCCCEEECC	26.51	28152594
350	Acetylation	GYPGDYTKGVEITGF CCCCCCCCCEEECCC	55.52	19608861
350	Ubiquitination	GYPGDYTKGVEITGF CCCCCCCCCEEECCC	55.52	19608861
350 (in isoform 1)	Ubiquitination	-	55.52	21890473
350 (in isoform 2)	Ubiquitination	-	55.52	21906983
355	Phosphorylation	YTKGVEITGFPEAQA CCCCEEECCCHHHHH	21.18	26074081
375	Acetylation	FHAGTALKNGKVVTH EECCCEEECCEEEEE	62.28	25953088
375	Ubiquitination	FHAGTALKNGKVVTH EECCCEEECCEEEEE	62.28	21906983
375 (in isoform 1)	Ubiquitination	-	62.28	21890473
375 (in isoform 2)	Ubiquitination	-	62.28	21906983
378	Ubiquitination	GTALKNGKVVTHGGR CCEEECCEEEEECCE	42.81	21906983
378 (in isoform 1)	Ubiquitination	-	42.81	21890473
378 (in isoform 2)	Ubiquitination	-	42.81	21906983
381	Phosphorylation	LKNGKVVTHGGRVLA EECCEEEEECCEEEE	20.14	21949786
390	Phosphorylation	GGRVLAVTAIRENLI CCEEEEHHHHHHHHH	15.68	20068231
398	Phosphorylation	AIRENLISALEEAKK HHHHHHHHHHHHHHH	29.93	21712546
404	Acetylation	ISALEEAKKGLAAIK HHHHHHHHHHHCEEE	51.13	26051181
404	Succinylation	ISALEEAKKGLAAIK HHHHHHHHHHHCEEE	51.13	23954790
404	Ubiquitination	ISALEEAKKGLAAIK HHHHHHHHHHHCEEE	51.13	-
404 (in isoform 1)	Ubiquitination	-	51.13	21890473
404 (in isoform 2)	Ubiquitination	-	51.13	21906983
405	Ubiquitination	SALEEAKKGLAAIKF HHHHHHHHHHCEEEE	67.23	-
411	Ubiquitination	KKGLAAIKFEGAIYR HHHHCEEEECCCEEE	32.41	21906983
411 (in isoform 1)	Ubiquitination	-	32.41	21890473
411 (in isoform 2)	Ubiquitination	-	32.41	21906983
417	Nitration	IKFEGAIYRKDVGFR EEECCCEEECCCCCH	15.86	-
417	Phosphorylation	IKFEGAIYRKDVGFR EEECCCEEECCCCCH	15.86	25159151
419	Ubiquitination	FEGAIYRKDVGFRAI ECCCEEECCCCCHHE	39.53	-
433	Methylation	IAFLQQPRSLTYKES EEECCCCCCCCCCCC	39.70	-
434	Phosphorylation	AFLQQPRSLTYKESG EECCCCCCCCCCCCC	31.57	23312004
436	Phosphorylation	LQQPRSLTYKESGVD CCCCCCCCCCCCCCE	33.52	23312004
437	Phosphorylation	QQPRSLTYKESGVDI CCCCCCCCCCCCCEE	20.32	23186163
438	Ubiquitination	QPRSLTYKESGVDIA CCCCCCCCCCCCEEC	39.92	21906983
438 (in isoform 1)	Ubiquitination	-	39.92	21890473
440	Phosphorylation	RSLTYKESGVDIAAG CCCCCCCCCCEECCC	39.71	23917254
449	Sulfoxidation	VDIAAGNMLVKKIQP CEECCCCHHHHHHHH	4.44	21406390
452	Acetylation	AAGNMLVKKIQPLAK CCCCHHHHHHHHHHH	39.95	25953088
452	Ubiquitination	AAGNMLVKKIQPLAK CCCCHHHHHHHHHHH	39.95	21890473
452 (in isoform 1)	Ubiquitination	-	39.95	21890473
453	Ubiquitination	AGNMLVKKIQPLAKA CCCHHHHHHHHHHHH	38.81	-
459	2-Hydroxyisobutyrylation	KKIQPLAKATSRSGC HHHHHHHHHHCCCCC	60.94	-
459	Acetylation	KKIQPLAKATSRSGC HHHHHHHHHHCCCCC	60.94	25953088
459	Ubiquitination	KKIQPLAKATSRSGC HHHHHHHHHHCCCCC	60.94	21890473
459 (in isoform 1)	Ubiquitination	-	60.94	21890473
464	Phosphorylation	LAKATSRSGCKVDLG HHHHHCCCCCEEECC	48.59	24719451
466	Glutathionylation	KATSRSGCKVDLGGF HHHCCCCCEEECCCC	4.02	22555962
467	Ubiquitination	ATSRSGCKVDLGGFA HHCCCCCEEECCCCC	42.16	-
480	Methylation	FAGLFDLKAAGFKDP CCCCCCHHHCCCCCC	37.73	-
480	Ubiquitination	FAGLFDLKAAGFKDP CCCCCCHHHCCCCCC	37.73	21890473
