S11IP_HUMAN - dbPTM
S11IP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S11IP_HUMAN
UniProt AC Q8N1F8
Protein Name Serine/threonine-protein kinase 11-interacting protein
Gene Name STK11IP
Organism Homo sapiens (Human).
Sequence Length 1088
Subcellular Localization Cytoplasm . Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.
Protein Description May regulate STK11/LKB1 function by controlling its subcellular localization..
Protein Sequence MTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCGSDHVVLLAVSRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTRDHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLVVVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVLLPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFYLRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVRVREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWEELFSIGLRTVIQEALALDR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12UbiquitinationQRDSLLWKLAGLLRE
HHHHHHHHHHHHHHH		3.3133845483
23UbiquitinationLLRESGDVVLSGCST
HHHHHCCEEEECCCH		28.55-
103UbiquitinationPGPTGPIKIFPFKSL
CCCCCCEEEECCCCC		17.72-
103UbiquitinationPGPTGPIKIFPFKSL
CCCCCCEEEECCCCC		17.7221890473
108UbiquitinationPIKIFPFKSLRHLEL
CEEEECCCCCCCEEE		31.3323000965
114 (in isoform 1)Ubiquitination-41.2321890473
114UbiquitinationFKSLRHLELRGVPLH
CCCCCCEEECCCCHH		41.2321890473
120PhosphorylationLELRGVPLHCLHGLR
EEECCCCHHHHHHHH		30.8924719451
182PhosphorylationLTALDSSLRLLSALR
HHHHHHHHHHHHHHH		19.7922798277
273PhosphorylationLEGHRELSPLWLLAE
HCCCHHCCHHHHHHH		7.28-
283UbiquitinationWLLAELRKLYLEGNP
HHHHHHHHHHHCCCC		6.87-
283UbiquitinationWLLAELRKLYLEGNP
HHHHHHHHHHHCCCC		6.8721890473
284PhosphorylationLLAELRKLYLEGNPL
HHHHHHHHHHCCCCC		17.13-
294 (in isoform 1)Ubiquitination-54.8521890473
294UbiquitinationEGNPLWFHPEHRAAT
CCCCCCCCHHHHHHH		54.8521890473
306PhosphorylationAATAQYLSPRARDAA
HHHHHHCCHHHHHHH		29.61-
317PhosphorylationRDAATGFLLDGKVLS
HHHHCCEEECCEEEE		13.86-
360PhosphorylationTSGGPDLSDSLSSGG
CCCCCCCHHHHHCCC		40.81-
371PhosphorylationSSGGVVTQPLLHKVK
HCCCCCCHHHHHHHH		32.3124275569
387PhosphorylationRVRVRRASISEPSDT
CCEEEECCCCCCCCC		51.8619664995
389PhosphorylationRVRRASISEPSDTDP
EEEECCCCCCCCCCC		37.0319413330
392PhosphorylationRASISEPSDTDPEPR
ECCCCCCCCCCCCCC		9.5319651622
394PhosphorylationSISEPSDTDPEPRTL
CCCCCCCCCCCCCCC		4.4319413330
398PhosphorylationPSDTDPEPRTLNPSP
CCCCCCCCCCCCCCC		25.4929255136
400PhosphorylationDTDPEPRTLNPSPAG
CCCCCCCCCCCCCCC		40.7423927012
403PhosphorylationPEPRTLNPSPAGWFV
CCCCCCCCCCCCCHH		49.4429255136
404PhosphorylationEPRTLNPSPAGWFVQ
CCCCCCCCCCCCHHH		66.8827251275
405PhosphorylationPRTLNPSPAGWFVQQ
CCCCCCCCCCCHHHC		58.7627273156
411PhosphorylationSPAGWFVQQHPELEL
CCCCCHHHCCHHHHH		41.4228450419
415PhosphorylationWFVQQHPELELMSSF
CHHHCCHHHHHHHHH		26.7222617229
421PhosphorylationPELELMSSFRERFGR
HHHHHHHHHHHHHCC		4.2827251275
431PhosphorylationERFGRNWLQYRSHLE
HHHCCCHHHHHHCCC		38.6626657352
432PhosphorylationRFGRNWLQYRSHLEP
HHCCCHHHHHHCCCC		17.8526657352
446PhosphorylationPSGNPLPATPTTSAP
CCCCCCCCCCCCCCC		27.7325850435
451PhosphorylationLPATPTTSAPSAPPA
CCCCCCCCCCCCCCC		41.6525850435
454PhosphorylationTPTTSAPSAPPASSQ
CCCCCCCCCCCCHHC		43.15-
458PhosphorylationSAPSAPPASSQGPDT
CCCCCCCCHHCCCCC		21.1625850435
460PhosphorylationPSAPPASSQGPDTAP
CCCCCCHHCCCCCCC		29.0928464451
461PhosphorylationSAPPASSQGPDTAPR
CCCCCHHCCCCCCCC		24.8925850435
462PhosphorylationAPPASSQGPDTAPRP
CCCCHHCCCCCCCCC		40.4330206219
465PhosphorylationASSQGPDTAPRPSPP
CHHCCCCCCCCCCCC		53.8029255136
470PhosphorylationPDTAPRPSPPQEEAR
CCCCCCCCCCHHHHC		29.0323401153
