RA1L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RA1L2_HUMAN
• UniProt AC: Q32P51
• Protein Name: Heterogeneous nuclear ribonucleoprotein A1-like 2
• Gene Name: HNRNPA1L2
• Organism: Homo sapiens (Human).
• Sequence Length: 320
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection..
• Protein Sequence: MSKSASPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNTTPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVKGHNCEVRKALPKQEMASASSSQRGRRGSGNFGGGRGDGFGGNDNFGRGGNFSGRGGFGGSCGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPQNQGGYGVSSSSSSYGSGRRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKSASPKE ------CCCCCCCCC	35.00	26074081
4	Phosphorylation	----MSKSASPKEPE ----CCCCCCCCCHH	27.03	29632367
6	Phosphorylation	--MSKSASPKEPEQL --CCCCCCCCCHHHH	43.53	29632367
14	Methylation	PKEPEQLRKLFIGGL CCCHHHHHHHHHCCC	33.07	30759987
15	Sumoylation	KEPEQLRKLFIGGLS CCHHHHHHHHHCCCC	57.23	-
15	Ubiquitination	KEPEQLRKLFIGGLS CCHHHHHHHHHCCCC	57.23	21890473
15	Acetylation	KEPEQLRKLFIGGLS CCHHHHHHHHHCCCC	57.23	24677463
15	Sumoylation	KEPEQLRKLFIGGLS CCHHHHHHHHHCCCC	57.23	-
22	Phosphorylation	KLFIGGLSFETTDES HHHHCCCCCCCCCHH	25.06	30266825
25	Phosphorylation	IGGLSFETTDESLRS HCCCCCCCCCHHHHH	37.22	30266825
26	Phosphorylation	GGLSFETTDESLRSH CCCCCCCCCHHHHHH	30.48	30266825
29	Phosphorylation	SFETTDESLRSHFEQ CCCCCCHHHHHHHHH	31.71	30266825
31	Methylation	ETTDESLRSHFEQWG CCCCHHHHHHHHHHC	37.05	24390981
39	Phosphorylation	SHFEQWGTLTDCVVM HHHHHHCCEEEEEEE	24.43	28857561
41	Phosphorylation	FEQWGTLTDCVVMRD HHHHCCEEEEEEEEC	27.47	20068231
52	Acetylation	VMRDPNTKRSRGFGF EEECCCCCCCCCCEE	55.82	12429977
52	Ubiquitination	VMRDPNTKRSRGFGF EEECCCCCCCCCCEE	55.82	21890473
61	Phosphorylation	SRGFGFVTYATVEEV CCCCEEEEEEEHHHH	12.74	-
62	Phosphorylation	RGFGFVTYATVEEVD CCCEEEEEEEHHHHH	8.58	-
74	Phosphorylation	EVDAAMNTTPHKVDG HHHHHHCCCCCEECC	28.72	21082442
74	O-linked_Glycosylation	EVDAAMNTTPHKVDG HHHHHHCCCCCEECC	28.72	23301498
75	O-linked_Glycosylation	VDAAMNTTPHKVDGR HHHHHCCCCCEECCE	20.56	23301498
87	Ubiquitination	DGRVVEPKRAVSRED CCEEECCCCCCCCCC	39.21	-
87	Sumoylation	DGRVVEPKRAVSRED CCEEECCCCCCCCCC	39.21	-
87	Acetylation	DGRVVEPKRAVSRED CCEEECCCCCCCCCC	39.21	30585957
91	Phosphorylation	VEPKRAVSREDSQRP ECCCCCCCCCCCCCC	29.03	25159151
95	Phosphorylation	RAVSREDSQRPGAHL CCCCCCCCCCCCCEE	24.28	25159151
103	Phosphorylation	QRPGAHLTVKKIFVG CCCCCEEEEEEEEEC	22.03	25159151
105	Sumoylation	PGAHLTVKKIFVGGI CCCEEEEEEEEECCC	34.61	-
105	Acetylation	PGAHLTVKKIFVGGI CCCEEEEEEEEECCC	34.61	21671647
105	Ubiquitination	PGAHLTVKKIFVGGI CCCEEEEEEEEECCC	34.61	-
106	Ubiquitination	GAHLTVKKIFVGGIK CCEEEEEEEEECCCC	36.72	-
106	Methylation	GAHLTVKKIFVGGIK CCEEEEEEEEECCCC	36.72	24633831
113	Acetylation	KIFVGGIKEDTEEHH EEEECCCCCCCCHHH	53.46	22631313
113	Sumoylation	KIFVGGIKEDTEEHH EEEECCCCCCCCHHH	53.46	-
113	Ubiquitination	KIFVGGIKEDTEEHH EEEECCCCCCCCHHH	53.46	-
116	Phosphorylation	VGGIKEDTEEHHLRD ECCCCCCCCHHHHHH	44.35	20873877
122	Methylation	DTEEHHLRDYFEQYG CCCHHHHHHHHHHHC	32.02	-
124	Phosphorylation	EEHHLRDYFEQYGKI CHHHHHHHHHHHCCE	11.55	28152594
128	Phosphorylation	LRDYFEQYGKIEVIE HHHHHHHHCCEEEEE	17.12	28152594
138	Phosphorylation	IEVIEIMTDRGSGKK EEEEEEEEECCCCCC	28.36	21712546
140	Methylation	VIEIMTDRGSGKKRG EEEEEEECCCCCCCE	31.82	30759987
142	Phosphorylation	EIMTDRGSGKKRGFA EEEEECCCCCCCEEE	48.62	25159151
