ARM10_HUMAN - dbPTM
ARM10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARM10_HUMAN
UniProt AC Q8N2F6
Protein Name Armadillo repeat-containing protein 10
Gene Name ARMC10
Organism Homo sapiens (Human).
Sequence Length 343
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein .
Protein Description May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53..
Protein Sequence MGGPRGAGWVAAGLLLGAGACYCIYRLTRGRRRGDRELGIRSSKSAGALEEGTSEGQLCGRSARPQTGGTWESQWSKTSQPEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDHQHMLHSYITDLFQVLLTGNGNTKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHVAKEILLRVLTLFQNIKNCLKIEGHLAVQPTFTEGSLFFLLHGEECAQKIRALVDHHDAEVKEKVVTIIPKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationAGACYCIYRLTRGRR
CHHHHHHHHHHCCCC		8.94-
28PhosphorylationCYCIYRLTRGRRRGD
HHHHHHHHCCCCCCC		23.29-
42PhosphorylationDRELGIRSSKSAGAL
CCCCCCCCCCCCCCC		39.9523401153
42 (in isoform 6)Phosphorylation-39.9523927012
42 (in isoform 5)Phosphorylation-39.9523927012
42 (in isoform 4)Phosphorylation-39.9523927012
42 (in isoform 2)Phosphorylation-39.9523927012
43PhosphorylationRELGIRSSKSAGALE
CCCCCCCCCCCCCCC		22.3023911959
43 (in isoform 6)Phosphorylation-22.3023927012
43 (in isoform 5)Phosphorylation-22.3023927012
43 (in isoform 4)Phosphorylation-22.3023927012
43 (in isoform 2)Phosphorylation-22.3023927012
44 (in isoform 2)Ubiquitination-45.6421906983
44 (in isoform 4)Ubiquitination-45.6421906983
44UbiquitinationELGIRSSKSAGALEE
CCCCCCCCCCCCCCC		45.64-
45 (in isoform 4)Phosphorylation-33.6022167270
45 (in isoform 6)Phosphorylation-33.6022167270
45PhosphorylationLGIRSSKSAGALEEG
CCCCCCCCCCCCCCC		33.6025159151
45 (in isoform 2)Phosphorylation-33.6022167270
45 (in isoform 5)Phosphorylation-33.6022167270
50 (in isoform 4)Phosphorylation-54.5730266825
50 (in isoform 6)Phosphorylation-54.5730266825
50 (in isoform 2)Phosphorylation-54.5730266825
50 (in isoform 5)Phosphorylation-54.5730266825
53 (in isoform 5)Phosphorylation-27.2130266825
53 (in isoform 4)Phosphorylation-27.2130266825
53 (in isoform 2)Phosphorylation-27.2130266825
53 (in isoform 6)Phosphorylation-27.2130266825
53PhosphorylationAGALEEGTSEGQLCG
CCCCCCCCCCCCCCC		27.2123927012
54 (in isoform 5)Phosphorylation-51.0619690332
54PhosphorylationGALEEGTSEGQLCGR
CCCCCCCCCCCCCCC		51.0623927012
54 (in isoform 2)Phosphorylation-51.0619690332
54 (in isoform 4)Phosphorylation-51.0619690332
54 (in isoform 6)Phosphorylation-51.0619690332
62PhosphorylationEGQLCGRSARPQTGG
CCCCCCCCCCCCCCC		17.57-
77UbiquitinationTWESQWSKTSQPEDL
CCHHCCCCCCCCCCC		49.60-
78PhosphorylationWESQWSKTSQPEDLT
CHHCCCCCCCCCCCC		27.3826471730
79PhosphorylationESQWSKTSQPEDLTD
HHCCCCCCCCCCCCC		47.6926471730
85PhosphorylationTSQPEDLTDGSYDDV
CCCCCCCCCCCHHHC		51.1126471730
88PhosphorylationPEDLTDGSYDDVLNA
CCCCCCCCHHHCCCH		28.3528796482
89PhosphorylationEDLTDGSYDDVLNAE
CCCCCCCHHHCCCHH		22.9928796482
120 (in isoform 2)Ubiquitination-29.4821906983
120 (in isoform 4)Ubiquitination-29.4821906983
146UbiquitinationGIPIVANKINHSNQS
CCCEEEECCCCCCHH		34.84-
155 (in isoform 3)Ubiquitination-59.4121906983
155UbiquitinationNHSNQSIKEKALNAL
CCCCHHHHHHHHHHH		59.412190698
155 (in isoform 1)Ubiquitination-59.4121906983
157UbiquitinationSNQSIKEKALNALNN
CCHHHHHHHHHHHHC		53.85-
239 (in isoform 2)Ubiquitination-1.48-
262PhosphorylationLLRAQVDSSFLSLYD
HHHHHCCHHHHHHHC		24.9221406692
263PhosphorylationLRAQVDSSFLSLYDS
HHHHCCHHHHHHHCH		26.2421406692
266PhosphorylationQVDSSFLSLYDSHVA
HCCHHHHHHHCHHHH		23.9121406692
268PhosphorylationDSSFLSLYDSHVAKE
CHHHHHHHCHHHHHH		16.4221406692
270PhosphorylationSFLSLYDSHVAKEIL
HHHHHHCHHHHHHHH		13.3021406692
300 (in isoform 2)Ubiquitination-26.21-
333UbiquitinationDHHDAEVKEKVVTII
HCCCHHHHHHEEEEE		43.24-
335UbiquitinationHDAEVKEKVVTIIPK
CCHHHHHHEEEEEEC		35.97-
338PhosphorylationEVKEKVVTIIPKI--
HHHHHEEEEEECC--		19.0428857561
342UbiquitinationKVVTIIPKI------
HEEEEEECC------		51.11-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
45SPhosphorylationKinaseAMPKA2P54646
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARM10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARM10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ARM10_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARM10_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.

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