480 (in isoform 1)	Ubiquitination	-	37.73	21890473
485	Acetylation	DLKAAGFKDPLLASG CHHHCCCCCCCCCCC	58.48	25953088
485	Ubiquitination	DLKAAGFKDPLLASG CHHHCCCCCCCCCCC	58.48	21890473
485 (in isoform 1)	Ubiquitination	-	58.48	21890473
498	Phosphorylation	SGTDGVGTKLKIAQL CCCCCCCHHHHHHHH	30.69	21815630
499	Ubiquitination	GTDGVGTKLKIAQLC CCCCCCHHHHHHHHC	41.68	-
501	2-Hydroxyisobutyrylation	DGVGTKLKIAQLCNK CCCCHHHHHHHHCCC	37.24	-
501	Ubiquitination	DGVGTKLKIAQLCNK CCCCHHHHHHHHCCC	37.24	-
511	Phosphorylation	QLCNKHDTIGQDLVA HHCCCCCCCCHHHHH	27.08	26074081
546	Phosphorylation	SCGKLDLSVTEAVVA ECCCCCCHHHHHHHH	27.02	28348404
548	Phosphorylation	GKLDLSVTEAVVAGI CCCCCHHHHHHHHHH	18.17	28348404
557	Ubiquitination	AVVAGIAKACGKAGC HHHHHHHHHHCCCCC	42.14	-
561	Ubiquitination	GIAKACGKAGCALLG HHHHHHCCCCCHHCC	41.30	-
598	Acetylation	GAMERDQKLPHLERI HHHHCCCCCCCHHHC	69.17	25953088
598	Ubiquitination	GAMERDQKLPHLERI HHHHCCCCCCCHHHC	69.17	-
616	Phosphorylation	DVVVGIASSGLHSNG CEEEEEECCCCCCCC	24.02	25850435
617	Phosphorylation	VVVGIASSGLHSNGF EEEEEECCCCCCCCH	36.03	24719451
621	Phosphorylation	IASSGLHSNGFSLVR EECCCCCCCCHHHHH	43.63	25850435
625	Phosphorylation	GLHSNGFSLVRKIVA CCCCCCHHHHHHHHH	27.61	25850435
633	Ubiquitination	LVRKIVAKSSLQYSS HHHHHHHHCCCCCCC	29.68	-
646	Glutathionylation	SSPAPDGCGDQTLGD CCCCCCCCCCCCHHH	7.67	22555962
657	Phosphorylation	TLGDLLLTPTRIYSH CHHHHHCCCCEEECC	23.68	24719451
662	Phosphorylation	LLTPTRIYSHSLLPV HCCCCEEECCCHHHH	9.31	28152594
663	Phosphorylation	LTPTRIYSHSLLPVL CCCCEEECCCHHHHH	12.29	28152594
665	Phosphorylation	PTRIYSHSLLPVLRS CCEEECCCHHHHHHC	26.17	28152594
672	Phosphorylation	SLLPVLRSGHVKAFA CHHHHHHCCCCEEEE	29.14	-
676	Ubiquitination	VLRSGHVKAFAHITG HHHCCCCEEEEEECC	31.92	-
682	Phosphorylation	VKAFAHITGGGLLEN CEEEEEECCCHHHHC	21.65	28450419
697	Ubiquitination	IPRVLPEKLGVDLDA CCCCCHHHHCCCCCC	48.91	21890473
697 (in isoform 1)	Ubiquitination	-	48.91	21890473
714	Phosphorylation	WRIPRVFSWLQQEGH CCHHHHHHHHHHCCC	24.82	-
723	Phosphorylation	LQQEGHLSEEEMART HHHCCCCCHHHHHHH	36.97	-
730	Phosphorylation	SEEEMARTFNCGVGA CHHHHHHHCCCCCCE	15.06	20068231
733	Glutathionylation	EMARTFNCGVGAVLV HHHHHCCCCCCEEEE	4.00	22555962
743	Ubiquitination	GAVLVVSKEQTEQIL CEEEEECHHHHHHHH	42.08	-
757	2-Hydroxyisobutyrylation	LRDIQQHKEEAWVIG HHHHHHHHHHHEEEH	53.57	-
757	Acetylation	LRDIQQHKEEAWVIG HHHHHHHHHHHEEEH	53.57	25953088
757	Ubiquitination	LRDIQQHKEEAWVIG HHHHHHHHHHHEEEH	53.57	-
773	Phosphorylation	VVARAEGSPRVKVKN HHHHCCCCCCEEEHH	10.88	23403867
779	Ubiquitination	GSPRVKVKNLIESMQ CCCCEEEHHHHHHHE	40.08	21890473
779 (in isoform 1)	Ubiquitination	-	40.08	21890473
784	Phosphorylation	KVKNLIESMQINGSV EEHHHHHHHEECCEE	14.70	23186163
790	Phosphorylation	ESMQINGSVLKNGSL HHHEECCEEECCCCC	21.56	28555341
796	Phosphorylation	GSVLKNGSLTNHFSF CEEECCCCCCCCCCC	41.22	23401153
798	Phosphorylation	VLKNGSLTNHFSFEK EECCCCCCCCCCCCC	28.48	23927012
802	Phosphorylation	GSLTNHFSFEKKKAR CCCCCCCCCCCCCCE	25.58	23401153
