SOSSC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOSSC_HUMAN
• UniProt AC: Q9NRY2
• Protein Name: SOSS complex subunit C
• Gene Name: INIP
• Organism: Homo sapiens (Human).
• Sequence Length: 104
• Subcellular Localization: Nucleus . Localizes to nuclear foci following DNA damage.
• Protein Description: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways..
• Protein Sequence: MAANSSGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASIALSRPSLNKDFRDHAEQQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAANSSGQG ------CCCCCCCCC	18.49	19413330
5	Phosphorylation	---MAANSSGQGFQN ---CCCCCCCCCCCC	30.99	22210691
6	Phosphorylation	--MAANSSGQGFQNK --CCCCCCCCCCCCC	34.64	22210691
24	Acetylation	AILAELDKEKRKLLM EHHHCCHHHHHHHHH	77.18	26051181
28	Ubiquitination	ELDKEKRKLLMQNQS CCHHHHHHHHHCCCC	57.97	21890473
28 (in isoform 1)	Ubiquitination	-	57.97	21890473
35	Phosphorylation	KLLMQNQSSTNHPGA HHHHCCCCCCCCCCC	46.83	26074081
36	Phosphorylation	LLMQNQSSTNHPGAS HHHCCCCCCCCCCCC	24.38	26074081
37	Phosphorylation	LMQNQSSTNHPGASI HHCCCCCCCCCCCCH	42.67	26074081
43	Phosphorylation	STNHPGASIALSRPS CCCCCCCCHHCCCCC	17.82	26074081
47	Phosphorylation	PGASIALSRPSLNKD CCCCHHCCCCCCCHH	32.88	26074081
50	Phosphorylation	SIALSRPSLNKDFRD CHHCCCCCCCHHHHH	43.39	25159151
53	Ubiquitination	LSRPSLNKDFRDHAE CCCCCCCHHHHHHHH	64.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOSSC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOSSC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOSSC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOSB1_HUMAN	NABP2	physical	19683501
SOSB2_HUMAN	NABP1	physical	19683501
INT3_HUMAN	INTS3	physical	19683501
A4_HUMAN	APP	physical	21832049
TF3C6_HUMAN	GTF3C6	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330