TF3C6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF3C6_HUMAN
• UniProt AC: Q969F1
• Protein Name: General transcription factor 3C polypeptide 6
• Gene Name: GTF3C6
• Organism: Homo sapiens (Human).
• Sequence Length: 213
• Subcellular Localization: Nucleus .
• Protein Description: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters..
• Protein Sequence: MAAAADERSPEDGEDEEEEEQLVLVELSGIIDSDFLSKCENKCKVLGIDTERPILQVDSCVFAGEYEDTLGTCVIFEENVEHADTEGNNKTVLKYKCHTMKKLSMTRTLLTEKKEGEENIGGVEWLQIKDNDFSYRPNMICNFLHENEDEEVVASAPDKSLELEEEEIQMNDSSNLSCEQEKPMHLEIEDSGPLIDIPSETEGSVFMETQMLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAADERS ------CCCCCCCCC	13.05	21406692
9	Phosphorylation	AAAADERSPEDGEDE CCCCCCCCCCCCCCH	30.50	25849741
28	Phosphorylation	QLVLVELSGIIDSDF HEEEEEECCCCCHHH	17.91	21406692
59	Phosphorylation	RPILQVDSCVFAGEY CCEEEECEEEECCCC	17.21	24275569
104	Phosphorylation	CHTMKKLSMTRTLLT EEHHHHHHHEEEEHH	27.30	24719451
113	Acetylation	TRTLLTEKKEGEENI EEEEHHCCCCCCCCC	51.38	7363943
113	Sumoylation	TRTLLTEKKEGEENI EEEEHHCCCCCCCCC	51.38	-
113	Sumoylation	TRTLLTEKKEGEENI EEEEHHCCCCCCCCC	51.38	-
114	Ubiquitination	RTLLTEKKEGEENIG EEEHHCCCCCCCCCC	65.79	29967540
129	Ubiquitination	GVEWLQIKDNDFSYR CEEEEEECCCCCCCC	37.20	-
155	Phosphorylation	EDEEVVASAPDKSLE CCHHHEECCCCCCEE	28.82	26074081
160	Phosphorylation	VASAPDKSLELEEEE EECCCCCCEEECHHH	34.16	26074081
173	Phosphorylation	EEIQMNDSSNLSCEQ HHHCCCCCCCCCCCC	19.00	25159151
174	Phosphorylation	EIQMNDSSNLSCEQE HHCCCCCCCCCCCCC	44.66	25159151
177	Phosphorylation	MNDSSNLSCEQEKPM CCCCCCCCCCCCCCC	21.62	26074081
199	Phosphorylation	GPLIDIPSETEGSVF CCCCCCCCCCCCCEE	58.44	26074081
201	Phosphorylation	LIDIPSETEGSVFME CCCCCCCCCCCEEEE	50.40	26074081
204	Phosphorylation	IPSETEGSVFMETQM CCCCCCCCEEEEEEE	13.12	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF3C6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF3C6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF3C6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF3C5_HUMAN	GTF3C5	physical	17409385
TF3C4_HUMAN	GTF3C4	physical	17409385
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.