FUND2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUND2_HUMAN
• UniProt AC: Q9BWH2
• Protein Name: FUN14 domain-containing protein 2
• Gene Name: FUNDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Protein Sequence: METSAPRAGSQVVATTARHSAAYRADPLRVSSRDKLTEMAASSQGNFEGNFESLDLAEFAKKQPWWRKLFGQESGPSAEKYSVATQLFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVRSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	TSAPRAGSQVVATTA CCCCCCCCCEEEEEC	20.86	25159151
15	Phosphorylation	AGSQVVATTARHSAA CCCCEEEEECCCCHH	14.91	23312004
16	Phosphorylation	GSQVVATTARHSAAY CCCEEEEECCCCHHH	16.38	29214152
20	Phosphorylation	VATTARHSAAYRADP EEEECCCCHHHHCCC	14.72	29214152
23	Phosphorylation	TARHSAAYRADPLRV ECCCCHHHHCCCCCC	13.17	30177828
31	Phosphorylation	RADPLRVSSRDKLTE HCCCCCCCCHHHHHH	17.14	30266825
32	Phosphorylation	ADPLRVSSRDKLTEM CCCCCCCCHHHHHHH	41.46	30266825
37	Phosphorylation	VSSRDKLTEMAASSQ CCCHHHHHHHHHHCC	29.47	28857561
42	Phosphorylation	KLTEMAASSQGNFEG HHHHHHHHCCCCCCC	17.41	28857561
43	Phosphorylation	LTEMAASSQGNFEGN HHHHHHHCCCCCCCC	37.06	28857561
53	Phosphorylation	NFEGNFESLDLAEFA CCCCCCCCCCHHHHH	24.05	25693802
61	Ubiquitination	LDLAEFAKKQPWWRK CCHHHHHHHCHHHHH	58.21	21963094
62	Ubiquitination	DLAEFAKKQPWWRKL CHHHHHHHCHHHHHH	59.15	-
68	Ubiquitination	KKQPWWRKLFGQESG HHCHHHHHHHCCCCC	34.15	21906983
147	Ubiquitination	KKAKEQLKIRKSNQI HHHHHHHHHHHHCCC	39.91	23000965
150	Ubiquitination	KEQLKIRKSNQIPTE HHHHHHHHHCCCCHH	58.18	23000965
151	Phosphorylation	EQLKIRKSNQIPTEV HHHHHHHHCCCCHHH	24.90	29255136
156	Phosphorylation	RKSNQIPTEVRSKAE HHHCCCCHHHHHHHH	49.06	24702127
161	Ubiquitination	IPTEVRSKAEEVVSF CCHHHHHHHHHHHHH	49.61	21906983
167	Phosphorylation	SKAEEVVSFVKKNVL HHHHHHHHHHHCCEE	29.51	20833797
170	Ubiquitination	EEVVSFVKKNVLVTG HHHHHHHHCCEEEEC	36.30	33845483
176	Phosphorylation	VKKNVLVTGGFFGGF HHCCEEEECCCCHHH	27.68	-
189	Phosphorylation	GFLLGMAS------- HHHHCCCC-------	31.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUND2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUND2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUND2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FUND2_HUMAN	FUNDC2	physical	25416956
SEC62_HUMAN	SEC62	physical	26186194
FAF2_HUMAN	FAF2	physical	26186194
FUND1_HUMAN	FUNDC1	physical	26186194
FAF2_HUMAN	FAF2	physical	28514442
FUND1_HUMAN	FUNDC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASSSPECTROMETRY.
PubMed: 19690332

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASSSPECTROMETRY.
PubMed: 18691976

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASSSPECTROMETRY.
PubMed: 17081983