CMTD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CMTD1_HUMAN
• UniProt AC: Q86VU5
• Protein Name: Catechol O-methyltransferase domain-containing protein 1
• Gene Name: COMTD1
• Organism: Homo sapiens (Human).
• Sequence Length: 262
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Putative O-methyltransferase..
• Protein Sequence: MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	PAALALGSAALGAAF HHHHHHHHHHHHHHH	15.95	24719451
27	Phosphorylation	ALGAAFATGLFLGRR HHHHHHHHCHHHCCC	28.15	24719451
35	S-palmitoylation	GLFLGRRCPPWRGRR CHHHCCCCCCCCCCC	4.59	29575903
71	Phosphorylation	REHPALRSLRLLTLE HHCHHHHHHEEEEEC	20.77	26670566
161	Ubiquitination	HKIDLRLKPALETLD HHCCCCCHHHHHHHH	23.08	29967540
224	Ubiquitination	GKVLQPPKGDVAAEC CCCCCCCCCCHHHHH	74.54	33845483
246	Phosphorylation	IRRDVRVYISLLPLG HHHHHHHEEEEEECC	3.68	29083192
248	Phosphorylation	RDVRVYISLLPLGDG HHHHHEEEEEECCCC	13.23	29083192
257	Phosphorylation	LPLGDGLTLAFKI-- EECCCCEEEEEEC--	22.90	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CMTD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CMTD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CMTD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSTO1_HUMAN	MSTO1	physical	26186194
KPB1_HUMAN	PHKA1	physical	26186194
SYEP_HUMAN	EPRS	physical	26186194
IF4G3_HUMAN	EIF4G3	physical	26186194
DDX20_HUMAN	DDX20	physical	26186194
SYRC_HUMAN	RARS	physical	26186194
SYDC_HUMAN	DARS	physical	26186194
SETX_HUMAN	SETX	physical	26186194
TFP11_HUMAN	TFIP11	physical	26186194
BZW1_HUMAN	BZW1	physical	26186194
IPO7_HUMAN	IPO7	physical	26186194
HEAT3_HUMAN	HEATR3	physical	26186194
TNPO2_HUMAN	TNPO2	physical	26186194
AIMP1_HUMAN	AIMP1	physical	26186194
PEX19_HUMAN	PEX19	physical	26186194
SAAL1_HUMAN	SAAL1	physical	26186194
DIAP3_HUMAN	DIAPH3	physical	26186194
COG2_HUMAN	COG2	physical	26186194
HIP1R_HUMAN	HIP1R	physical	26186194
XPO4_HUMAN	XPO4	physical	26186194
RGPD5_HUMAN	RGPD5	physical	26186194
RBP2_HUMAN	RANBP2	physical	26186194
SYIC_HUMAN	IARS	physical	26186194
SUGP1_HUMAN	SUGP1	physical	26186194
P4R3B_HUMAN	SMEK2	physical	26186194
SOSSC_HUMAN	INIP	physical	26186194
ANM9_HUMAN	PRMT9	physical	26186194
PDCD4_HUMAN	PDCD4	physical	26186194
IPO11_HUMAN	IPO11	physical	26186194
PBIP1_HUMAN	PBXIP1	physical	26186194
WAPL_HUMAN	WAPAL	physical	26186194
NUP98_HUMAN	NUP98	physical	26186194
DAAF5_HUMAN	DNAAF5	physical	26186194
UBP28_HUMAN	USP28	physical	26186194
CIP2A_HUMAN	KIAA1524	physical	26186194
HOOK3_HUMAN	HOOK3	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
IFRD1_HUMAN	IFRD1	physical	26186194
IPO9_HUMAN	IPO9	physical	26186194
INT3_HUMAN	INTS3	physical	26186194
MIGA1_HUMAN	FAM73A	physical	26186194
EI2BE_HUMAN	EIF2B5	physical	26186194
PHKG2_HUMAN	PHKG2	physical	26186194
S39A6_HUMAN	SLC39A6	physical	26186194
GEMI5_HUMAN	GEMIN5	physical	26186194
S11IP_HUMAN	STK11IP	physical	26186194
CCNT1_HUMAN	CCNT1	physical	26186194
PP4R2_HUMAN	PPP4R2	physical	26186194
PUR8_HUMAN	ADSL	physical	26186194
HAUS7_HUMAN	HAUS7	physical	26186194
GEMI2_HUMAN	GEMIN2	physical	26186194
COG5_HUMAN	COG5	physical	26186194
NUP37_HUMAN	NUP37	physical	26186194
STAG2_HUMAN	STAG2	physical	26186194
IFRD1_HUMAN	IFRD1	physical	28514442
UBP28_HUMAN	USP28	physical	28514442
KPB1_HUMAN	PHKA1	physical	28514442
ANM9_HUMAN	PRMT9	physical	28514442
WAPL_HUMAN	WAPAL	physical	28514442
PEX19_HUMAN	PEX19	physical	28514442
MIGA1_HUMAN	FAM73A	physical	28514442
PHKG2_HUMAN	PHKG2	physical	28514442
SUGP1_HUMAN	SUGP1	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
CIP2A_HUMAN	KIAA1524	physical	28514442
HAUS7_HUMAN	HAUS7	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
PDCD4_HUMAN	PDCD4	physical	28514442
INT3_HUMAN	INTS3	physical	28514442
GEMI5_HUMAN	GEMIN5	physical	28514442
MSTO1_HUMAN	MSTO1	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
P4R3B_HUMAN	SMEK2	physical	28514442
STAG2_HUMAN	STAG2	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442
PUR8_HUMAN	ADSL	physical	28514442
GEMI2_HUMAN	GEMIN2	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
SETX_HUMAN	SETX	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
HOOK3_HUMAN	HOOK3	physical	28514442
DIAP3_HUMAN	DIAPH3	physical	28514442
PBIP1_HUMAN	PBXIP1	physical	28514442
CCNT1_HUMAN	CCNT1	physical	28514442
HIP1R_HUMAN	HIP1R	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
S11IP_HUMAN	STK11IP	physical	28514442
IPO11_HUMAN	IPO11	physical	28514442
SYIC_HUMAN	IARS	physical	28514442
SOSSC_HUMAN	INIP	physical	28514442
SYDC_HUMAN	DARS	physical	28514442
IF4G3_HUMAN	EIF4G3	physical	28514442
COG5_HUMAN	COG5	physical	28514442
SYRC_HUMAN	RARS	physical	28514442
IPO7_HUMAN	IPO7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.