144	Ubiquitination	MTDRGSGKKRGFAFV EEECCCCCCCEEEEE	40.78	-
144	Sumoylation	MTDRGSGKKRGFAFV EEECCCCCCCEEEEE	40.78	-
144	Acetylation	MTDRGSGKKRGFAFV EEECCCCCCCEEEEE	40.78	12422165
145	Acetylation	TDRGSGKKRGFAFVT EECCCCCCCEEEEEE	62.37	12422173
146	Methylation	DRGSGKKRGFAFVTF ECCCCCCCEEEEEEC	49.28	-
152	Phosphorylation	KRGFAFVTFDDHDSV CCEEEEEECCCCCCC	18.20	28857561
158	Phosphorylation	VTFDDHDSVDKIVIQ EECCCCCCCCEEEEE	28.88	20873877
161	Methylation	DDHDSVDKIVIQKYH CCCCCCCEEEEEEEC	36.40	-
161	Ubiquitination	DDHDSVDKIVIQKYH CCCCCCCEEEEEEEC	36.40	-
166	Ubiquitination	VDKIVIQKYHTVKGH CCEEEEEEECCCCCC	28.07	-
169	Phosphorylation	IVIQKYHTVKGHNCE EEEEEECCCCCCCCC	22.33	-
171	Ubiquitination	IQKYHTVKGHNCEVR EEEECCCCCCCCCHH	56.46	-
188	Phosphorylation	LPKQEMASASSSQRG CCHHHHHCCCCCCCC	27.63	20860994
190	Phosphorylation	KQEMASASSSQRGRR HHHHHCCCCCCCCCC	28.20	20860994
191	Phosphorylation	QEMASASSSQRGRRG HHHHCCCCCCCCCCC	30.15	23401153
192	Phosphorylation	EMASASSSQRGRRGS HHHCCCCCCCCCCCC	22.77	20860994
194	Asymmetric dimethylarginine	ASASSSQRGRRGSGN HCCCCCCCCCCCCCC	42.40	-
194	Methylation	ASASSSQRGRRGSGN HCCCCCCCCCCCCCC	42.40	18601085
196	Dimethylation	ASSSQRGRRGSGNFG CCCCCCCCCCCCCCC	41.81	-
196	Methylation	ASSSQRGRRGSGNFG CCCCCCCCCCCCCCC	41.81	30759991
197	Methylation	SSSQRGRRGSGNFGG CCCCCCCCCCCCCCC	46.59	115479459
206	Methylation	SGNFGGGRGDGFGGN CCCCCCCCCCCCCCC	43.22	-
206	Asymmetric dimethylarginine	SGNFGGGRGDGFGGN CCCCCCCCCCCCCCC	43.22	-
218	Methylation	GGNDNFGRGGNFSGR CCCCCCCCCCCCCCC	45.79	58855637
218	Asymmetric dimethylarginine	GGNDNFGRGGNFSGR CCCCCCCCCCCCCCC	45.79	-
225	Methylation	RGGNFSGRGGFGGSC CCCCCCCCCCCCCCC	40.64	30759983
225	Asymmetric dimethylarginine	RGGNFSGRGGFGGSC CCCCCCCCCCCCCCC	40.64	-
244	Phosphorylation	YGGSGDGYNGFGNDG CCCCCCCCCCCCCCC	19.49	28985074
260	Phosphorylation	NFGGGGSYNDFGNYN CCCCCCCCCCCCCCC	23.25	-
266	Phosphorylation	SYNDFGNYNNQSSNF CCCCCCCCCCCCCCC	18.83	-
284	Methylation	KGGNFGGRSSGPYGG CCCCCCCCCCCCCCC	28.20	18600471
285	Phosphorylation	GGNFGGRSSGPYGGG CCCCCCCCCCCCCCC	42.81	23401153
286	Phosphorylation	GNFGGRSSGPYGGGG CCCCCCCCCCCCCCC	42.29	22167270
289	Phosphorylation	GGRSSGPYGGGGQYF CCCCCCCCCCCCCCE	31.74	22167270
295	Phosphorylation	PYGGGGQYFAKPQNQ CCCCCCCCEECCCCC	14.58	20090780
298	Methylation	GGGQYFAKPQNQGGY CCCCCEECCCCCCCC	36.92	-
298	Acetylation	GGGQYFAKPQNQGGY CCCCCEECCCCCCCC	36.92	26051181
298	Ubiquitination	GGGQYFAKPQNQGGY CCCCCEECCCCCCCC	36.92	-
316	Phosphorylation	SSSSSYGSGRRF--- CCCCCCCCCCCC---	22.39	19664995

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RA1L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RA1L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RA1L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROA3_HUMAN	HNRNPA3	physical	22939629
RAB1A_HUMAN	RAB1A	physical	22939629
SERPH_HUMAN	SERPINH1	physical	22939629
FPPS_HUMAN	FDPS	physical	26344197
HNRPF_HUMAN	HNRNPF	physical	26344197
HNRH1_HUMAN	HNRNPH1	physical	26344197
HNRH2_HUMAN	HNRNPH2	physical	26344197
HNRH3_HUMAN	HNRNPH3	physical	26344197
TOX4_HUMAN	TOX4	physical	26496610
KIF14_HUMAN	KIF14	physical	26496610
TRIB1_HUMAN	TRIB1	physical	26496610
PUR6_HUMAN	PAICS	physical	26496610
SIR1_HUMAN	SIRT1	physical	26496610
QCR8_HUMAN	UQCRQ	physical	26496610
STX18_HUMAN	STX18	physical	26496610
TGO1_HUMAN	MIA3	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.