471PhosphorylationDTAPRPSPPQEEARG
CCCCCCCCCHHHHCC		41.0629255136
476PhosphorylationPSPPQEEARGPQESP
CCCCHHHHCCCCCCC		41.5129255136
481PhosphorylationEEARGPQESPQKMSE
HHHCCCCCCCHHHCH		50.9529255136
482PhosphorylationEARGPQESPQKMSEE
HHCCCCCCCHHHCHH		36.9627251275
493PhosphorylationMSEEVRAEPQEEEEE
HCHHHHCCCHHHHHH		27.6428176443
498PhosphorylationRAEPQEEEEEKEGKE
HCCCHHHHHHHHCHH		37.3326074081
562PhosphorylationRECFLRVTSAHLFEV
CCCEEEECCHHHHHH		19.9727251275
573PhosphorylationLFEVELQAARTLERL
HHHHHHHHHHHHHHH		17.4828450419
574PhosphorylationFEVELQAARTLERLE
HHHHHHHHHHHHHHH		15.7228450419
584PhosphorylationLERLELQSLEAAEIE
HHHHHHHHHHHHCCC		16.13-
595PhosphorylationAEIEPEAQAQRSPRP
HCCCHHHHHHCCCCC		40.5826330541
599PhosphorylationPEAQAQRSPRPTGSD
HHHHHHCCCCCCCCC		14.6623186163
605PhosphorylationRSPRPTGSDLLPGAP
CCCCCCCCCCCCCCC		22.2619651622
610PhosphorylationTGSDLLPGAPILSLR
CCCCCCCCCCEEEEE		17.1230266825
614PhosphorylationLLPGAPILSLRFSYI
CCCCCCEEEEEEEEE		51.0730278072
616PhosphorylationPGAPILSLRFSYICP
CCCCEEEEEEEEECC		27.8030278072
626PhosphorylationSYICPDRQLRRYLVL
EEECCCHHHHHEECC		20.4427251275
631PhosphorylationDRQLRRYLVLEPDAH
CHHHHHEECCCCCHH		12.11-
663PhosphorylationREQLGEARDLLLGRF
HHHHHHHHHHHHHHH		25.77-
690PhosphorylationEPRMGLDSEEGWRPL
CCCCCCCCCCCCHHH		15.42-
701PhosphorylationWRPLFQKTESPAVCP
CHHHHCCCCCCCCCC		42.4622617229
712PhosphorylationAVCPNCGSDHVVLLA
CCCCCCCCCCEEEEE		30.8023312004
714PhosphorylationCPNCGSDHVVLLAVS
CCCCCCCCEEEEEEE		24.3228348404
721PhosphorylationHVVLLAVSRGTPNRE
CEEEEEEECCCCCHH		3.1327251275
723PhosphorylationVLLAVSRGTPNRERK
EEEEEECCCCCHHHH		27.0927251275
732PhosphorylationPNRERKQGEQSLAPS
CCHHHHCCCCCCCCC		21.2725159151
735PhosphorylationERKQGEQSLAPSPSA
HHHCCCCCCCCCCCC		19.1125159151
739PhosphorylationGEQSLAPSPSASPVC
CCCCCCCCCCCCCCC		71.5127251275
741PhosphorylationQSLAPSPSASPVCHP
CCCCCCCCCCCCCCC		58.8827251275
746PhosphorylationSPSASPVCHPPGHGD
CCCCCCCCCCCCCCC		23.3827732954
750PhosphorylationSPVCHPPGHGDHLDR
CCCCCCCCCCCHHHH		26.3630108239
752PhosphorylationVCHPPGHGDHLDRAK
CCCCCCCCCHHHHHH		45.7927732954
754PhosphorylationHPPGHGDHLDRAKNS
CCCCCCCHHHHHHCC		23.3930108239
761PhosphorylationHLDRAKNSPPQAPST
HHHHHHCCCCCCCCC		41.6919664995
772PhosphorylationAPSTRDHGSWSLSPP
CCCCCCCCCCCCCCC		36.9329255136
773PhosphorylationPSTRDHGSWSLSPPP
CCCCCCCCCCCCCCH		34.1223186163
775PhosphorylationTRDHGSWSLSPPPER
CCCCCCCCCCCCHHH		70.1027251275
777PhosphorylationDHGSWSLSPPPERCG
CCCCCCCCCCHHHCC		30.8723186163
778PhosphorylationHGSWSLSPPPERCGL
CCCCCCCCCHHHCCC		38.8123403867
779PhosphorylationGSWSLSPPPERCGLR
CCCCCCCCHHHCCCC		38.7723403867
784PhosphorylationSPPPERCGLRSVDHR
CCCHHHCCCCCCCHH		15.2928355574
786PhosphorylationPPERCGLRSVDHRLR
CHHHCCCCCCCHHHH		22.2223401153
788PhosphorylationERCGLRSVDHRLRLF
HHCCCCCCCHHHHHH		29.8228355574
1002PhosphorylationASEKVPPSGPGPAVR
CCCCCCCCCCCCCCE		24.68-
1013PhosphorylationPAVRVREQQPLSSLS
CCCEEEECCCCCCCH		52.1024667141
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S11IP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S11IP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S11IP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STK11_HUMANSTK11physical
11741830
SMAD4_HUMANSMAD4physical
11741830
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S11IP_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, AND MASSSPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398; SER-400 ANDTHR-405, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398; SER-400; SER-403AND SER-772, AND MASS SPECTROMETRY.

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