MTX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTX1_HUMAN
• UniProt AC: Q13505
• Protein Name: Metaxin-1
• Gene Name: MTX1
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Mitochondrion outer membrane.
• Protein Description: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity)..
• Protein Sequence: MLLGGPPRSPRSGTSPKGPWSSTGHVQFGKSPQTWPRRTRPRSPEPAAPSGVRGSTWTRRRDSPRRAGPTALSRYVGHLWMGRRPPSPEARGPVPRSSAASRARRSLASPGISPGPLTATIGGAVAGGGPRQGRAEAHKEVFPGQRVGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKISNPWQSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYFPWDGAEVPPQRQTPAGPETEEEPYRRRNQILSVLAGLAAMVGYALLSGIVSIQRATPARAPGTRTLGMAEEDEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	LLGGPPRSPRSGTSP CCCCCCCCCCCCCCC	30.36	25106551
12	Phosphorylation	GPPRSPRSGTSPKGP CCCCCCCCCCCCCCC	50.21	28509920
14	Phosphorylation	PRSPRSGTSPKGPWS CCCCCCCCCCCCCCC	43.00	28509920
15	Phosphorylation	RSPRSGTSPKGPWSS CCCCCCCCCCCCCCC	28.30	-
39	Phosphorylation	PQTWPRRTRPRSPEP CCCCCCCCCCCCCCC	46.43	28985074
41 (in isoform 3)	Ubiquitination	-	40.25	21890473
43	Phosphorylation	PRRTRPRSPEPAAPS CCCCCCCCCCCCCCC	35.98	30266825
50	Phosphorylation	SPEPAAPSGVRGSTW CCCCCCCCCCCCCCC	45.23	23312004
69 (in isoform 3)	Ubiquitination	-	17.32	21890473
70	Phosphorylation	SPRRAGPTALSRYVG CCCCCCHHHHHHHCH	39.03	21955146
73	Phosphorylation	RAGPTALSRYVGHLW CCCHHHHHHHCHHHH	21.07	21955146
78 (in isoform 3)	Ubiquitination	-	13.28	21890473
87	Phosphorylation	WMGRRPPSPEARGPV HCCCCCCCHHHCCCC	37.75	22985185
101	Phosphorylation	VPRSSAASRARRSLA CCCHHHHHHHHHHHC	26.62	-
106	Phosphorylation	AASRARRSLASPGIS HHHHHHHHHCCCCCC	23.80	21712546
109	Phosphorylation	RARRSLASPGISPGP HHHHHHCCCCCCCCC	29.02	21712546
113	Phosphorylation	SLASPGISPGPLTAT HHCCCCCCCCCCEEE	29.71	21712546
118	Phosphorylation	GISPGPLTATIGGAV CCCCCCCEEEECCHH	25.53	21712546
125 (in isoform 3)	Ubiquitination	-	6.02	21890473
168 (in isoform 3)	Ubiquitination	-	8.82	21890473
187	Ubiquitination	RFTGAPLKVHKISNP HHHCCCEEEEECCCC	41.03	23000965
190 (in isoform 2)	Ubiquitination	-	51.31	21890473
190	Ubiquitination	GAPLKVHKISNPWQS CCCEEEEECCCCCCC	51.31	23000965
190 (in isoform 1)	Ubiquitination	-	51.31	21890473
192	Phosphorylation	PLKVHKISNPWQSPS CEEEEECCCCCCCCC	41.46	28176443
197	Phosphorylation	KISNPWQSPSGTLPA ECCCCCCCCCCCCCC	19.71	25159151
199	Phosphorylation	SNPWQSPSGTLPALR CCCCCCCCCCCCCCC	50.05	28176443
201	Phosphorylation	PWQSPSGTLPALRTS CCCCCCCCCCCCCCC	33.63	28176443
207	Phosphorylation	GTLPALRTSHGEVIS CCCCCCCCCCCEEEE	26.40	28176443
208	Phosphorylation	TLPALRTSHGEVISV CCCCCCCCCCEEEEC	24.06	28176443
214	Phosphorylation	TSHGEVISVPHKIIT CCCCEEEECCHHHHH	34.47	28176443
218 (in isoform 1)	Ubiquitination	-	29.72	21890473
218	Ubiquitination	EVISVPHKIITHLRK EEEECCHHHHHHHHH	29.72	21963094
218 (in isoform 2)	Ubiquitination	-	29.72	21890473
225	Ubiquitination	KIITHLRKEKYNADY HHHHHHHHHHHCCCC	65.99	22817900
227 (in isoform 1)	Ubiquitination	-	47.00	21890473
227	Acetylation	ITHLRKEKYNADYDL HHHHHHHHHCCCCCH	47.00	27452117
227	Ubiquitination	ITHLRKEKYNADYDL HHHHHHHHHCCCCCH	47.00	27667366
227	2-Hydroxyisobutyrylation	ITHLRKEKYNADYDL HHHHHHHHHCCCCCH	47.00	-
228	Phosphorylation	THLRKEKYNADYDLS HHHHHHHHCCCCCHH	19.37	20860994
232	Phosphorylation	KEKYNADYDLSARQG HHHHCCCCCHHHHCC	19.17	28796482
235	Phosphorylation	YNADYDLSARQGADT HCCCCCHHHHCCHHH	20.64	20860994
243 (in isoform 2)	Ubiquitination	-	3.39	21890473
243	Ubiquitination	ARQGADTLAFMSLLE HHCCHHHHHHHHHHH	3.39	22817900
247	Phosphorylation	ADTLAFMSLLEEKLL HHHHHHHHHHHHHHH	24.29	24719451
274 (in isoform 1)	Ubiquitination	-	34.88	21890473
274	Ubiquitination	NYVEVTRKWYAEAMP CCCHHHHHHHHHHCC	34.88	22817900
286	Ubiquitination	AMPFPLNFFLPGRMQ HCCCCCCCCCCHHHH	9.79	21963094
286 (in isoform 2)	Ubiquitination	-	9.79	21890473
317 (in isoform 1)	Ubiquitination	-	66.69	21890473
317	Ubiquitination	EDEEELEKELYREAR CCHHHHHHHHHHHHH	66.69	21963094
331	Phosphorylation	RECLTLLSQRLGSQK HHHHHHHHHHHCCCC	19.16	24719451
366	Phosphorylation	LLQAKLPSGKLQVHL HHHCCCCCCCEEEEH	60.02	24719451
368	Ubiquitination	QAKLPSGKLQVHLRG HCCCCCCCEEEEHHH	39.83	-
404	Phosphorylation	EVPPQRQTPAGPETE CCCCCCCCCCCCCCC	19.80	21815630
410	Phosphorylation	QTPAGPETEEEPYRR CCCCCCCCCCCHHHH	52.40	-
415	Phosphorylation	PETEEEPYRRRNQIL CCCCCCHHHHHHHHH	21.74	-
434	Phosphorylation	GLAAMVGYALLSGIV HHHHHHHHHHHHCHH	5.22	24532841
438	Phosphorylation	MVGYALLSGIVSIQR HHHHHHHHCHHHHHC	27.59	24532841
442	Phosphorylation	ALLSGIVSIQRATPA HHHHCHHHHHCCCCC	15.87	24532841
447	Phosphorylation	IVSIQRATPARAPGT HHHHHCCCCCCCCCC	21.48	24532841
454	Phosphorylation	TPARAPGTRTLGMAE CCCCCCCCCCCCCCC	21.30	24532841

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GHITM_HUMAN	GHITM	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.