805	Ubiquitination	TNHFSFEKKKARVAV CCCCCCCCCCCEEEE	58.52	-
806	Ubiquitination	NHFSFEKKKARVAVL CCCCCCCCCCEEEEE	44.46	-
815	Phosphorylation	ARVAVLISGTGSNLQ CEEEEEEECCCHHHH	26.58	27080861
817	Phosphorylation	VAVLISGTGSNLQAL EEEEEECCCHHHHHH	30.55	20068231
819	Phosphorylation	VLISGTGSNLQALID EEEECCCHHHHHHHH	33.92	20068231
827	Phosphorylation	NLQALIDSTREPNSS HHHHHHHCCCCCCCC	23.52	20068231
828	Phosphorylation	LQALIDSTREPNSSA HHHHHHCCCCCCCCC	34.99	27080861
844	Acetylation	IDIVISNKAAVAGLD EEEEECCHHHHCCCC	30.82	19811569
852	2-Hydroxyisobutyrylation	AAVAGLDKAERAGIP HHHCCCCHHHHCCCC	58.13	-
852	Acetylation	AAVAGLDKAERAGIP HHHCCCCHHHHCCCC	58.13	23749302
852	Malonylation	AAVAGLDKAERAGIP HHHCCCCHHHHCCCC	58.13	26320211
852	Ubiquitination	AAVAGLDKAERAGIP HHHCCCCHHHHCCCC	58.13	-
855	Methylation	AGLDKAERAGIPTRV CCCCHHHHCCCCHHH	42.87	-
860	Phosphorylation	AERAGIPTRVINHKL HHHCCCCHHHCCCHH	35.33	-
866	Acetylation	PTRVINHKLYKNRVE CHHHCCCHHHCCCCC	49.36	25953088
866	Ubiquitination	PTRVINHKLYKNRVE CHHHCCCHHHCCCCC	49.36	-
900	Phosphorylation	AGFMRILSGPFVQKW HHHHHHHCCCHHHCC	41.89	20068231
906	Ubiquitination	LSGPFVQKWNGKMLN HCCCHHHCCCCEECC	37.01	-
910	Ubiquitination	FVQKWNGKMLNIHPS HHHCCCCEECCCCHH	36.68	21890473
910 (in isoform 1)	Ubiquitination	-	36.68	21890473
921	Phosphorylation	IHPSLLPSFKGSNAH CCHHHCCCCCCCCHH	39.29	24719451
977	Ubiquitination	ATLSERVKLAEHKIF EEHHHHHHHHHCCHH	48.47	-
982	Acetylation	RVKLAEHKIFPAALQ HHHHHHCCHHHHHHH	37.23	156527
1008	Ubiquitination	NGKICWVKEE----- CCCEEEEECC-----	31.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUR2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR6_HUMAN	PAICS	physical	22939629
SPS1_HUMAN	SEPHS1	physical	22939629
SYWC_HUMAN	WARS	physical	22939629
PAXI_HUMAN	PXN	physical	21988832
IMA1_HUMAN	KPNA2	physical	21988832
SYCC_HUMAN	CARS	physical	22863883
HIRP3_HUMAN	HIRIP3	physical	22863883
HSP74_HUMAN	HSPA4	physical	22863883
RANB3_HUMAN	RANBP3	physical	22863883
RL24_HUMAN	RPL24	physical	22863883
SET_HUMAN	SET	physical	22863883
SF01_HUMAN	SF1	physical	22863883
SPT5H_HUMAN	SUPT5H	physical	22863883
SWP70_HUMAN	SWAP70	physical	22863883
RO60_HUMAN	TROVE2	physical	22863883
XPO7_HUMAN	XPO7	physical	22863883
ZYX_HUMAN	ZYX	physical	22863883
PUR8_HUMAN	ADSL	physical	26344197
AK1C2_HUMAN	AKR1C2	physical	26344197
ARFP1_HUMAN	ARFIP1	physical	26344197
IF4H_HUMAN	EIF4H	physical	26344197
HIP1R_HUMAN	HIP1R	physical	26344197
ROA1_HUMAN	HNRNPA1	physical	26344197
PUR4_HUMAN	PFAS	physical	26344197
DHPR_HUMAN	QDPR	physical	26344197
RAVR1_HUMAN	RAVER1	physical	26344197
SPS1_HUMAN	SEPHS1	physical	26344197
STAT6_HUMAN	STAT6	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00642	Pemetrexed

Regulatory Network of PUR2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-350, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-348, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-348, AND MASSSPECTROMETRY.	15592455 [Abstract]